Literature DB >> 21504827

DNA damage discrimination at stalled replication forks by the Rad5 homologs HLTF and SHPRH.

George-Lucian Moldovan1, Alan D D'Andrea.   

Abstract

In this issue of Molecular Cell, Lin et al. (2011) describe how HLTF and SHPRH, the human homologs of yeast Rad5, can discriminate between MMS-induced versus UV-induced DNA damage. The results have important implications for the suppression of damage-specific mutagenesis and for the maintenance of genomic stability.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID: 21504827     DOI: 10.1016/j.molcel.2011.03.018

Source DB:  PubMed          Journal:  Mol Cell        ISSN: 1097-2765            Impact factor:   17.970


  6 in total

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  6 in total

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