Mark A Klebanoff1, Margaret Harper, Yinglei Lai, John Thorp, Yoram Sorokin, Michael W Varner, Ronald J Wapner, Steve N Caritis, Jay D Iams, Marshall W Carpenter, Alan M Peaceman, Brian M Mercer, Anthony Sciscione, Dwight J Rouse, Susan M Ramin, Garland D Anderson. 1. *For a list of other members of the NICHD MFMU, see the Appendix online at http://links.lww.com/AOG/A235. From the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland; The Research Institute at Nationwide Children's Hospital, Columbus, Ohio; the Departments of Obstetrics and Gynecology, at Wake Forest University Health Sciences, Winston-Salem, North Carolina; The George Washington University Biostatistics Center, Washington, DC; University of North Carolina, Chapel Hill, North Carolina; Wayne State University, Detroit, Michigan; University of Utah Health Sciences Center, Salt Lake City, Utah; Columbia University, New York, New York; University of Pittsburgh, Pittsburgh, Pennsylvania; The Ohio State University, Columbus, Ohio; Women and Infants Hospital, Brown University, Providence, Rhode Island; Northwestern University, Chicago, Illinois; Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio; Drexel University College of Medicine, Philadelphia, Pennsylvania; University of Alabama at Birmingham, Birmingham, Alabama; University of Texas at Houston, Houston, Texas; and University of Texas Medical Branch, Galveston, Texas.
Abstract
OBJECTIVE: To estimate the association between fish consumption and erythrocyte omega-3 long-chain polyunsaturated fatty acids and preterm birth in a high-risk cohort. METHODS: This was an ancillary study to a randomized trial of omega-3 supplementation to prevent preterm birth in women with at least one previous spontaneous preterm delivery. Dietary fish intake was assessed by questionnaire and erythrocyte fatty acids were measured at enrollment (16-21 completed weeks of gestation). The association between fish consumption and preterm delivery was modeled with linear and quadratic terms. RESULTS: The probability of preterm birth was 48.6% among women eating fish less than once a month and 35.9% among women eating fish more often (P<.001). The adjusted odds ratio for preterm birth among women reporting moderately frequent fish consumption (three servings per week) was 0.60 (95% confidence interval 0.38-0.95), with no further reduction in preterm birth among women who consumed more than three servings of fish per week. Erythrocyte omega-3 levels correlated weakly but significantly with frequency of fish intake (Spearman r=0.22, P<.001); women in the lowest quartile of erythrocyte omega-3 levels were more likely to report consuming less than one fish meal per month (40.3%) than were women in the highest three quartiles (26.3%, P<.001). CONCLUSION: Moderate fish intake (up to three meals per week) before 22 weeks of gestation was associated with a reduction in repeat preterm birth. More than moderate consumption did not confer additional benefit. These results support the recommendations of the U.S. Food and Drug Administration and the American Congress of Obstetricians and Gynecologists for fish consumption during pregnancy. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00135902.
OBJECTIVE: To estimate the association between fish consumption and erythrocyte omega-3 long-chain polyunsaturated fatty acids and preterm birth in a high-risk cohort. METHODS: This was an ancillary study to a randomized trial of omega-3 supplementation to prevent preterm birth in women with at least one previous spontaneous preterm delivery. Dietary fish intake was assessed by questionnaire and erythrocyte fatty acids were measured at enrollment (16-21 completed weeks of gestation). The association between fish consumption and preterm delivery was modeled with linear and quadratic terms. RESULTS: The probability of preterm birth was 48.6% among women eating fish less than once a month and 35.9% among women eating fish more often (P<.001). The adjusted odds ratio for preterm birth among women reporting moderately frequent fish consumption (three servings per week) was 0.60 (95% confidence interval 0.38-0.95), with no further reduction in preterm birth among women who consumed more than three servings of fish per week. Erythrocyte omega-3 levels correlated weakly but significantly with frequency of fish intake (Spearman r=0.22, P<.001); women in the lowest quartile of erythrocyte omega-3 levels were more likely to report consuming less than one fish meal per month (40.3%) than were women in the highest three quartiles (26.3%, P<.001). CONCLUSION: Moderate fish intake (up to three meals per week) before 22 weeks of gestation was associated with a reduction in repeat preterm birth. More than moderate consumption did not confer additional benefit. These results support the recommendations of the U.S. Food and Drug Administration and the American Congress of Obstetricians and Gynecologists for fish consumption during pregnancy. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00135902.
Authors: H Iso; K M Rexrode; M J Stampfer; J E Manson; G A Colditz; F E Speizer; C H Hennekens; W C Willett Journal: JAMA Date: 2001-01-17 Impact factor: 56.272
Authors: Emily Oken; Jenny S Radesky; Robert O Wright; David C Bellinger; Chitra J Amarasiriwardena; Ken P Kleinman; Howard Hu; Matthew W Gillman Journal: Am J Epidemiol Date: 2008-03-18 Impact factor: 4.897
Authors: Emily Oken; Ken P Kleinman; Sjurdur F Olsen; Janet W Rich-Edwards; Matthew W Gillman Journal: Am J Epidemiol Date: 2004-10-15 Impact factor: 4.897
Authors: April F Mohanty; Mary Lou Thompson; Thomas M Burbacher; David S Siscovick; Michelle A Williams; Daniel A Enquobahrie Journal: Paediatr Perinat Epidemiol Date: 2015-07-03 Impact factor: 3.980
Authors: April F Mohanty; David S Siscovick; Michelle A Williams; Mary Lou Thompson; Thomas M Burbacher; Daniel A Enquobahrie Journal: Public Health Nutr Date: 2015-12-02 Impact factor: 4.022
Authors: Renata H Benjamin; Laura E Mitchell; Mark A Canfield; Adrienne T Hoyt; Dejian Lai; Tunu A Ramadhani; Suzan L Carmichael; Amy P Case; D Kim Waller Journal: Public Health Nutr Date: 2018-10-17 Impact factor: 4.022
Authors: J M Thorp; C A Camargo; P L McGee; M Harper; M A Klebanoff; Y Sorokin; M W Varner; R J Wapner; S N Caritis; J D Iams; M W Carpenter; A M Peaceman; B M Mercer; A Sciscione; D J Rouse; S M Ramin; G B Anderson Journal: BJOG Date: 2012-10-19 Impact factor: 6.531
Authors: Linda Englund-Ögge; Anne Lise Brantsæter; Margareta Haugen; Verena Sengpiel; Ali Khatibi; Ronny Myhre; Solveig Myking; Helle Margrete Meltzer; Marian Kacerovsky; Roy M Nilsen; Bo Jacobsson Journal: Am J Clin Nutr Date: 2012-08-01 Impact factor: 7.045