BACKGROUND: The objective of this study was to assess the association between preoperative circulating levels of 17β-estradiol (E₂) and high-grade prostate cancer (HGPCa) (Gleason grade ≥ 4 + 3) at the time patients underwent radical retropubic prostatectomy (RRP). METHODS: Serum total testosterone (tT), sex hormone-binding globulin (SHBG), and E₂ levels were measured the day before surgery (8-10 AM) in a cohort of 655 consecutive Caucasian- European patients who underwent RRP at a single institution. Logistic regression models were used to test the association between predictors (including age, body mass index, prostate-specific antigen [PSA], clinical tumor classification, biopsy Gleason sum, tT, SHBG, and E₂) and HGPCa. Serum E₂ was included in the model as both a continuous variable and a categorized variable (according to the most informative cutoff: 50 pg/mL). RESULTS: Pathologic HGPCa was identified in 156 patients (23.8%). Patients with HGPCa had significantly higher PSA, clinical tumor classification, and biopsy Gleason sum than those without HGPCa (all P < .001). No other significant differences were observed between groups. At univariate analysis, continuously coded E(2) was not associated significantly with HGPCa (odds ratio [OR], 1.009; P = .25), whereas patients with E₂ levels ≥ 50 pg/mL had a 3.24-fold increased risk of HGPCa (P < .001). At multivariate analysis, E₂ was associated significantly with HGPCa both as a continuous predictor (OR, 1.02; P = .04) and as a categorical predictor (OR, 3.94; P < .001) after accounting for other variables. Conversely, tT and SHBG levels were not associated significantly with HGPCa. CONCLUSIONS: E₂ was associated significantly with pathologic HGPCa, whereas SHBG and tT failed to demonstrate any association with HGPCa in patients who underwent RRP.
BACKGROUND: The objective of this study was to assess the association between preoperative circulating levels of 17β-estradiol (E₂) and high-grade prostate cancer (HGPCa) (Gleason grade ≥ 4 + 3) at the time patients underwent radical retropubic prostatectomy (RRP). METHODS: Serum total testosterone (tT), sex hormone-binding globulin (SHBG), and E₂ levels were measured the day before surgery (8-10 AM) in a cohort of 655 consecutive Caucasian- European patients who underwent RRP at a single institution. Logistic regression models were used to test the association between predictors (including age, body mass index, prostate-specific antigen [PSA], clinical tumor classification, biopsy Gleason sum, tT, SHBG, and E₂) and HGPCa. Serum E₂ was included in the model as both a continuous variable and a categorized variable (according to the most informative cutoff: 50 pg/mL). RESULTS: Pathologic HGPCa was identified in 156 patients (23.8%). Patients with HGPCa had significantly higher PSA, clinical tumor classification, and biopsy Gleason sum than those without HGPCa (all P < .001). No other significant differences were observed between groups. At univariate analysis, continuously coded E(2) was not associated significantly with HGPCa (odds ratio [OR], 1.009; P = .25), whereas patients with E₂ levels ≥ 50 pg/mL had a 3.24-fold increased risk of HGPCa (P < .001). At multivariate analysis, E₂ was associated significantly with HGPCa both as a continuous predictor (OR, 1.02; P = .04) and as a categorical predictor (OR, 3.94; P < .001) after accounting for other variables. Conversely, tT and SHBG levels were not associated significantly with HGPCa. CONCLUSIONS: E₂ was associated significantly with pathologic HGPCa, whereas SHBG and tT failed to demonstrate any association with HGPCa in patients who underwent RRP.
Authors: Andrea Salonia; Firas Abdollah; Umberto Capitanio; Andrea Gallina; Nazareno Suardi; Alberto Briganti; Giuseppe Zanni; Matteo Ferrari; Fabio Castiglione; Maria Chiara Clementi; Patrizio Rigatti; Francesco Montorsi Journal: World J Urol Date: 2012-03-24 Impact factor: 4.226
Authors: Antonio B Porcaro; Nicolò De Luyk; Paolo Corsi; Marco Sebben; Alessandro Tafuri; Giovanni Cacciamani; Davide De Marchi; Irene Tamanini; Davide Inverardi; Matteo Brunelli; Maria A Cerruto; Gian L Salvagno; Gian C Guidi; Walter Artibani Journal: Curr Urol Date: 2017-05-30
Authors: Thomas Schnoeller; Florian Jentzmik; Ludwig Rinnab; Marcus V Cronauer; Ilija Damjanoski; Friedemann Zengerling; Andreas Al Ghazal; Mark Schrader; Andres J Schrader Journal: World J Urol Date: 2012-07-05 Impact factor: 4.226
Authors: Mieke Van Hemelrijck; Karl Michaelsson; William G Nelson; Norma Kanarek; Adrian Dobs; Elizabeth A Platz; Sabine Rohrmann Journal: Aging Male Date: 2013-05-14 Impact factor: 5.892
Authors: Emanuela Taioli; Vestra Sears; Alexis Watson; Rafael E Flores-Obando; Maria D Jackson; Flora A Ukoli; Ilce M de Syllos Cólus; Pedro Fernandez; Norma McFarlane-Anderson; Elaine A Ostrander; Iara S Rodrigues; Janet L Stanford; Jack A Taylor; Marshall Tulloch-Reid; Camille C R Ragin Journal: Prostate Date: 2012-11-05 Impact factor: 4.104
Authors: Antonio B Porcaro; Aldo Petrozziello; Matteo Brunelli; Filippo Migliorini; Giovanni Cacciamani; Davide De Marchi; Nicolo' de Luyk; Irene Tamanini; Beatrice Caruso; Maria A Cerruto; Claudio Ghimenton; Walter Artibani Journal: Asian J Urol Date: 2015-11-30