OBJECTIVES: To determine age and gender specific reference intervals for bone markers. DESIGN AND METHODS: Morning blood samples were collected after overnight fast from 356 healthy children (6 to 18 year-old) for the determination of bone marker levels, PTH and vitamin D(3). Multiple regression analysis was done to assess the effect of factors that could influence the bone marker levels; the central 95% reference interval and their 90% CI were calculated. RESULTS: After excluding samples when BMI-z -scores were <-2 or >+2, both vitamin D(3) and PTH levels were abnormal and from children who used steroids the remainder were partitioned using Tanner stage based chronological age. As expected the reference intervals show a significant variation with age and gender. All the bone marker levels, except total alkaline phosphatase, were significantly higher in puberty with vitamin D(3) >75nmol/L. CONCLUSION: Vitamin D status, age and gender are important for establishing reference intervals of bone markers in healthy children.
OBJECTIVES: To determine age and gender specific reference intervals for bone markers. DESIGN AND METHODS: Morning blood samples were collected after overnight fast from 356 healthy children (6 to 18 year-old) for the determination of bone marker levels, PTH and vitamin D(3). Multiple regression analysis was done to assess the effect of factors that could influence the bone marker levels; the central 95% reference interval and their 90% CI were calculated. RESULTS: After excluding samples when BMI-z -scores were <-2 or >+2, both vitamin D(3) and PTH levels were abnormal and from children who used steroids the remainder were partitioned using Tanner stage based chronological age. As expected the reference intervals show a significant variation with age and gender. All the bone marker levels, except total alkaline phosphatase, were significantly higher in puberty with vitamin D(3) >75nmol/L. CONCLUSION:Vitamin D status, age and gender are important for establishing reference intervals of bone markers in healthy children.
Authors: Julie J Kim-Chang; Lorena Wilson; Cliburn Chan; Bernard Fischer; Guglielmo Venturi; Maureen M Goodenow; Grace Aldrovandi; Thomas J Weber; John W Sleasman Journal: AIDS Res Hum Retroviruses Date: 2019-06-27 Impact factor: 2.205
Authors: Samuel D Vasikaran; Sa Paul Chubb; Peter R Ebeling; Nicole Jenkins; Graham Rd Jones; Mark A Kotowicz; Howard A Morris; Hans-Gerhard Schneider; Markus J Seibel; Greg Ward Journal: Clin Biochem Rev Date: 2014-11