Literature DB >> 21499643

Structure-guided redesign of D-fructose-6-phosphate aldolase from E. coli: remarkable activity and selectivity towards acceptor substrates by two-point mutation.

Mariana Gutierrez1, Teodor Parella, Jesús Joglar, Jordi Bujons, Pere Clapés.   

Abstract

Structure-guided re-design of the acceptor binding site of D-fructose-6-phosphate aldolase from E. coli leads to the construction of FSA A129S/A165G double mutant with an activity between 5- to >900-fold higher than that of wild-type towards N-Cbz-aminoaldehyde derivatives. © The Royal Society of Chemistry 2011

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Year:  2011        PMID： 21499643     DOI： 10.1039/c1cc11069a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Asymmetric assembly of aldose carbohydrates from formaldehyde and glycolaldehyde by tandem biocatalytic aldol reactions.

Authors:  Anna Szekrenyi; Xavier Garrabou; Teodor Parella; Jesús Joglar; Jordi Bujons; Pere Clapés
Journal:  Nat Chem       Date:  2015-08-10       Impact factor: 24.427

Review 2.  Rational approaches for engineering novel functionalities in carbon-carbon bond forming enzymes.

Authors:  Perrin Baker; Stephen Y K Seah
Journal:  Comput Struct Biotechnol J       Date:  2012-10-02       Impact factor: 7.271

Review 3.  Engineering aldolases as biocatalysts.

Authors:  Claire L Windle; Marion Müller; Adam Nelson; Alan Berry
Journal:  Curr Opin Chem Biol       Date:  2014-01-04       Impact factor: 8.822

Review 4.  Building Bridges: Biocatalytic C-C-Bond Formation toward Multifunctional Products.

Authors:  Nina G Schmidt; Elisabeth Eger; Wolfgang Kroutil
Journal:  ACS Catal       Date:  2016-06-08       Impact factor: 13.084

5.  Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes.

Authors:  Raquel Roldán; Karel Hernández; Jesús Joglar; Jordi Bujons; Teodor Parella; Wolf-Dieter Fessner; Pere Clapés
Journal:  Adv Synth Catal       Date:  2019-02-15       Impact factor: 5.837

Review 6.  Progress in Stereoselective Construction of C-C Bonds Enabled by Aldolases and Hydroxynitrile Lyases.

Authors:  Mi Liu; Dan Wei; Zexing Wen; Jian-Bo Wang
Journal:  Front Bioeng Biotechnol       Date:  2021-04-21

7.  Highly stereoselective biosynthesis of (R)-α-hydroxy carboxylic acids through rationally re-designed mutation of D-lactate dehydrogenase.

Authors:  Zhaojuan Zheng; Binbin Sheng; Chao Gao; Haiwei Zhang; Tong Qin; Cuiqing Ma; Ping Xu
Journal:  Sci Rep       Date:  2013-12-02       Impact factor: 4.379
  7 in total

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