Literature DB >> 21506697

Hemoglobin adducts in workers exposed to 1,6-hexamethylene diisocyanate.

Sheila L Flack1, Kenneth W Fent, Linda G T Gaines, Jennifer M Thomasen, Stephen G Whittaker, Louise M Ball, Leena A Nylander-French.   

Abstract

We investigated the utility of 1,6-hexamethylene diamine (HDA) hemoglobin adducts as biomarkers of exposure to 1,6-hexamethylene diisocyanate (HDI) monomer. Blood samples from 15 spray painters applying HDI-containing paint were analyzed for hemoglobin HDA (HDA-Hb) and N-acetyl-1,6-hexamethylene diamine (monoacetyl-HDA-Hb) by GC-MS. HDA-Hb was detected in the majority of workers (≤1.2-37 ng/g Hb), whereas monoacetyl-HDA-Hb was detected in one worker (0.06 ng/g Hb). The stronger, positive association between HDA-Hb and cumulative HDI exposure (r(2) = 0.3, p < 0.06) than same day exposure (p ≥ 0.13) indicates long-term elimination kinetics for HDA-Hb adducts. This association demonstrates the suitability of HDA-Hb adducts for further validation as a biomarker of HDI exposure.

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Year:  2011        PMID： 21506697      PMCID： PMC4174272          DOI： 10.3109/1354750X.2010.549242

Source DB:  PubMed          Journal:  Biomarkers        ISSN： 1354-750X            Impact factor:   2.658


  37 in total

1.  Determination of dichlorobenzidine-hemoglobin adducts by GC/MS-NCI.

Authors:  R Joppich-Kuhn; R Hänggi; P Sagelsdorff; A E Smith; H J Weideli; M Joppich
Journal:  Int Arch Occup Environ Health       Date:  1997       Impact factor: 3.015

2.  Dermal, inhalation, and internal exposure to 1,6-HDI and its oligomers in car body repair shop workers and industrial spray painters.

Authors:  A Pronk; F Yu; J Vlaanderen; E Tielemans; L Preller; I Bobeldijk; J A Deddens; U Latza; X Baur; D Heederik
Journal:  Occup Environ Med       Date:  2006-05-25       Impact factor: 4.402

3.  Respiratory symptoms, sensitization, and exposure response relationships in spray painters exposed to isocyanates.

Authors:  Anjoeka Pronk; Liesbeth Preller; Monika Raulf-Heimsoth; Irene C L Jonkers; Jan-Willem Lammers; Inge M Wouters; Gert Doekes; Adam V Wisnewski; Dick Heederik
Journal:  Am J Respir Crit Care Med       Date:  2007-07-26       Impact factor: 21.405

Review 4.  The role of non-P450 enzymes in drug oxidation.

Authors:  C Beedham
Journal:  Pharm World Sci       Date:  1997-12

5.  Urinary hexane diamine as an indicator of occupational exposure to hexamethylene diisocyanate.

Authors:  A Maître; M Berode; A Perdrix; M Stoklov; J M Mallion; H Savolainen
Journal:  Int Arch Occup Environ Health       Date:  1996       Impact factor: 3.015

6.  Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate.

Authors:  C A Redlich; M H Karol; C Graham; R J Homer; C T Holm; J A Wirth; M R Cullen
Journal:  Scand J Work Environ Health       Date:  1997-06       Impact factor: 5.024

7.  Isocyanate exposures in autobody shop work: the SPRAY study.

Authors:  Judy Sparer; Meredith H Stowe; Dhimiter Bello; Youcheng Liu; Rebecca J Gore; Fred Youngs; Mark R Cullen; Carrie A Redlich; Susan R Woskie
Journal:  J Occup Environ Hyg       Date:  2004-09       Impact factor: 2.155

8.  Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs.

Authors:  D Zissu; S Binet; J C Limasset
Journal:  Contact Dermatitis       Date:  1998-11       Impact factor: 6.600

9.  Kinetics and mechanistic studies of the hydrolysis of diisocyanate-derived bis-thiocarbamates of cysteine methyl ester.

Authors:  Itai Chipinda; Sarah J Stetson; Gary J Depree; Reuben H Simoyi; Paul D Siegel
Journal:  Chem Res Toxicol       Date:  2006-03       Impact factor: 3.739

10.  Test chamber exposure of humans to 1,6-hexamethylene diisocyanate and isophorone diisocyanate.

Authors:  H Tinnerberg; G Skarping; M Dalene; L Hagmar
Journal:  Int Arch Occup Environ Health       Date:  1995       Impact factor: 3.015
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  6 in total

1.  Trisaminohexyl isocyanurate, a urinary biomarker of HDI isocyanurate exposure.

Authors:  Zachary Robbins; Wanda Bodnar; Zhenfa Zhang; Avram Gold; Leena A Nylander-French
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2018-01-31       Impact factor: 3.205

2.  Characterization of methylene diphenyl diisocyanate-haptenated human serum albumin and hemoglobin.

Authors:  Morgen Mhike; Itai Chipinda; Justin M Hettick; Reuben H Simoyi; Angela Lemons; Brett J Green; Paul D Siegel
Journal:  Anal Biochem       Date:  2013-06-04       Impact factor: 3.365

3.  DNA methylation modifies urine biomarker levels in 1,6-hexamethylene diisocyanate exposed workers: a pilot study.

Authors:  Leena A Nylander-French; Michael C Wu; John E French; Jayne C Boyer; Lisa Smeester; Alison P Sanders; Rebecca C Fry
Journal:  Toxicol Lett       Date:  2014-10-22       Impact factor: 4.372

4.  Biomonitoring for Occupational Exposure to Diisocyanates: A Systematic Review.

Authors:  Bernice Scholten; Laura Kenny; Radu-Corneliu Duca; Anjoeka Pronk; Tiina Santonen; Karen S Galea; Miranda Loh; Katriina Huumonen; Anne Sleeuwenhoek; Matteo Creta; Lode Godderis; Kate Jones
Journal:  Ann Work Expo Health       Date:  2020-07-01       Impact factor: 2.179

5.  Viability of cultured human skin cells treated with 1,6-hexamethylene diisocyanate monomer and its oligomer isocyanurate in different culture media.

Authors:  Jayne C Boyer; Laura W Taylor; Leena A Nylander-French
Journal:  Sci Rep       Date:  2021-12-10       Impact factor: 4.379

6.  Epigenetic Markers Are Associated With Differences in Isocyanate Biomarker Levels in Exposed Spray-Painters.

Authors:  Laura W Taylor; John E French; Zachary G Robbins; Leena A Nylander-French
Journal:  Front Genet       Date:  2021-07-14       Impact factor: 4.599
  6 in total

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