Literature DB >> 21509317

A Case of Amiodarone-Induced Thyrotoxicosis: A diagnostic and therapeutic dilemma.

Ps Sudheer Ahamed1, Abe Mathew.   

Abstract

Amiodarone is an iodine rich agent widely used for the treatment of ventricular arrhythmias, paroxysmal supraventricular tachycardia, atrial fibrillation and flutter. However 14-18% of patients treated with amiodarone develop overt thyroid dysfunction in the form of either amiodarone-induced thyrotoxicosis (AIT) or amiodaroneinduced hypothyroidism (AIH). Two different types of AIT have been recognised and designated as Type 1 and Type 2. Distinguishing between the two is often difficult, but necessary for instituting appropriate treatment. We report a case of a 56 year-old male patient who was started on amiodarone for atrial fibrillation and then developed AIT. The challenges in the diagnosis and management of these patients are discussed.

Entities:  

Keywords:  Amiodarone; Apathetic hyperthyroidism; Arrhythmias; Case Report; Thyroid; Thyrotoxicosis

Year:  2009        PMID: 21509317      PMCID: PMC3074791     

Source DB:  PubMed          Journal:  Sultan Qaboos Univ Med J        ISSN: 2075-051X


  12 in total

Review 1.  The effects of amiodarone on the thyroid.

Authors:  E Martino; L Bartalena; F Bogazzi; L E Braverman
Journal:  Endocr Rev       Date:  2001-04       Impact factor: 19.871

Review 2.  Amiodarone-induced thyrotoxicosis.

Authors:  G H Daniels
Journal:  J Clin Endocrinol Metab       Date:  2001-01       Impact factor: 5.958

Review 3.  Perchlorate and the thyroid gland.

Authors:  J Wolff
Journal:  Pharmacol Rev       Date:  1998-03       Impact factor: 25.468

4.  Radioactive iodine thyroid uptake in patients with amiodarone-iodine-induced thyroid dysfunction.

Authors:  E Martino; L Bartalena; S Mariotti; F Aghini-Lombardi; C Ceccarelli; F Lippi; M Piga; A Loviselli; L Braverman; M Safran
Journal:  Acta Endocrinol (Copenh)       Date:  1988-10

5.  Amiodarone-induced thyrotoxicosis: clinical course and predictors of outcome.

Authors:  David Conen; Ludovic Melly; Christoph Kaufmann; Stefan Bilz; Peter Ammann; Beat Schaer; Christian Sticherling; Beat Muller; Stefan Osswald
Journal:  J Am Coll Cardiol       Date:  2007-06-04       Impact factor: 24.094

6.  Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy.

Authors:  E Martino; M Safran; F Aghini-Lombardi; R Rajatanavin; M Lenziardi; M Fay; A Pacchiarotti; N Aronin; E Macchia; C Haffajee
Journal:  Ann Intern Med       Date:  1984-07       Impact factor: 25.391

7.  Serum interleukin-6 in amiodarone-induced thyrotoxicosis.

Authors:  L Bartalena; L Grasso; S Brogioni; F Aghini-Lombardi; L E Braverman; E Martino
Journal:  J Clin Endocrinol Metab       Date:  1994-02       Impact factor: 5.958

Review 8.  Amiodarone induced thyrotoxicosis: diagnostic and therapeutic strategies.

Authors:  Gustavo A Cardenas; José M Cabral; Camilo A Leslie
Journal:  Cleve Clin J Med       Date:  2003-07       Impact factor: 2.321

9.  Nongoitrous (type I) amiodarone-associated thyrotoxicosis: evidence of follicular disruption in vitro and in vivo.

Authors:  M D Brennan; D Z Erickson; J A Carney; R S Bahn
Journal:  Thyroid       Date:  1995-06       Impact factor: 6.568

Review 10.  Management of amiodarone-induced thyrotoxicosis.

Authors:  Chinnadorai Rajeswaran; Rhidian John Shelton; Stephen George Gilbey
Journal:  Swiss Med Wkly       Date:  2003-11-22       Impact factor: 2.193

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