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Literature DB >> 21493143

IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease.

Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is widely used to dissect molecular mechanisms of MS and to develop new therapeutic strategies. The T helper 17 (Th17) subset of CD4 T cells plays a crucial role in the development of EAE. IL-17, a cytokine produced by Th17 cells, participates in EAE pathogenesis through induction of inflammatory gene expression in target cells. Recent work has shown that Act1, a U-box E3 ubiquitin ligase, is recruited to IL-17 receptor (IL-17R) upon IL-17 stimulation and is required for IL-17-mediated signaling. Here, we review the molecular and cellular mechanisms by which IL-17 and Act1-mediated signaling contribute to EAE.

Entities: Chemical Disease Gene Species

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Year: 2011 PMID： 21493143 PMCID： PMC3329781 DOI： 10.1016/j.it.2011.02.007

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

91 in total

1. Multiple sclerosis: a two-stage disease.

Authors: L Steinman
Journal: Nat Immunol Date: 2001-09 Impact factor: 25.606

2. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma.

Authors: M Kawaguchi; L F Onuchic; X D Li; D M Essayan; J Schroeder; H Q Xiao; M C Liu; G Krishnaswamy; G Germino; S K Huang
Journal: J Immunol Date: 2001-10-15 Impact factor: 5.422

Review 3. Immune function of microglia.

Authors: F Aloisi
Journal: Glia Date: 2001-11 Impact factor: 7.452

4. Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis.

Authors: Jerome R Wujek; Carl Bjartmar; Edward Richer; Richard M Ransohoff; Min Yu; Vincent K Tuohy; Bruce D Trapp
Journal: J Neuropathol Exp Neurol Date: 2002-01 Impact factor: 3.685

5. Act1, an NF-kappa B-activating protein.

Authors: X Li; M Commane; H Nie; X Hua; M Chatterjee-Kishore; D Wald; M Haag; G R Stark
Journal: Proc Natl Acad Sci U S A Date: 2000-09-12 Impact factor: 11.205

6. CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.

Authors: A Leonardi; A Chariot; E Claudio; K Cunningham; U Siebenlist
Journal: Proc Natl Acad Sci U S A Date: 2000-09-12 Impact factor: 11.205

7. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses.

Authors: Susumu Nakae; Yutaka Komiyama; Aya Nambu; Katsuko Sudo; Michiko Iwase; Ikuo Homma; Kenji Sekikawa; Masahide Asano; Yoichiro Iwakura
Journal: Immunity Date: 2002-09 Impact factor: 31.745

8. Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells.

Authors: Youcun Qian; Zhendong Zhao; Zhengfan Jiang; Xiaoxia Li
Journal: Proc Natl Acad Sci U S A Date: 2002-06-27 Impact factor: 11.205

Review 9. Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis.

Authors: Monica J Carson
Journal: Glia Date: 2002-11 Impact factor: 8.073

10. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense.

Authors: P Ye; F H Rodriguez; S Kanaly; K L Stocking; J Schurr; P Schwarzenberger; P Oliver; W Huang; P Zhang; J Zhang; J E Shellito; G J Bagby; S Nelson; K Charrier; J J Peschon; J K Kolls
Journal: J Exp Med Date: 2001-08-20 Impact factor: 14.307

99 in total

10. IL-17 induces expression of vascular cell adhesion molecule through signalling pathway of NF-κB, but not Akt1 and TAK1 in vascular smooth muscle cells.

Authors: H Zhang; J Chen; X Liu; L Awar; A McMickle; F Bai; S Nagarajan; S Yu
Journal: Scand J Immunol Date: 2013-04 Impact factor: 3.487

IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease.

1. Multiple sclerosis: a two-stage disease.

2. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma.

Review 3. Immune function of microglia.

4. Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis.

5. Act1, an NF-kappa B-activating protein.

6. CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.

7. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses.

8. Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells.

Review 9. Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis.

10. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense.

Review 1. Mechanisms regulating regional localization of inflammation during CNS autoimmunity.

2. Cutting edge: TNF receptor-associated factor 4 restricts IL-17-mediated pathology and signaling processes.

Review 3. The potential of mesenchymal stromal cells as a novel cellular therapy for multiple sclerosis.

Review 4. The genomic landscape of human immune-mediated diseases.

5. Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Foxp3 expression.

Review 6. Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K.

7. Glia maturation factor deficiency suppresses 1-methyl-4-phenylpyridinium-induced oxidative stress in astrocytes.

Review 8. The plasticity of human Treg and Th17 cells and its role in autoimmunity.

Review 9. cAMP responsive element modulator: a critical regulator of cytokine production.

10. IL-17 induces expression of vascular cell adhesion molecule through signalling pathway of NF-κB, but not Akt1 and TAK1 in vascular smooth muscle cells.