Literature DB >> 1846852

Induction and substrate specificity of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae Y222.

G D Wright1, J F Honek.   

Abstract

The potential inducibility of the lanosterol 14 alpha-demethylase (P-45014DM) from Saccharomyces cerevisiae Y222 by xenobiotics was investigated. This enzyme and NADPH-cytochrome P-450 reductase were unaffected by a number of compounds known to induce mammalian and some yeast cytochrome P-450 monooxygenases. Furthermore, dibutyryl cyclic AMP did not affect P-45014DM or P-450 reductase levels, while growth at 37 degrees C resulted in a slight decrease. P-45014DM was found to be specific for lanosterol and did not metabolize a number of P-450 substrates including benzo[a]pyrene.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1846852      PMCID： PMC207222          DOI： 10.1128/jb.173.3.1035-1040.1991

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  43 in total

1.  Relationship of cytochrome P-450 to growth phase of brewer's yeast in 1 per cent- or 20 per cent-glucose medium.

Authors:  A Wiseman; T K Lim; C McCloud
Journal:  Biochem Soc Trans       Date:  1975       Impact factor: 5.407

2.  Induction of cytochrome P450 in petroleum-assimilating yeast-II. Comparison of protein synthesizing activity in the cells grown on glucose and n-tetradecane.

Authors:  M Takagi; K Moriya; K Yano
Journal:  Cell Mol Biol Incl Cyto Enzymol       Date:  1979

3.  Regulation of the biosynthesis of cytochrome P-450 in brewer's yeast. Role of cyclic AMP.

Authors:  A Wiseman; T K Lim; L F Woods
Journal:  Biochim Biophys Acta       Date:  1978-12-18

4.  Involvement of cytochrome P-450 and a cyanide-sensitive enzyme in different steps of lanosterol demethylation by yeast microsomes.

Authors:  M Ohba; R Sato; Y Yoshida; T Nishino; H Katsuki
Journal:  Biochem Biophys Res Commun       Date:  1978-11-14       Impact factor: 3.575

5.  Cytochrome P-450 and the activation of promutagens in Saccharomyces cerevisiae.

Authors:  D F Callen; R M Philpot
Journal:  Mutat Res       Date:  1977-12       Impact factor: 2.433

6.  Assay of formaldehyde generated during microsomal oxidation reactions.

Authors:  J Werringloer
Journal:  Methods Enzymol       Date:  1978       Impact factor: 1.600

7.  Studies on the microsomal electron-transport system of anaerobically grown yeast. V. Purification and characterization of NADPH-cytochrome c reductase.

Authors:  S Kubota; Y Yoshida; H Kumaoka; A Furumichi
Journal:  J Biochem       Date:  1977-01       Impact factor: 3.387

8.  Effects of iron binding agents on Saccharomyces cerevisiae growth and cytochrome P450 content.

Authors:  G D Wright; J F Honek
Journal:  Can J Microbiol       Date:  1989-10       Impact factor: 2.419

9.  Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

Authors:  B J Song; H V Gelboin; S S Park; C S Yang; F J Gonzalez
Journal:  J Biol Chem       Date:  1986-12-15       Impact factor: 5.157

10.  Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. I. Purification and spectral properties.

Authors:  Y Yoshida; Y Aoyama
Journal:  J Biol Chem       Date:  1984-02-10       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.