Literature DB >> 21534930

Interactions between proteins and platinum-containing anti-cancer drugs.

Cristina Bischin1, Alexandru Lupan, Vicentiu Taciuc, Radu Silaghi-Dumitrescu.   

Abstract

Cisplatin and its congeners are well-known to exert their therapeutic effects on cancer via interaction with DNA in the cell nucleus. On the other hand, the undesirable side-effects of these drugs appear to also be linked, at least to some extent, to interaction of the platinum with proteins and peptides. For other classes of anticancer drugs, interaction with proteins is in fact the primary pathway whereby therapeutically-useful effects are achieved. Here, a review is given of the known instances of interaction of cisplatin and related compounds with proteins and biologically relevant peptides, with emphasis on structural and reactivity aspects.

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Year:  2011        PMID： 21534930     DOI： 10.2174/138955711795049844

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  7 in total

Review 1.  Killing of cancer cells through the use of eukaryotic expression vectors harbouring genes encoding nucleases and ribonuclease inhibitor.

Authors:  Elena M Glinka
Journal:  Tumour Biol       Date:  2015-04-01

2.  Developing multisite empirical force field models for Pt(II) and cisplatin.

Authors:  John P Cvitkovic; George A Kaminski
Journal:  J Comput Chem       Date:  2016-11-11       Impact factor: 3.376

3.  Insights into the structure-activity relationships of chiral 1,2-diaminophenylalkane platinum(II) anticancer derivatives.

Authors:  Gilles Berger; Luca Fusaro; Michel Luhmer; Joanna Czapla-Masztafiak; Ewelina Lipiec; Jakub Szlachetko; Yves Kayser; Daniel L A Fernandes; Jacinto Sá; François Dufrasne; Sophie Bombard
Journal:  J Biol Inorg Chem       Date:  2015-05-16       Impact factor: 3.358

4.  Metabolism of cisplatin in the organs of Rattus norvegicus: role of Glutathione S-transferase P1.

Authors:  Ritika Nagar; Amir Riyaz Khan; Anuj Poonia; Pankaj Kishor Mishra; Simendra Singh
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2014-01-29       Impact factor: 2.441

5.  Mono and dinuclear platinum and palladium complexes containing adamantane-azole ligands: DNA and BSA interaction and cytotoxicity.

Authors:  Ana Luiza de Andrade Querino; Jessika Thayanne da Silva; Josiane Teixeira Silva; Gustavo Miguel Alvarenga; Carolina Hahn da Silveira; Mariana Torquato Quezado de Magalhães; Otávio Augusto Chaves; Bernardo Almeida Iglesias; Renata Diniz; Heveline Silva
Journal:  J Biol Inorg Chem       Date:  2019-10-16       Impact factor: 3.358

6.  The binding assessment with human serum albumin of novel six-coordinate Pt(IV) complexes, containing bidentate nitrogen donor/methyl ligands.

Authors:  Reza Yousefi; Asghar Taheri-Kafrani; Sayed Masoud Nabavizadeh; Zahra Pouryasin; Mohammad Bagher Shahsavani; Kazem Khoshaman; Mehdi Rashidi
Journal:  Mol Biol Res Commun       Date:  2015-12

7.  Polyphosphate Functions In Vivo as an Iron Chelator and Fenton Reaction Inhibitor.

Authors:  François Beaufay; Ellen Quarles; Allison Franz; Olivia Katamanin; Wei-Yun Wholey; Ursula Jakob
Journal:  mBio       Date:  2020-07-28       Impact factor: 7.867
  7 in total

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