Literature DB >> 21495622

Proteome interrogation using nanoprobes to identify targets of a cancer-killing molecule.

Liwen Li1, Qiu Zhang, Aifeng Liu, Xiue Li, Hongyu Zhou, Yin Liu, Bing Yan.   

Abstract

We report a generic approach for identification of target proteins of therapeutic molecules using nanoprobes. Nanoprobes verify the integrity of nanoparticle-bound ligands in live cells and pull down target proteins from the cellular proteome, providing very important information on drug targets and mechanisms of action. As an example, target proteins as α-tubulin and HSP 90 have been identified and validated.
© 2011 American Chemical Society

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Year:  2011        PMID： 21495622      PMCID： PMC3138543          DOI： 10.1021/ja111137n

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  24 in total

Review 1.  Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia.

Authors:  Bryan L Roth; Douglas J Sheffler; Wesley K Kroeze
Journal:  Nat Rev Drug Discov       Date:  2004-04       Impact factor: 84.694

Review 2.  Microtubules as a target for anticancer drugs.

Authors:  Mary Ann Jordan; Leslie Wilson
Journal:  Nat Rev Cancer       Date:  2004-04       Impact factor: 60.716

3.  Mechanism of inhibition of microtubule polymerization by colchicine: inhibitory potencies of unliganded colchicine and tubulin-colchicine complexes.

Authors:  D A Skoufias; L Wilson
Journal:  Biochemistry       Date:  1992-01-28       Impact factor: 3.162

Review 4.  Microtubules, microtubule-interfering agents and apoptosis.

Authors:  F Mollinedo; C Gajate
Journal:  Apoptosis       Date:  2003-10       Impact factor: 4.677

5.  An improved procedure for protein staining in polyacrylamide gels with a new type of Coomassie Brilliant Blue.

Authors:  W Diezel; G Kopperschläger; E Hofmann
Journal:  Anal Biochem       Date:  1972-08       Impact factor: 3.365

6.  Kinetics and mechanism of colchicine binding to tubulin: evidence for ligand-induced conformational change.

Authors:  D L Garland
Journal:  Biochemistry       Date:  1978-10-03       Impact factor: 3.162

Review 7.  Hsp90: a drug target?

Authors:  Jeffrey M Holzbeierlein; Andrew Windsperger; George Vielhauer
Journal:  Curr Oncol Rep       Date:  2010-03       Impact factor: 5.075

8.  Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways.

Authors:  T H Wang; H S Wang; H Ichijo; P Giannakakou; J S Foster; T Fojo; J Wimalasena
Journal:  J Biol Chem       Date:  1998-02-27       Impact factor: 5.157

9.  Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK).

Authors:  L F Lee; G Li; D J Templeton; J P Ting
Journal:  J Biol Chem       Date:  1998-10-23       Impact factor: 5.157

Review 10.  Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.

Authors:  A Jordan; J A Hadfield; N J Lawrence; A T McGown
Journal:  Med Res Rev       Date:  1998-07       Impact factor: 12.944
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  2 in total

1.  Modulation of G protein-coupled adenosine receptors by strategically functionalized agonists and antagonists immobilized on gold nanoparticles.

Authors:  P Suresh Jayasekara; Khai Phan; Dilip K Tosh; T Santhosh Kumar; Steven M Moss; Guofeng Zhang; Joseph J Barchi; Zhan-Guo Gao; Kenneth A Jacobson
Journal:  Purinergic Signal       Date:  2012-11-20       Impact factor: 3.765

2.  Synergistic action by multi-targeting compounds produces a potent compound combination for human NSCLC both in vitro and in vivo.

Authors:  C Zhang; S Zhai; X Li; Q Zhang; L Wu; Y Liu; C Jiang; H Zhou; F Li; S Zhang; G Su; B Zhang; B Yan
Journal:  Cell Death Dis       Date:  2014-03-20       Impact factor: 8.469
  2 in total

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