BACKGROUND: Self-report scales are used to assess medication adherence. Data on how to discriminate change in self-reported adherence over time from random variability are limited. OBJECTIVE: To determine the minimal detectable change for scores on the 8-item Morisky Medication Adherence Scale (MMAS-8). METHODS: The MMAS-8 was administered twice, using a standard telephone script, with administration separated by 14-22 days, to 210 participants taking antihypertensive medication in the CoSMO (Cohort Study of Medication Adherence among Older Adults). MMAS-8 scores were calculated and participants were grouped into previously defined categories (<6, 6 to <8, and 8 for low, medium, and high adherence). RESULTS: The mean (SD) age of participants was 78.1 (5.8) years, 43.8% were black, and 68.1% were women. Overall, 8.1% (17/210), 16.2% (34/210), and 51.0% (107/210) of participants had low, medium, and high MMAS-8 scores, respectively, at both survey administrations (overall agreement 75.2%; 158/210). The weighted κ statistic was 0.63 (95% CI 0.53 to 0.72). The intraclass correlation coefficient was 0.78. The within-person standard error of the mean for change in MMAS-8 scores was 0.81, which equated to a minimal detectable change of 1.98 points. Only 4.3% (9/210) of the participants had a change in MMAS-8 of 2 or more points between survey administrations. CONCLUSIONS: Within-person changes in MMAS-8 scores of 2 or more points over time may represent a real change in antihypertensive medication adherence.
BACKGROUND: Self-report scales are used to assess medication adherence. Data on how to discriminate change in self-reported adherence over time from random variability are limited. OBJECTIVE: To determine the minimal detectable change for scores on the 8-item Morisky Medication Adherence Scale (MMAS-8). METHODS: The MMAS-8 was administered twice, using a standard telephone script, with administration separated by 14-22 days, to 210 participants taking antihypertensive medication in the CoSMO (Cohort Study of Medication Adherence among Older Adults). MMAS-8 scores were calculated and participants were grouped into previously defined categories (<6, 6 to <8, and 8 for low, medium, and high adherence). RESULTS: The mean (SD) age of participants was 78.1 (5.8) years, 43.8% were black, and 68.1% were women. Overall, 8.1% (17/210), 16.2% (34/210), and 51.0% (107/210) of participants had low, medium, and high MMAS-8 scores, respectively, at both survey administrations (overall agreement 75.2%; 158/210). The weighted κ statistic was 0.63 (95% CI 0.53 to 0.72). The intraclass correlation coefficient was 0.78. The within-person standard error of the mean for change in MMAS-8 scores was 0.81, which equated to a minimal detectable change of 1.98 points. Only 4.3% (9/210) of the participants had a change in MMAS-8 of 2 or more points between survey administrations. CONCLUSIONS: Within-person changes in MMAS-8 scores of 2 or more points over time may represent a real change in antihypertensive medication adherence.
Authors: Marie Krousel-Wood; Cara Joyce; Elizabeth Holt; Paul Muntner; Larry S Webber; Donald E Morisky; Edward D Frohlich; Richard N Re Journal: Hypertension Date: 2011-10-03 Impact factor: 10.190
Authors: Catherine G Derington; Tyler H Gums; Adam P Bress; Jennifer S Herrick; Tom H Greene; Andrew E Moran; William S Weintraub; Ian M Kronish; Donald E Morisky; Katy E Trinkley; Joseph J Saseen; Kristi Reynolds; Jeffrey T Bates; Dan R Berlowitz; Tara I Chang; Michel Chonchol; William C Cushman; Capri G Foy; Charles T Herring; Lois Anne Katz; Marie Krousel-Wood; Nicholas M Pajewski; Leonardo Tamariz; Jordan B King Journal: Hypertension Date: 2019-07-01 Impact factor: 10.190
Authors: Dan R Berlowitz; Capri G Foy; Lewis E Kazis; Linda P Bolin; Molly B Conroy; Peter Fitzpatrick; Tanya R Gure; Paul L Kimmel; Kent Kirchner; Donald E Morisky; Jill Newman; Christine Olney; Suzanne Oparil; Nicholas M Pajewski; James Powell; Thomas Ramsey; Debra L Simmons; Joni Snyder; Mark A Supiano; Daniel E Weiner; Jeff Whittle Journal: N Engl J Med Date: 2017-08-24 Impact factor: 91.245
Authors: Suliman A AlGhurair; Christine A Hughes; Scot H Simpson; Lisa M Guirguis Journal: J Clin Hypertens (Greenwich) Date: 2012-08-20 Impact factor: 3.738