Literature DB >> 21533445

Cytolytic and tumor inhibitory antibodies against UK114 protein in the sera of cancer patients.

G Bussolati1, M Geuna, B Bussolati, M Millesimo, M Botta, A Bartorelli.   

Abstract

UK114 is a 14 kDa protein identified in the perchloric acid soluble extract of goat liver. Anti-UK114 antibodies identify this protein as expressed by the membrane of human cancer cells. In the present study, anti-UK114 antibodies were detected in the sera of cancer patients by ELISA and by immunofluorescence tests using human cancer cell lines as a target. UK114 protein is antigenic in cancer patients. Human anti-UK114 antibodies have cytolytic effects in vitro and their presence correlates with inhibition of growth of human carcinoma cells xenografted in nu/nu mice. This finding may open new prospects for immunotherapy.

Entities:  

Year:  1997        PMID： 21533445     DOI： 10.3892/ijo.10.4.779

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  6 in total

1.  Identification of a perchloric acid-soluble protein (PSP)-like ribonuclease from Trichomonas vaginalis.

Authors:  Alma Villalobos-Osnaya; Georgina Garza-Ramos; Iris N Serratos; César Millán-Pacheco; Arturo González-Robles; Rossana Arroyo; Laura Itzel Quintas-Granados; María Elizbeth Alvarez-Sanchez
Journal:  Parasitol Res       Date:  2018-09-06       Impact factor: 2.289

Review 2.  From microbiology to cancer biology: the Rid protein family prevents cellular damage caused by endogenously generated reactive nitrogen species.

Authors:  Diana M Downs; Dustin C Ernst
Journal:  Mol Microbiol       Date:  2015-02-26       Impact factor: 3.501

3.  Using D- and L-Amino Acid Oxidases to Generate the Imino Acid Substrate to Measure the Activity of the Novel Rid (Enamine/Imine Deaminase) Class of Enzymes.

Authors:  Stefania Digiovanni; Genny Degani; Laura Popolo; Maria Antonietta Vanoni
Journal:  Methods Mol Biol       Date:  2021

4.  Imine Deaminase Activity and Conformational Stability of UK114, the Mammalian Member of the Rid Protein Family Active in Amino Acid Metabolism.

Authors:  Genny Degani; Alberto Barbiroli; Luca Regazzoni; Laura Popolo; Maria Antonietta Vanoni
Journal:  Int J Mol Sci       Date:  2018-03-22       Impact factor: 5.923

5.  Members of the Rid protein family have broad imine deaminase activity and can accelerate the Pseudomonas aeruginosa D-arginine dehydrogenase (DauA) reaction in vitro.

Authors:  Kelsey M Hodge-Hanson; Diana M Downs
Journal:  PLoS One       Date:  2017-09-28       Impact factor: 3.240

6.  Mmf1p Couples Amino Acid Metabolism to Mitochondrial DNA Maintenance in Saccharomyces cerevisiae.

Authors:  Dustin C Ernst; Diana M Downs
Journal:  mBio       Date:  2018-02-27       Impact factor: 7.867
  6 in total

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