Literature DB >> 21508970

Desmosomes: new perpetrators in tumour suppression.

Rachel L Dusek1, Laura D Attardi.   

Abstract

Adherens junctions, which are intercellular adhesive complexes that are crucial for maintaining epithelial homeostasis, are downregulated in many cancers to promote tumour progression. However, the role of desmosomes - adhesion complexes that are related to adherens junctions - in carcinogenesis has remained elusive. Recent studies using mouse genetic approaches have uncovered a role for desmosomes in tumour suppression, demonstrating that desmosome downregulation occurs before that of adherens junctions to drive tumour development and early invasion, suggesting a two-step model of adhesion dysfunction in cancer progression.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21508970      PMCID： PMC3799918          DOI： 10.1038/nrc3051

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  134 in total

1.  Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland.

Authors:  Michael A Davis; Albert B Reynolds
Journal:  Dev Cell       Date:  2006-01       Impact factor: 12.270

2.  Desmocollin 3 is required for pre-implantation development of the mouse embryo.

Authors:  Zhining Den; Xing Cheng; Maria Merched-Sauvage; Peter J Koch
Journal:  J Cell Sci       Date:  2006-01-17       Impact factor: 5.285

3.  Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer.

Authors:  Mirna Perez-Moreno; Weimin Song; H Amalia Pasolli; Scott E Williams; Elaine Fuchs
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-22       Impact factor: 11.205

4.  Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation.

Authors:  Rajyalakshmi Luthra; Tsung-Teh Wu; Madan G Luthra; Julie Izzo; Enrique Lopez-Alvarez; Li Zhang; Jaime Bailey; Jeffrey H Lee; Robert Bresalier; Asif Rashid; Stephen G Swisher; Jaffer A Ajani
Journal:  J Clin Oncol       Date:  2005-12-12       Impact factor: 44.544

5.  Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy.

Authors:  Eduardo Garcia-Gras; Raffaella Lombardi; Michael J Giocondo; James T Willerson; Michael D Schneider; Dirar S Khoury; Ali J Marian
Journal:  J Clin Invest       Date:  2006-07       Impact factor: 14.808

6.  Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin.

Authors:  Agnieszka Kobielak; Elaine Fuchs
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-01       Impact factor: 11.205

7.  Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules.

Authors:  Ilse Hofmann; Marialuisa Casella; Martina Schnölzer; Tanja Schlechter; Herbert Spring; Werner W Franke
Journal:  Mol Biol Cell       Date:  2006-01-11       Impact factor: 4.138

8.  Loss of desmocollin 3 in mice leads to epidermal blistering.

Authors:  Jiangli Chen; Zhining Den; Peter J Koch
Journal:  J Cell Sci       Date:  2008-08-05       Impact factor: 5.285

9.  Plakophilin3 downregulation leads to a decrease in cell adhesion and promotes metastasis.

Authors:  Samrat T Kundu; Prajakta Gosavi; Nileema Khapare; Rachana Patel; Amol S Hosing; Girish B Maru; Arvind Ingle; James A Decaprio; Sorab N Dalal
Journal:  Int J Cancer       Date:  2008-11-15       Impact factor: 7.396

10.  Loss of desmoglein 1 expression associated with worse prognosis in head and neck squamous cell carcinoma patients.

Authors:  Michelle P Wong; Maggie Cheang; Erika Yorida; Andrew Coldman; C Blake Gilks; David Huntsman; Ken Berean
Journal:  Pathology       Date:  2008-10       Impact factor: 5.306
View more
  80 in total

1.  Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium.

Authors:  Andrew J Ewald; Robert J Huebner; Hildur Palsdottir; Jessie K Lee; Melissa J Perez; Danielle M Jorgens; Andrew N Tauscher; Kevin J Cheung; Zena Werb; Manfred Auer
Journal:  J Cell Sci       Date:  2012-02-17       Impact factor: 5.285

2.  Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion.

Authors:  Kun Jiang; Carl R Rankin; Porfirio Nava; Ronen Sumagin; Ryuta Kamekura; Sean R Stowell; Mingli Feng; Charles A Parkos; Asma Nusrat
Journal:  J Biol Chem       Date:  2014-02-24       Impact factor: 5.157

Review 3.  Desmosomes: regulators of cellular signaling and adhesion in epidermal health and disease.

Authors:  Jodi L Johnson; Nicole A Najor; Kathleen J Green
Journal:  Cold Spring Harb Perspect Med       Date:  2014-11-03       Impact factor: 6.915

Review 4.  Loss of E-Cadherin-Dependent Cell-Cell Adhesion and the Development and Progression of Cancer.

Authors:  Heather C Bruner; Patrick W B Derksen
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-03-01       Impact factor: 10.005

Review 5.  Classical and desmosomal cadherins at a glance.

Authors:  Masataka Saito; Dana K Tucker; Drew Kohlhorst; Carien M Niessen; Andrew P Kowalczyk
Journal:  J Cell Sci       Date:  2012-06-01       Impact factor: 5.285

6.  Desmosome dynamics in migrating epithelial cells requires the actin cytoskeleton.

Authors:  Brett J Roberts; Anjeza Pashaj; Keith R Johnson; James K Wahl
Journal:  Exp Cell Res       Date:  2011-09-16       Impact factor: 3.905

7.  Holding Tight: Cell Junctions and Cancer Spread.

Authors:  Alexander J Knights; Alister P W Funnell; Merlin Crossley; Richard C M Pearson
Journal:  Trends Cancer Res       Date:  2012

8.  Desmoglein-2 is overexpressed in non-small cell lung cancer tissues and its knockdown suppresses NSCLC growth by regulation of p27 and CDK2.

Authors:  Feng Cai; Qingqing Zhu; Yingying Miao; Simei Shen; Xin Su; Yi Shi
Journal:  J Cancer Res Clin Oncol       Date:  2016-09-14       Impact factor: 4.553

9.  Desmoglein-1, differentiation, and disease.

Authors:  Christoph M Hammers; John R Stanley
Journal:  J Clin Invest       Date:  2013-03-25       Impact factor: 14.808

Review 10.  Structure, function, and regulation of desmosomes.

Authors:  Andrew P Kowalczyk; Kathleen J Green
Journal:  Prog Mol Biol Transl Sci       Date:  2013       Impact factor: 3.622
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.