Literature DB >> 21497618

Philadelphicalactones C and D and other cytotoxic compounds from Physalis philadelphica.

Emma Maldonado1, Ana L Pérez-Castorena, Consuelo Garcés, Mahinda Martínez.   

Abstract

Two new withanolides, philadelphicalactone C (1) and philadelphicalactone D (4), along with the known withaphysacarpin (3), ixocarpanolide (5), philadelphicalactone A (6), and ixocarpalactone A (7) were isolated from the aerial parts of Physalis philadelphica Lam. Structures of these compounds were determined by spectroscopic analyses and that of philadelphicalactone C (1) was confirmed by X-ray crystallographic analysis. Evaluation of the cytotoxic activity of all isolates and the derivative 2 against a panel of human cancer cell lines indicated a potent activity of compounds 2, 3, 6, and 7.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21497618     DOI： 10.1016/j.steroids.2011.03.018

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  7 in total

1.  Metabolic response to larval herbivory in three Physalis species.

Authors:  Verónica Trujillo-Pahua; Ofelia Vargas-Ponce; Fabián A Rodríguez-Zaragoza; José J Ordaz-Ortiz; John P Délano-Frier; Robert Winkler; Carla V Sánchez-Hernández
Journal:  Plant Signal Behav       Date:  2021-08-26

2.  Correction.

Authors: 
Journal:  Plant Signal Behav       Date:  2021-10-06

3.  New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells.

Authors:  Meng Zhang; Bingyang Zhang; Chenxi Guang; Benke Jiang; Xinya He; Shijie Cao; Liqin Ding; Ning Kang; Lixia Chen; Feng Qiu
Journal:  RSC Adv       Date:  2020-06-16       Impact factor: 4.036

4.  Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica.

Authors:  Ya-Ming Xu; E M Kithsiri Wijeratne; Alan D Brooks; Poonam Tewary; Li-Jiang Xuan; Wen-Qiong Wang; Thomas J Sayers; A A Leslie Gunatilaka
Journal:  Phytochemistry       Date:  2018-05-21       Impact factor: 4.072

5.  Genetic diversity and population structure in Physalis peruviana and related taxa based on InDels and SNPs derived from COSII and IRG markers.

Authors:  Gina A Garzón-Martínez; Jaime A Osorio-Guarín; Paola Delgadillo-Durán; Franklin Mayorga; Felix E Enciso-Rodríguez; David Landsman; Leonardo Mariño-Ramírez; Luz Stella Barrero
Journal:  Plant Gene       Date:  2015-12-01

6.  Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl.

Authors:  Ya-Ming Xu; E M Kithsiri Wijeratne; Manping X Liu; Lijiang Xuan; Wenqiong Wang; A A Leslie Gunatilaka
Journal:  Molecules       Date:  2022-01-28       Impact factor: 4.411

7.  Anti-proliferative withanolides from the Solanaceae: a structure-activity study.

Authors:  Huaping Zhang; Abbas K Samadi; Mark S Cohen; Barbara N Timmermann
Journal:  Pure Appl Chem       Date:  2012       Impact factor: 2.453
  7 in total

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