| Literature DB >> 21507570 |
Dandan Zheng1, Yancai Wang, Dianrui Zhang, Zhaoping Liu, Cunxian Duan, Lejiao Jia, Feihu Wang, Yue Liu, Guangpu Liu, Leilei Hao, Qiang Zhang.
Abstract
The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method. MTT assay, observation of morphological changes and apoptotic body showed that silybin nanosuspension could significantly enhance the in vitro cytotoxicity against PC-3 cells compared to the silybin solution. Flow cytometric (FCM) analysis demonstrated that silybin nanosuspension induced G1 cycle arrest and apoptosis in PC-3 cells. Thereby, the overall results suggest that the silybin nanosuspension represents a potential source of medicine for the treatment of human prostate cancer. CrownEntities:
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Year: 2011 PMID： 21507570 DOI： 10.1016/j.canlet.2011.03.028
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679