Literature DB >> 21495708

Bifacial nucleoside as a surrogate for both T and A in duplex DNA.

Dongwon Shin1, Yitzhak Tor.   

Abstract

A new functional bifacial nucleoside derived from 7-aminopyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione, a Janus-type nucleobase, has been synthesized and incorporated into DNA oligonucleotides. The nucleobase, having self-complementary H-bonding faces, mimics both T and A and engages in the corresponding Watson-Crick-like base pairs, forming stable duplexes.
© 2011 American Chemical Society

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Year:  2011        PMID： 21495708      PMCID： PMC3093761          DOI： 10.1021/ja201397e

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  33 in total

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5.  A synthetic nucleoside probe that discerns a DNA adduct from unmodified DNA.

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Journal:  J Am Chem Soc       Date:  2007-04-03       Impact factor: 15.419

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8.  Synthesis and properties of defined DNA oligomers containing base mispairs involving 2-aminopurine.

Authors:  R Eritja; B E Kaplan; D Mhaskar; L C Sowers; J Petruska; M F Goodman
Journal:  Nucleic Acids Res       Date:  1986-07-25       Impact factor: 16.971

9.  G--C quartet--a DNA-inspired Janus-GC heterocycle: synthesis, structural analysis, and self-organization.

Authors:  Ali Asadi; Brian O Patrick; David M Perrin
Journal:  J Am Chem Soc       Date:  2008-09-04       Impact factor: 15.419

10.  Molecular tectonics. Porous hydrogen-bonded networks built from derivatives of pentaerythrityl tetraphenyl ether.

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Review 7.  Unnatural bases for recognition of noncoding nucleic acid interfaces.

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  7 in total

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