PURPOSE: Oxidative stress is implicated in prostate cancer by several lines of evidence. We studied the relationship between the level of F2-isoprostanes, a validated biomarker of oxidative stress, and prostate cancer and high grade prostatic intraepithelial neoplasia. MATERIALS AND METHODS: This case-control analysis within the Nashville Men's Health Study included men recruited at prostate biopsy. Body morphometrics, health history and urine were collected from more than 2,000 men before biopsy. F2-isoprostanes were measured by gas chromatography/mass spectrometry within an age matched sample of Nashville Men's Health Study participants that included 140 patients with high grade prostatic intraepithelial neoplasia, 160 biopsy negative controls and 200 prostate cancer cases. Multivariable linear and logistic regression was used to determine the associations between F2-isoprostane level, and high grade prostatic intraepithelial neoplasia and prostate cancer. RESULTS: Mean patient age was 66.9 years (SD 7.2) and 10.1% were nonwhite. Adjusted geometric mean F2-isoprostane levels were higher in patients with prostate cancer (1.82, 95% CI 1.66-2.00) or high grade prostatic intraepithelial neoplasia (1.82, 95% CI 1.68-1.96) than in controls (1.63, 95% CI 1.49-1.78, p <0.001), but were similar across Gleason scores (p = 0.511). The adjusted odds of high grade prostatic intraepithelial neoplasia and prostate cancer increased with increasing F2-isoprostane quartile (p-trend = 0.015 and 0.047, respectively) and the highest F2-isoprostane quartile was associated with significantly increased odds of prostate cancer (OR 2.44, 95% CI 1.17-5.09, p = 0.017). CONCLUSIONS: Pre-diagnosis urine F2-isoprostane level is increased in men with high grade prostatic intraepithelial neoplasia or prostate cancer, suggesting urinary F2-isoprostane provides a biomarker for the role for oxidative stress in prostate carcinogenesis. F2-isoprostanes may also serve to estimate the efficacy of interventions targeting oxidative stress mechanisms in prostate cancer prevention or treatment.
PURPOSE:Oxidative stress is implicated in prostate cancer by several lines of evidence. We studied the relationship between the level of F2-isoprostanes, a validated biomarker of oxidative stress, and prostate cancer and high grade prostatic intraepithelial neoplasia. MATERIALS AND METHODS: This case-control analysis within the Nashville Men's Health Study included men recruited at prostate biopsy. Body morphometrics, health history and urine were collected from more than 2,000 men before biopsy. F2-isoprostanes were measured by gas chromatography/mass spectrometry within an age matched sample of Nashville Men's Health Study participants that included 140 patients with high grade prostatic intraepithelial neoplasia, 160 biopsy negative controls and 200 prostate cancer cases. Multivariable linear and logistic regression was used to determine the associations between F2-isoprostane level, and high grade prostatic intraepithelial neoplasia and prostate cancer. RESULTS: Mean patient age was 66.9 years (SD 7.2) and 10.1% were nonwhite. Adjusted geometric mean F2-isoprostane levels were higher in patients with prostate cancer (1.82, 95% CI 1.66-2.00) or high grade prostatic intraepithelial neoplasia (1.82, 95% CI 1.68-1.96) than in controls (1.63, 95% CI 1.49-1.78, p <0.001), but were similar across Gleason scores (p = 0.511). The adjusted odds of high grade prostatic intraepithelial neoplasia and prostate cancer increased with increasing F2-isoprostane quartile (p-trend = 0.015 and 0.047, respectively) and the highest F2-isoprostane quartile was associated with significantly increased odds of prostate cancer (OR 2.44, 95% CI 1.17-5.09, p = 0.017). CONCLUSIONS: Pre-diagnosis urine F2-isoprostane level is increased in men with high grade prostatic intraepithelial neoplasia or prostate cancer, suggesting urinary F2-isoprostane provides a biomarker for the role for oxidative stress in prostate carcinogenesis. F2-isoprostanes may also serve to estimate the efficacy of interventions targeting oxidative stress mechanisms in prostate cancer prevention or treatment.
Authors: D G Bostwick; E E Alexander; R Singh; A Shan; J Qian; R M Santella; L W Oberley; T Yan; W Zhong; X Jiang; T D Oberley Journal: Cancer Date: 2000-07-01 Impact factor: 6.860
Authors: L C Clark; G F Combs; B W Turnbull; E H Slate; D K Chalker; J Chow; L S Davis; R A Glover; G F Graham; E G Gross; A Krongrad; J L Lesher; H K Park; B B Sanders; C L Smith; J R Taylor Journal: JAMA Date: 1996-12-25 Impact factor: 56.272
Authors: Hirak S Basu; Todd A Thompson; Dawn R Church; Cynthia C Clower; Farideh Mehraein-Ghomi; Corey A Amlong; Christopher T Martin; Patrick M Woster; Mary J Lindstrom; George Wilding Journal: Cancer Res Date: 2009-09-22 Impact factor: 12.701
Authors: Donald C McMillan; Dinesh Talwar; Naveed Sattar; Mark Underwood; Denis St J O'Reilly; Colin McArdle Journal: Clin Nutr Date: 2002-04 Impact factor: 7.324
Authors: Daniel R Cottam; Samer G Mattar; Emma Barinas-Mitchell; George Eid; Lewis Kuller; David E Kelley; Philip R Schauer Journal: Obes Surg Date: 2004-05 Impact factor: 4.129
Authors: Stephen J Freedland; William J Aronson; Christopher J Kane; Joseph C Presti; Christopher L Amling; David Elashoff; Martha K Terris Journal: J Clin Oncol Date: 2003-12-22 Impact factor: 44.544
Authors: Marilyn J Hockenberry; Olga A Taylor; Patricia M Gundy; Adam K Ross; Alice Pasvogel; David Montgomery; Phillip Ribbeck; Kathy McCarthy; Ida Moore Journal: Biol Res Nurs Date: 2013-08-15 Impact factor: 2.522
Authors: Jian-Min Yuan; Menno Grouls; Steven G Carmella; Renwei Wang; Alisa Heskin; Yang Jiang; Yu-Ting Tan; Jennifer Adams-Haduch; Yu-Tang Gao; Stephen S Hecht Journal: Carcinogenesis Date: 2019-08-22 Impact factor: 4.944
Authors: Akwi W Asombang; Violet Kayamba; Mpala Mwanza-Lisulo; Graham Colditz; Victor Mudenda; Kevin Yarasheski; Robert Chott; Deborah C Rubin; C Prakash Gyawali; Edford Sinkala; Stayner Mwanamakondo; Catherine Anderson-Spearie; Paul Kelly Journal: Am J Clin Nutr Date: 2013-03-27 Impact factor: 7.045
Authors: Akwi W Asombang; Violet Kayamba; Mpala M Lisulo; Kathryn Trinkaus; Victor Mudenda; Edford Sinkala; Stayner Mwanamakondo; Themba Banda; Rose Soko; Paul Kelly Journal: World J Gastroenterol Date: 2016-03-07 Impact factor: 5.742