BACKGROUND:Parkinsonian dysarthria (as typically characterized by hypophonia, monotony of pitch, and rhythm abnormalities) is often accompanied by gait disturbances. The long-term effect of subthalamic nucleus deep brain stimulation (STN DBS) on dysarthria remains unclear. METHODS: Given STN DBS's known improvement of gait disorders, we analyzed speech intelligibility and aerodynamic and acoustic parameters in 11 advanced PD patients in three double-blind, randomized conditions: "defined Off," 60 Hz STN DBS and 130 Hz STN DBS. RESULTS: An improvement in aerodynamic speech parameters during 60 Hz STN DBS was accompanied by significant clinical benefit. CONCLUSIONS: Chronic treatment with low-frequency STN DBS may have a beneficial impact on dysarthropneumophonia, even in advanced PD patients.
RCT Entities:
BACKGROUND:Parkinsonian dysarthria (as typically characterized by hypophonia, monotony of pitch, and rhythm abnormalities) is often accompanied by gait disturbances. The long-term effect of subthalamic nucleus deep brain stimulation (STNDBS) on dysarthria remains unclear. METHODS: Given STNDBS's known improvement of gait disorders, we analyzed speech intelligibility and aerodynamic and acoustic parameters in 11 advanced PDpatients in three double-blind, randomized conditions: "defined Off," 60 Hz STNDBS and 130 Hz STNDBS. RESULTS: An improvement in aerodynamic speech parameters during 60 Hz STNDBS was accompanied by significant clinical benefit. CONCLUSIONS: Chronic treatment with low-frequency STNDBS may have a beneficial impact on dysarthropneumophonia, even in advanced PDpatients.
Authors: Tao Xie; Julie Vigil; Ellen MacCracken; Arunas Gasparaitis; Joan Young; Wenjun Kang; Jacqueline Bernard; Peter Warnke; Un J Kang Journal: Neurology Date: 2014-12-24 Impact factor: 9.910
Authors: Zachary J Conway; Peter A Silburn; Wesley Thevathasan; Karen O' Maley; Geraldine A Naughton; Michael H Cole Journal: Mov Disord Clin Pract Date: 2018-11-08
Authors: Zack Blumenfeld; Anca Velisar; Mandy Miller Koop; Bruce C Hill; Lauren A Shreve; Emma J Quinn; Camilla Kilbane; Hong Yu; Jaimie M Henderson; Helen Brontë-Stewart Journal: PLoS One Date: 2015-03-25 Impact factor: 3.240