OBJECTIVES: The goal of the present study is to determine whether a decline in the 1-hour postoperative parathyroid hormone (PTH) level relative to the preoperative level is predictive of hypocalcemia. METHODS: This is a retrospective study involving 142 consecutive patients who underwent total thyroidectomy. Changes in preoperative PTH levels were then compared with the 1-hour levels. RESULTS: Thirty-four of 142 patients (23.9%) who underwent total thyroidectomy developed hypocalcemia. Thirty-one of the 34 patients who became hypocalcemic had a 1-hour postoperative PTH drop of 70% or more when compared with the preoperative value (sensitivity = 91%, specificity = 98%, positive predictive value = 94%, and negative predictive value = 97%). CONCLUSION: A decline in the preoperative PTH level of 70% or greater at 1 hour following total thyroidectomy appears to be a reliable predictor of patients at risk of developing hypocalcemia. By allowing thyroid surgeons to identify these patients in the early postoperative period, calcium supplementation can be initiated sooner.
OBJECTIVES: The goal of the present study is to determine whether a decline in the 1-hour postoperative parathyroid hormone (PTH) level relative to the preoperative level is predictive of hypocalcemia. METHODS: This is a retrospective study involving 142 consecutive patients who underwent total thyroidectomy. Changes in preoperative PTH levels were then compared with the 1-hour levels. RESULTS: Thirty-four of 142 patients (23.9%) who underwent total thyroidectomy developed hypocalcemia. Thirty-one of the 34 patients who became hypocalcemic had a 1-hour postoperative PTH drop of 70% or more when compared with the preoperative value (sensitivity = 91%, specificity = 98%, positive predictive value = 94%, and negative predictive value = 97%). CONCLUSION: A decline in the preoperative PTH level of 70% or greater at 1 hour following total thyroidectomy appears to be a reliable predictor of patients at risk of developing hypocalcemia. By allowing thyroid surgeons to identify these patients in the early postoperative period, calcium supplementation can be initiated sooner.
Authors: F Tartaglia; A Giuliani; S Sorrenti; L Tromba; S Carbotta; A Maturo; G Carbotta; L De Anna; R Merola; G Livadoti; F Pelle; S Ulisse Journal: G Chir Date: 2016 Nov-Dec
Authors: F Schlottmann; A L Campos Arbulú; E E Sadava; P Mendez; L Pereyra; J M Fernández Vila; N A Mezzadri Journal: Langenbecks Arch Surg Date: 2015-09-11 Impact factor: 3.445
Authors: Kathrin Nagel; Anne Hendricks; Christina Lenschow; Michael Meir; Stefanie Hahner; Martin Fassnacht; Armin Wiegering; Christoph-Thomas Germer; Nicolas Schlegel Journal: BJS Open Date: 2022-09-02