Literature DB >> 215119

The adenylate cyclase-activating activity of cholera toxin is not associated with a nicotinamide--adenine dinucleotide glycohydrolase activity.

R M Tait, S van Heyningen.   

Abstract

The NAD+ glycohydrolase activity of cholera-toxin samples can be separated from their adenylate cyclase-activating activity by polyacrylamide-gel electrophoresis and is inhibited by sodium dodecyl sulphate (which does not inhibit the action of toxin on cells), but not by antibodies to pure toxin. It is therefore probably not a true property of the toxin.

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Year:  1978        PMID： 215119      PMCID： PMC1186012          DOI： 10.1042/bj1741059

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

1.  Tritosol: a new scintillation cocktail based on Triton X-100.

Authors:  U Fricke
Journal:  Anal Biochem       Date:  1975-02       Impact factor: 3.365

2.  DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors:  B J DAVIS
Journal:  Ann N Y Acad Sci       Date:  1964-12-28       Impact factor: 5.691

3.  Activation by cholera toxin of adenylate cyclase solubilized from rat liver.

Authors:  S Heyningen
Journal:  Biochem J       Date:  1976-09-01       Impact factor: 3.857

4.  The equilibrium constant and the reversibility of the reaction catalysed by nicotinamide-adenine dinucleotide kinase from pigeon liver.

Authors:  D K Apps; A C Nairn
Journal:  Biochem J       Date:  1977-10-01       Impact factor: 3.857

5.  Transfer of ADP-ribose from NAD to choleragen: a subunit acts as catalyst and acceptor protein.

Authors:  J B Trepel; D M Chuang; N H Neff
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

Review 6.  Cholera toxin.

Authors:  S van Heyningen
Journal:  Biol Rev Camb Philos Soc       Date:  1977-11

7.  Activity of covalently cross-linked cholera toxin with the adenylate cyclase of intact and lysed pigeon erythrocytes.

Authors:  S van Heyningen
Journal:  Biochem J       Date:  1977-12-15       Impact factor: 3.857

8.  Effect of gangliosides and substrate analogues on the hydrolysis of nicotinamide adenine dinucleotide by choleragen.

Authors:  J Moss; J C Osborne; P H Fishman; H B Brewer; M Vaughan; R O Brady
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205

9.  Mechanism of adenylate cyclase activation by cholera toxin: inhibition of GTP hydrolysis at the regulatory site.

Authors:  D Cassel; Z Selinger
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

10.  Hydrolysis of nicotinamide adenine dinucleotide by choleragen and its A protomer: possible role in the activation of adenylate cyclase.

Authors:  J Moss; V C Manganiello; M Vaughan
Journal:  Proc Natl Acad Sci U S A       Date:  1976-12       Impact factor: 11.205
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  1 in total

1.  Binding of NAD+ by cholera toxin.

Authors:  T S Galloway; S van Heyningen
Journal:  Biochem J       Date:  1987-05-15       Impact factor: 3.857
  1 in total

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