CONTEXT AND OBJECTIVE: GH has positive cognitive effects when given to GH-IGF-I-deficient patients. GH and IGF-I exert both neuroprotective and regenerative effects on experimental stroke. We investigated whether the endogenous serum IGF-I (s-IGF-I) levels correlated with recovery of functional independence in patients who had suffered an ischemic stroke. SUBJECTS AND METHODS: The s-IGF-I levels were measured in 407 patients (260 males, 147 females) with mean age of 55 (range, 18-69) yr and 40 randomly selected matched controls who were previously included in the Sahlgrenska Academy Study on Ischemic Stroke. Serum samples were collected on two occasions: acutely at 1-10 d (median, 4 d) after stroke and 3 months after the stroke. Recovery after ischemic stroke was evaluated using the modified Rankin scale 3 and 24 months after the stroke, and the Scandinavian Stroke Scale was used for assessments during the acute stage and 3 months after the stroke. RESULTS: The s-IGF-I levels were higher in the acute stage than after 3 months and compared with the controls (P < 0.001 and P < 0.01, respectively), and the s-IGF-I levels were progressively lower in the elderly patients. The levels of s-IGF-I in the acute phase and after 3 months both positively correlated with improvement in the modified Rankin scale scores between 3 and 24 months (P = 0.001; r = 0.174, and P < 0.001; r = 0.24, respectively). CONCLUSION: A high s-IGF-I during the rehabilitation phase of stroke correlates to better recovery of long-term function.
CONTEXT AND OBJECTIVE: GH has positive cognitive effects when given to GH-IGF-I-deficientpatients. GH and IGF-I exert both neuroprotective and regenerative effects on experimental stroke. We investigated whether the endogenous serum IGF-I (s-IGF-I) levels correlated with recovery of functional independence in patients who had suffered an ischemic stroke. SUBJECTS AND METHODS: The s-IGF-I levels were measured in 407 patients (260 males, 147 females) with mean age of 55 (range, 18-69) yr and 40 randomly selected matched controls who were previously included in the Sahlgrenska Academy Study on Ischemic Stroke. Serum samples were collected on two occasions: acutely at 1-10 d (median, 4 d) after stroke and 3 months after the stroke. Recovery after ischemic stroke was evaluated using the modified Rankin scale 3 and 24 months after the stroke, and the Scandinavian Stroke Scale was used for assessments during the acute stage and 3 months after the stroke. RESULTS: The s-IGF-I levels were higher in the acute stage than after 3 months and compared with the controls (P < 0.001 and P < 0.01, respectively), and the s-IGF-I levels were progressively lower in the elderly patients. The levels of s-IGF-I in the acute phase and after 3 months both positively correlated with improvement in the modified Rankin scale scores between 3 and 24 months (P = 0.001; r = 0.174, and P < 0.001; r = 0.24, respectively). CONCLUSION: A high s-IGF-I during the rehabilitation phase of stroke correlates to better recovery of long-term function.
Authors: Elizabeth N Allred; Olaf Dammann; Raina N Fichorova; Stephen R Hooper; Scott J Hunter; Robert M Joseph; Karl Kuban; Alan Leviton; Thomas Michael O'Shea; Megan N Scott Journal: J Neuroimmune Pharmacol Date: 2017-04-12 Impact factor: 4.147
Authors: Alan Leviton; Elizabeth N Allred; Raina N Fichorova; T Michael O'Shea; Lynn A Fordham; Karl K C Kuban; Olaf Dammann Journal: Eur J Paediatr Neurol Date: 2018-01-31 Impact factor: 3.140
Authors: Deborah De Geyter; Ann De Smedt; Wendy Stoop; Jacques De Keyser; Ron Kooijman Journal: CNS Neurosci Ther Date: 2016-04-15 Impact factor: 5.243
Authors: Fabrisia Ambrosio; Michael L Boninger; Clifford E Brubaker; Anthony Delitto; William R Wagner; Richard K Shields; Steven L Wolf; Thomas A Rando Journal: J Rehabil Res Dev Date: 2013
Authors: Han Yan; Matthew Mitschelen; Peter Toth; Nicole M Ashpole; Julie A Farley; Erik L Hodges; Junie P Warrington; Song Han; Kar-Ming Fung; Anna Csiszar; Zoltan Ungvari; William E Sonntag Journal: J Gerontol A Biol Sci Med Sci Date: 2014-08-06 Impact factor: 6.053