Jonathan B Waugh1, Chad A Epps, Yulia A Khodneva. 1. Department of Clinical and Diagnostic Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294, USA. waughj@uab.edu
Abstract
STUDY OBJECTIVE: To determine if capnography, in addition to standard monitoring, identified more respiratory complications than standard monitoring alone. DESIGN: Meta-analysis. SETTING: University medical center. MEASUREMENTS: The electronic databases PubMed, CINAHL, and Cochrane Library (Cochrane Reviews, CENTRAL) were searched for studies published between 1995-2009 reporting adverse respiratory events during procedural sedation and analgesia (PSA) with clearly defined end-tidal carbon dioxide threshold, adult population, clear study design, P-value calculation, similar outcome and predictor variable definitions, and binary independent and dependent variable raw data. Five such studies were evaluated independently. A meta-analysis of these studies was performed. MAIN RESULTS: During PSA, cases of respiratory depression were 17.6 times more likely to be detected if monitored by capnography than cases not monitored by capnography (95% CI, 2.5-122.1; P < 0.004). CONCLUSION: End-tidal carbon dioxide monitoring is an important addition in detecting respiratory depression during PSA.
STUDY OBJECTIVE: To determine if capnography, in addition to standard monitoring, identified more respiratory complications than standard monitoring alone. DESIGN: Meta-analysis. SETTING: University medical center. MEASUREMENTS: The electronic databases PubMed, CINAHL, and Cochrane Library (Cochrane Reviews, CENTRAL) were searched for studies published between 1995-2009 reporting adverse respiratory events during procedural sedation and analgesia (PSA) with clearly defined end-tidal carbon dioxide threshold, adult population, clear study design, P-value calculation, similar outcome and predictor variable definitions, and binary independent and dependent variable raw data. Five such studies were evaluated independently. A meta-analysis of these studies was performed. MAIN RESULTS: During PSA, cases of respiratory depression were 17.6 times more likely to be detected if monitored by capnography than cases not monitored by capnography (95% CI, 2.5-122.1; P < 0.004). CONCLUSION: End-tidal carbon dioxide monitoring is an important addition in detecting respiratory depression during PSA.
Authors: Christoph Schlag; Alexandra Wörner; Stefan Wagenpfeil; Eberhard F Kochs; Roland M Schmid; Stefan von Delius Journal: Can J Gastroenterol Date: 2013-10 Impact factor: 3.522
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