Literature DB >> 21518842

In vitro and in vivo activities of E-101 solution against Acinetobacter baumannii isolates from U.S. military personnel.

G A Denys1, J C Davis, P D O'Hanley, J T Stephens.   

Abstract

We evaluated the in vitro and in vivo activity of a novel topical myeloperoxidase-mediated antimicrobial, E-101 solution, against 5 multidrug-resistant Acinetobacter baumannii isolates recovered from wounded American soldiers. Time-kill studies demonstrated rapid bactericidal activity against all A. baumannii strains tested in the presence of 3% blood. The in vitro bactericidal activity of E-101 solution against A. baumannii strains was confirmed in a full-thickness excision rat model. Additional in vivo studies appear warranted.

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Year:  2011        PMID： 21518842      PMCID： PMC3122402          DOI： 10.1128/AAC.01606-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Enhanced killing of myeloperoxidase-coated bacteria in the myeloperoxidase-H2O2-Cl- system.

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Journal:  J Infect Dis       Date:  1978-04       Impact factor: 5.226

Review 2.  Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.

Authors:  M B Hampton; A J Kettle; C C Winterbourn
Journal:  Blood       Date:  1998-11-01       Impact factor: 22.113

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Journal:  Prog Clin Biol Res       Date:  1984

4.  Time resolved studies of 1.27 micron luminescence from singlet oxygen generated in homogeneous and microheterogeneous fluids.

Authors:  M A Rodgers
Journal:  Photochem Photobiol       Date:  1983-01       Impact factor: 3.421

5.  Infected surface wound: an experimental model and a method for the quantitation of bacteria in infected tissues.

Authors:  D G Saymen; P Nathan; I A Holder; E O Hill; B G Macmillan
Journal:  Appl Microbiol       Date:  1972-03

6.  Binding of myeloperoxidase to bacteria: effect on hydroxyl radical formation and susceptibility to oxidant-mediated killing.

Authors:  B E Britigan; H R Ratcliffe; G R Buettner; G M Rosen
Journal:  Biochim Biophys Acta       Date:  1996-08-13

7.  Role of high-avidity binding of human neutrophil myeloperoxidase in the killing of Actinobacillus actinomycetemcomitans.

Authors:  K T Miyasaki; J J Zambon; C A Jones; M E Wilson
Journal:  Infect Immun       Date:  1987-05       Impact factor: 3.441

8.  Reduced-oxidized difference spectral analysis and chemiluminescence-based Scatchard analysis demonstrate selective binding of myeloperoxidase to microbes.

Authors:  Robert C Allen; Jackson T Stephens
Journal:  Luminescence       Date:  2010-03-30       Impact factor: 2.464

9.  Binding and inhibition of myeloperoxidase (MPO): a major function of ceruloplasmin?

Authors:  M Segelmark; B Persson; T Hellmark; J Wieslander
Journal:  Clin Exp Immunol       Date:  1997-04       Impact factor: 4.330

Review 10.  Biological reactivity and biomarkers of the neutrophil oxidant, hypochlorous acid.

Authors:  Christine C Winterbourn
Journal:  Toxicology       Date:  2002-12-27       Impact factor: 4.221
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  2 in total

1.  Five-year longitudinal assessment (2008 to 2012) of E-101 solution activity against clinical target and antimicrobial-resistant pathogens.

Authors:  Gerald A Denys; Chris M Pillar; Daniel F Sahm; Peter O'Hanley; Jackson T Stephens
Journal:  Antimicrob Agents Chemother       Date:  2014-05-19       Impact factor: 5.191

2.  Mechanism of Microbicidal Action of E-101 Solution, a Myeloperoxidase-Mediated Antimicrobial, and Its Oxidative Products.

Authors:  Gerald A Denys; Neil C Devoe; Polyxeni Gudis; Meghan May; Robert C Allen; Jackson T Stephens
Journal:  Infect Immun       Date:  2019-06-20       Impact factor: 3.441
  2 in total

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