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Literature DB >> 21498764

Antimicrobial effect of chitosan nanoparticles on streptococcus mutans biofilms.

Luis E Chávez de Paz¹, Anton Resin, Kenneth A Howard, Duncan S Sutherland, Peter L Wejse.

Abstract

Nanoparticle complexes were prepared from chitosans of various molecular weights (MW) and degrees of deacetylation (DD). The antimicrobial effect was assessed by the Live/Dead BacLight technique in conjunction with confocal scanning laser microscopy (CSLM) and image analysis. Nanocomplexes prepared from chitosans with high MW showed a low antimicrobial effect (20 to 25% of cells damaged), whereas those prepared from low-MW chitosans showed high antimicrobial effect (>95% of cells damaged).

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Year: 2011 PMID： 21498764 PMCID： PMC3127608 DOI： 10.1128/AEM.02941-10

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

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