| Literature DB >> 215227 |
A Wiseman, T K Lim, L F Woods.
Abstract
The drug metabolising enzyme cytochrome P-450 has been studied in great detail in mammalian systems and its presence in microorganisms is also well established. However, neither its function nor its means of control in brewer's yeast, Saccharomyces cerevisiae, has been investigated. We demonstrate here using yeast protoplasts that it is the intracellular concentration of cyclic AMP which controls, by repression, the de novo synthesis of the enzyme, and also that cyclic AMP concentrations are in turn inversely related to the concentration of glucose in the yeast growth medium.Entities:
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Year: 1978 PMID： 215227 DOI： 10.1016/0304-4165(78)90335-5
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002