Literature DB >> 21504840

Enhancement of psychotherapy using epigenetic modulating drugs.

David P Gavin1, Kayla A Chase, Rajiv P Sharma.   

Abstract

Recent evidence suggests that covalent modifications to the genomic platform in the brain, that is DNA and its surrounding histones, provide a stable potentially lifelong mechanism for remembrance. Consequently, the making and unmaking of memories is accessible through pharmacological manipulations of these modifications. This has implications for psychotherapy and long-term rehabilitation of CNS disorders. We hypothesize that by enhancing learning through pharmacologically manipulating 'epigenetic' parameters, the effects of psychotherapies and rehabilitation can be enhanced.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21504840      PMCID： PMC3110602          DOI： 10.1016/j.mehy.2011.03.042

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN： 0306-9877            Impact factor:   1.538


  46 in total

1.  Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission.

Authors:  Vardhman K Rakyan; Suyinn Chong; Marnie E Champ; Peter C Cuthbert; Hugh D Morgan; Keith V K Luu; Emma Whitelaw
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-24       Impact factor: 11.205

Review 2.  Cellular memory and the histone code.

Authors:  Bryan M Turner
Journal:  Cell       Date:  2002-11-01       Impact factor: 41.582

3.  Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.

Authors:  Victoria V Lunyak; Robert Burgess; Gratien G Prefontaine; Charles Nelson; Sing-Hoi Sze; Josh Chenoweth; Phillip Schwartz; Pavel A Pevzner; Christopher Glass; Gail Mandel; Michael G Rosenfeld
Journal:  Science       Date:  2002-10-24       Impact factor: 47.728

4.  Regulation of histone acetylation during memory formation in the hippocampus.

Authors:  Jonathan M Levenson; Kenneth J O'Riordan; Karen D Brown; Mimi A Trinh; David L Molfese; J David Sweatt
Journal:  J Biol Chem       Date:  2004-07-23       Impact factor: 5.157

5.  Acetylation of nuclear factor-kappaB in rat amygdala improves long-term but not short-term retention of fear memory.

Authors:  Shiu-Hwa Yeh; Chia-Ho Lin; Po-Wu Gean
Journal:  Mol Pharmacol       Date:  2004-05       Impact factor: 4.436

6.  Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life.

Authors:  Ian C G Weaver; Frances A Champagne; Shelley E Brown; Sergiy Dymov; Shakti Sharma; Michael J Meaney; Moshe Szyf
Journal:  J Neurosci       Date:  2005-11-23       Impact factor: 6.167

7.  Efficacy of rehabilitative experience declines with time after focal ischemic brain injury.

Authors:  Jeff Biernaskie; Garry Chernenko; Dale Corbett
Journal:  J Neurosci       Date:  2004-02-04       Impact factor: 6.167

8.  Sodium 4-phenylbutyrate protects against cerebral ischemic injury.

Authors:  Xin Qi; Toru Hosoi; Yasunobu Okuma; Masayuki Kaneko; Yasuyuki Nomura
Journal:  Mol Pharmacol       Date:  2004-06-29       Impact factor: 4.436

9.  Epigenetic programming by maternal behavior.

Authors:  Ian C G Weaver; Nadia Cervoni; Frances A Champagne; Ana C D'Alessio; Shakti Sharma; Jonathan R Seckl; Sergiy Dymov; Moshe Szyf; Michael J Meaney
Journal:  Nat Neurosci       Date:  2004-06-27       Impact factor: 24.884

10.  Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction.

Authors:  Ming Ren; Yan Leng; MiRa Jeong; Peter R Leeds; De-Maw Chuang
Journal:  J Neurochem       Date:  2004-06       Impact factor: 5.372
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  3 in total

Review 1.  Epigenetic and Neural Circuitry Landscape of Psychotherapeutic Interventions.

Authors:  Christopher W T Miller
Journal:  Psychiatry J       Date:  2017-05-25

2.  Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis.

Authors:  David P Gavin; Rajiv P Sharma; Kayla A Chase; Francesco Matrisciano; Erbo Dong; Alessandro Guidotti
Journal:  Neuropsychopharmacology       Date:  2011-11-02       Impact factor: 7.853

Review 3.  Psychotherapy and Genetic Neuroscience: An Emerging Dialog.

Authors:  Juan P Jiménez; Alberto Botto; Luisa Herrera; Caroline Leighton; José L Rossi; Yamil Quevedo; Jaime R Silva; Felipe Martínez; Rodrigo Assar; Luis A Salazar; Manuel Ortiz; Ulises Ríos; Paulina Barros; Karina Jaramillo; Patrick Luyten
Journal:  Front Genet       Date:  2018-07-17       Impact factor: 4.599
  3 in total

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