Literature DB >> 15559329

Isocyanate exposures in autobody shop work: the SPRAY study.

Judy Sparer1, Meredith H Stowe, Dhimiter Bello, Youcheng Liu, Rebecca J Gore, Fred Youngs, Mark R Cullen, Carrie A Redlich, Susan R Woskie.   

Abstract

Isocyanates, known to cause respiratory sensitization and asthma, are widely used in automotive refinishing where exposures to aliphatic polyisocyanates occur by both inhalation and skin contact. The work reported here, the characterization of isocyanate exposure in the autobody industry, was part of an epidemiologic study of workers in 37 autobody shops in Connecticut. This article describes workplaces, tasks, and controls, and outlines the frequency, duration, and intensity of isocyanate exposures. Personal air samples taken outside of respirators had median concentrations of 66.5 microg NCO/m3 for primer, 134.4 microg (NCO)/m3 for sealer, and 358.5 microg NCO/m3 for clearcoat. Forty-eight percent of primer, 66% of sealer, and 92% of clearcoat samples exceeded the United Kingdom Health and Safety Executive guideline for isocyanate, though none exceeded the National Institute for Occupational Safety and Health (NIOSH) recommended exposure limit for monomer. Nonisocyanate-containing primers and sealers are used in more than half the shops, but nonisocyanate clearcoats are rare. Eighty-two percent of personal samples taken within a spray booth exceeded the U.K. guideline: 81% of those in downdraft spray booths, 74% in semidowndraft booths, and 92% in crossdraft booths. Only 8% of shops reported that spraying is done exclusively in spray booths. All painters wore some type of respirator. In 30% of shops, painters used supplied air respirators; the rest relied on half face organic vapor cartridge respirators with N95 overspray pads. All shops provided some type of gloves, usually latex, not recommended for isocyanate protection. Despite improvements in autobody shop materials, practices, and controls, there are still opportunities for substantial exposures to isocyanates.

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Year:  2004        PMID: 15559329     DOI: 10.1080/15459620490485909

Source DB:  PubMed          Journal:  J Occup Environ Hyg        ISSN: 1545-9624            Impact factor:   2.155


  15 in total

1.  Airborne isocyanate exposures in the collision repair industry and a comparison to occupational exposure limits.

Authors:  Carolyn Reeb-Whitaker; Stephen G Whittaker; Diana M Ceballos; Elisa C Weiland; Sheila L Flack; Kenneth W Fent; Jennifer M Thomasen; Linda G Trelles Gaines; Leena A Nylander-French
Journal:  J Occup Environ Hyg       Date:  2012       Impact factor: 2.155

2.  Indoor air pollution evaluation with emphasize on HDI and biological assessment of HDA in the polyurethane factories.

Authors:  Mirtaghi Mirmohammadi; M Hakimi Ibrahim; Anees Ahmad; Mohd Omar Abdul Kadir; M Mohammadyan; S B Mirashrafi
Journal:  Environ Monit Assess       Date:  2009-05-15       Impact factor: 2.513

3.  Skin exposure to aliphatic polyisocyanates in the auto body repair and refinishing industry: III. A personal exposure algorithm.

Authors:  Youcheng Liu; Meredith H Stowe; Dhimiter Bello; Judy Sparer; Rebecca J Gore; Mark R Cullen; Carrie A Redlich; Susan R Woskie
Journal:  Ann Occup Hyg       Date:  2008-11-14

4.  A murine monoclonal antibody with broad specificity for occupationally relevant diisocyanates.

Authors:  Angela R Lemons; Paul D Siegel; Morgen Mhike; Brandon F Law; Justin M Hettick; Toni A Bledsoe; Ajay P Nayak; Donald H Beezhold; Brett J Green
Journal:  J Occup Environ Hyg       Date:  2014       Impact factor: 2.155

5.  Biomonitoring Hexamethylene diisocyanate (HDI) exposure based on serum levels of HDI-specific IgG.

Authors:  Adam V Wisnewski; Meredith H Stowe; Abby Nerlinger; Paul Opare-Addo; David Decamp; Christopher R Kleinsmith; Carrie A Redlich
Journal:  Ann Occup Hyg       Date:  2012-03-26

6.  Reaction products of hexamethylene diisocyanate vapors with "self" molecules in the airways of rabbits exposed via tracheostomy.

Authors:  Adam V Wisnewski; Jean Kanyo; Jennifer Asher; James A Goodrich; Grace Barnett; Lyn Patrylak; Jian Liu; Carrie A Redlich; Ala F Nassar
Journal:  Xenobiotica       Date:  2017-06-01       Impact factor: 1.908

7.  Understanding factors that influence protective glove use among automotive spray painters.

Authors:  Diana Ceballos; Carolyn Reeb-Whitaker; Patricia Glazer; Helen Murphy-Robinson; Michael Yost
Journal:  J Occup Environ Hyg       Date:  2014       Impact factor: 2.155

8.  Quantification and statistical modeling--part I: breathing-zone concentrations of monomeric and polymeric 1,6-hexamethylene diisocyanate.

Authors:  Kenneth W Fent; Linda G Trelles Gaines; Jennifer M Thomasen; Sheila L Flack; Kai Ding; Amy H Herring; Stephen G Whittaker; Leena A Nylander-French
Journal:  Ann Occup Hyg       Date:  2009-07-21

9.  Quantification and statistical modeling--part II: dermal concentrations of monomeric and polymeric 1,6-hexamethylene diisocyanate.

Authors:  Kenneth W Fent; Linda G Trelles Gaines; Jennifer M Thomasen; Sheila L Flack; Kai Ding; Amy H Herring; Stephen G Whittaker; Leena A Nylander-French
Journal:  Ann Occup Hyg       Date:  2009-07-27

10.  Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI-albumin conjugates.

Authors:  A V Wisnewski; Q Liu; J Liu; C A Redlich
Journal:  Clin Exp Allergy       Date:  2008-06       Impact factor: 5.018

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