Literature DB >> 23491535

cAMP responsive element modulator: a critical regulator of cytokine production.

Thomas Rauen1, Christian M Hedrich, Klaus Tenbrock, George C Tsokos.   

Abstract

T lymphocytes from patients with systemic lupus erythematosus (SLE) display a complex array of cellular, molecular, and signaling anomalies, many of which have been attributed to increased expression of the transcriptional regulator cAMP responsive element modulator α (CREMα). Recent evidence indicates that CREMα, in addition to its regulatory functions on gene promoters in T lymphocytes, alters the epigenetic conformation of cytokine genes by interacting with enzymes that control histone methylation and acetylation as well as cytosine-phosphate-guanosine (CpG) DNA methylation. This review summarizes the most recent findings on CREM protein expression in various cell types, in particular its effects on T lymphocyte biology in the context of both health and SLE. We emphasize CREMα as a key molecule that drives autoimmunity.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23491535      PMCID： PMC3891595          DOI： 10.1016/j.molmed.2013.02.001

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  74 in total

1.  cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription.

Authors:  Y Zhou; Z Sun; A R Means; P Sassone-Corsi; K E Bernstein
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

Review 2.  Specialized rules of gene transcription in male germ cells: the CREM paradigm.

Authors:  Lucia Monaco; Noora Kotaja; Giulia Fienga; Kevin Hogeveen; Ullas S Kolthur; Sarah Kimmins; Stefano Brancorsini; Betina Macho; Paolo Sassone-Corsi
Journal:  Int J Androl       Date:  2004-12

3.  Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells.

Authors:  F Sallusto; E Kremmer; B Palermo; A Hoy; P Ponath; S Qin; R Förster; M Lipp; A Lanzavecchia
Journal:  Eur J Immunol       Date:  1999-06       Impact factor: 5.532

4.  Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV.

Authors:  Yuang-Taung Juang; Ying Wang; Elena E Solomou; Yansong Li; Christian Mawrin; Klaus Tenbrock; Vasileios C Kyttaris; George C Tsokos
Journal:  J Clin Invest       Date:  2005-04       Impact factor: 14.808

5.  Stress-induced expression of transcriptional repressor ICER in the adrenal gland.

Authors:  M A Della Fazia; G Servillo; N S Foulkes; P Sassone-Corsi
Journal:  FEBS Lett       Date:  1998-08-28       Impact factor: 4.124

6.  Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes.

Authors:  J Bodor; J F Habener
Journal:  J Biol Chem       Date:  1998-04-17       Impact factor: 5.157

7.  Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic mice.

Authors:  Frank U Müller; Geertje Lewin; Hideo A Baba; Peter Bokník; Larissa Fabritz; Uwe Kirchhefer; Paulus Kirchhof; Karin Loser; Marek Matus; Joachim Neumann; Burkhard Riemann; Wilhelm Schmitz
Journal:  J Biol Chem       Date:  2004-11-29       Impact factor: 5.157

Review 8.  Signal transduction molecules in the rat pineal organ: Ca2+, pCREB, and ICER.

Authors:  H W Korf; C Schomerus; E Maronde; J H Stehle
Journal:  Naturwissenschaften       Date:  1996-12

9.  Inducible cAMP early repressor can modulate tyrosine hydroxylase gene expression after stimulation of cAMP synthesis.

Authors:  C Tinti; B Conti; J F Cubells; K S Kim; H Baker; T H Joh
Journal:  J Biol Chem       Date:  1996-10-11       Impact factor: 5.157

Review 10.  Rhythmic transcription: the molecular basis of circadian melatonin synthesis.

Authors:  N S Foulkes; D Whitmore; P Sassone-Corsi
Journal:  Biol Cell       Date:  1997-11       Impact factor: 4.458
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  30 in total

1.  EWSR1 Fusions With CREB Family Transcription Factors Define a Novel Myxoid Mesenchymal Tumor With Predilection for Intracranial Location.

Authors:  Yu-Chien Kao; Yun-Shao Sung; Lei Zhang; Chun-Liang Chen; Sumathi Vaiyapuri; Marc K Rosenblum; Cristina R Antonescu
Journal:  Am J Surg Pathol       Date:  2017-04       Impact factor: 6.394

2.  Interleukin-2 treatment reverses effects of cAMP-responsive element modulator α-over-expressing T cells in autoimmune-prone mice.

Authors:  K Ohl; A Wiener; A Schippers; N Wagner; K Tenbrock
Journal:  Clin Exp Immunol       Date:  2015-05-14       Impact factor: 4.330

Review 3.  T cells and autoimmune kidney disease.

Authors:  Abel Suárez-Fueyo; Sean J Bradley; David Klatzmann; George C Tsokos
Journal:  Nat Rev Nephrol       Date:  2017-03-13       Impact factor: 28.314

Review 4.  DNA methylation in systemic lupus erythematosus.

Authors:  Christian M Hedrich; Katrin Mäbert; Thomas Rauen; George C Tsokos
Journal:  Epigenomics       Date:  2016-11-25       Impact factor: 4.778

5.  Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling.

Authors:  Christian M Hedrich; Thomas Rauen; Sokratis A Apostolidis; Alexandros P Grammatikos; Noe Rodriguez Rodriguez; Christina Ioannidis; Vasileios C Kyttaris; Jose C Crispin; George C Tsokos
Journal:  Proc Natl Acad Sci U S A       Date:  2014-09-03       Impact factor: 11.205

Review 6.  Epigenetics and Systemic Lupus Erythematosus: Unmet Needs.

Authors:  Pier Luigi Meroni; Alessandra Emiliana Penatti
Journal:  Clin Rev Allergy Immunol       Date:  2016-06       Impact factor: 8.667

7.  cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease.

Authors:  Christian M Hedrich; Thomas Rauen; Jose C Crispin; Tomohiro Koga; Christina Ioannidis; Melissa Zajdel; Vasileios C Kyttaris; George C Tsokos
Journal:  J Biol Chem       Date:  2013-09-18       Impact factor: 5.157

8.  cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.

Authors:  Christian M Hedrich; José C Crispín; Thomas Rauen; Christina Ioannidis; Tomohiro Koga; Noe Rodriguez Rodriguez; Sokratis A Apostolidis; Vasileios C Kyttaris; George C Tsokos
Journal:  J Biol Chem       Date:  2013-12-02       Impact factor: 5.157

9.  cAMP Response Element Modulator α Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus.

Authors:  Sigrun R Hofmann; Katrin Mäbert; Franz Kapplusch; Susanne Russ; Sarah Northey; Michael W Beresford; George C Tsokos; Christian M Hedrich
Journal:  J Immunol       Date:  2019-10-25       Impact factor: 5.422

10.  Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4+ T Cells in Psoriasis.

Authors:  Sigrun R Hofmann; Emil Carlsson; Franz Kapplusch; Ana L Carvalho; Triantafillos Liloglou; Felix Schulze; Susanne Abraham; Sarah Northey; Susanne Russ; Anna E A Surace; Nobuya Yoshida; George C Tsokos; Christian M Hedrich
Journal:  J Immunol       Date:  2021-06-16       Impact factor: 5.422
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