Kassiani Kakava1, Symeon Tournis2, Konstantinos Makris3, Georgios Papadakis4, Evanthia Kassi5, Ismene Dontas2, Theodore Karatzas6. 1. Head and Neck Surgery Department of Metaxa Anti-Cancer Hospital, Pireaus, Greece kassianh7882@gmail.com. 2. Laboratory for the Research of the Musculoskeletal System "Th. Garofalidis", School of Medicine, National and Kapodistrian University of Athens, KAT Hospital, Athens, Greece. 3. Department of Clinical Biochemistry, KAT General Hospital, Athens, Greece. 4. STEPS Stoffwechselzentrum, Biel/Bienne, Switzerland. 5. Endocrinology Unit, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece. 6. 2 Propaedeutic Department of Surgery, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
Abstract
BACKGROUND/AIM: Postsurgical hypoparathyroidism (PostHypo) is a common complication after total thyroidectomy. We studied the risk factors associated with PostHypo. PATIENTS AND METHODS: The study included 109 women, (mean age: 50.7±10.75 years), who underwent total thyroidectomy for thyroid diseases. RESULTS: Based on the development of biochemical hypocalcemia on the first postoperative day following total thyroidectomy, (cCa<8.4 mg/dl), 37 women developed PostHypo and 72 did not. Younger age, a lower preoperative corrected calcium and the presence of parathyroid glands in the specimens were related to the development of PostHypo. Of all patients, 51.4% had a vitamin D deficiency. A parathyroid hormone (PTH) value ≤9.4 pg/ml was 84.9% sensitive and 71.4% specific to predict PostHypo on the 1st postoperative day. A 50% reduction of the PTH value on the 1st postoperative day from the preoperative level could identify patients who develop PostHypo with 76% sensitivity and 75% specificity. CONCLUSION: PTH postoperative measurement and its alteration from the preoperative level can be used to identify patients who are at increased risk to develop PostHypo. Copyright
BACKGROUND/AIM: Postsurgical hypoparathyroidism (PostHypo) is a common complication after total thyroidectomy. We studied the risk factors associated with PostHypo. PATIENTS AND METHODS: The study included 109 women, (mean age: 50.7±10.75 years), who underwent total thyroidectomy for thyroid diseases. RESULTS: Based on the development of biochemical hypocalcemia on the first postoperative day following total thyroidectomy, (cCa<8.4 mg/dl), 37 women developed PostHypo and 72 did not. Younger age, a lower preoperative corrected calcium and the presence of parathyroid glands in the specimens were related to the development of PostHypo. Of all patients, 51.4% had a vitamin D deficiency. A parathyroid hormone (PTH) value ≤9.4 pg/ml was 84.9% sensitive and 71.4% specific to predict PostHypo on the 1st postoperative day. A 50% reduction of the PTH value on the 1st postoperative day from the preoperative level could identify patients who develop PostHypo with 76% sensitivity and 75% specificity. CONCLUSION:PTH postoperative measurement and its alteration from the preoperative level can be used to identify patients who are at increased risk to develop PostHypo. Copyright
Authors: A Bergenfelz; S Jansson; A Kristoffersson; H Mårtensson; E Reihnér; G Wallin; I Lausen Journal: Langenbecks Arch Surg Date: 2008-07-17 Impact factor: 3.445
Authors: Safina Ali; Changhong Yu; Frank L Palmer; Ian Ganly; Ashok Shaha; Jatin P Shah; Michael W Kattan; Snehal G Patel Journal: Arch Otolaryngol Head Neck Surg Date: 2011-11
Authors: David R Lee; Andrew M Hinson; Eric R Siegel; Susan C Steelman; Donald L Bodenner; Brendan C Stack Journal: Otolaryngol Head Neck Surg Date: 2015-07-24 Impact factor: 3.497
Authors: D Brandon Chapman; Christopher C French; Xiaoyan Leng; J Dale Browne; Joshua D Waltonen; Christopher A Sullivan Journal: Am J Otolaryngol Date: 2011-09-06 Impact factor: 1.808
Authors: Kathrin Nagel; Anne Hendricks; Christina Lenschow; Michael Meir; Stefanie Hahner; Martin Fassnacht; Armin Wiegering; Christoph-Thomas Germer; Nicolas Schlegel Journal: BJS Open Date: 2022-09-02