Literature DB >> 21492232

The presence of Epstein-Barr virus (EBV) in diffuse large B-cell lymphomas (DLBCLs) in Turkey: special emphasis on 'EBV-positive DLBCL of the elderly'.

Aysegul Uner1, Nalan Akyurek, Arzu Saglam, Samir Abdullazade, Nuket Uzum, Sevgen Onder, Ibrahim Barista, Mustafa Benekli.   

Abstract

Accumulated evidence has shown the importance of Epstein-Barr virus in the pathogenesis of various lymphomas. This study aimed to determine the prevalence of Epstein-Barr virus expression and its effect on survival amongst diffuse large B-cell lymphoma (DLBCL) cases from two large tertiary care centres in Turkey with a particular interest in identifying cases of 'Epstein-Barr virus-positive DLBCL of the elderly'. Diffuse large B-cell lymphoma cases diagnosed between 1999 and 2009 were retrieved and 340 cases were used to construct tissue microarrays. The presence of Epstein-Barr virus small ribonucleic acids was examined by in situ hybridization using Epstein-Barr virus (EBV)-encoded small RNA (EBER) oligonucleotides. A total of 18 cases (5.3%) showed Epstein-Barr virus expression. Twelve cases were classified as Epstein-Barr virus-positive DLBCL of the elderly. Epstein-Barr virus-positive DLBCL cases showed a significantly inferior overall survival as compared with Epstein-Barr virus-negative cases (p < 0.001). In our study group Epstein-Barr virus expression is not prevalent in DLBCLs. Epstein-Barr virus-positive DLBCL of the elderly is also rare in the Turkish population. The presence of Epstein-Barr virus, however, is associated with poor prognosis.
© 2011 The Authors. APMIS © 2011 APMIS.

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Year:  2011        PMID： 21492232     DOI： 10.1111/j.1600-0463.2011.02736.x

Source DB:  PubMed          Journal:  APMIS        ISSN： 0903-4641            Impact factor:   3.205


  11 in total

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Journal:  Am J Blood Res       Date:  2011-09-09

2.  Epstein-Barr Viral Load is Associated to Response in AIDS-Related Lymphomas.

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Journal:  Indian J Hematol Blood Transfus       Date:  2014-02-08       Impact factor: 0.900

3.  Prevalence and clinical implications of epstein-barr virus infection in de novo diffuse large B-cell lymphoma in Western countries.

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Journal:  Clin Cancer Res       Date:  2014-02-28       Impact factor: 12.531

4.  Primary CNS lymphoma in scleroderma: a case series.

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Review 5.  EBV-positive diffuse large B-cell lymphoma of the elderly.

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Journal:  Blood       Date:  2013-05-06       Impact factor: 22.113

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Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2015-06-18       Impact factor: 4.291

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Journal:  Sci Rep       Date:  2020-07-23       Impact factor: 4.379

8.  Clinical outcome of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly in the rituximab era.

Authors:  Ai Sato; Naoya Nakamura; Minoru Kojima; Ken Ohmachi; Joaquim Carreras; Yara Yukie Kikuti; Hiroki Numata; Daisuke Ohgiya; Kei Tazume; Jun Amaki; Makiko Moriuchi; Mitsuki Miyamoto; Yasuyuki Aoyama; Hidetsugu Kawai; Akifumi Ichiki; Ryujiro Hara; Hiroshi Kawada; Yoshiaki Ogawa; Kiyoshi Ando
Journal:  Cancer Sci       Date:  2014-09-08       Impact factor: 6.716

9.  Cytotoxic response against Epstein Barr virus coexists with diffuse large B-cell lymphoma tolerogenic microenvironment: clinical features and survival impact.

Authors:  Melina Cohen; Aldana G Vistarop; Fuad Huaman; Marina Narbaitz; Fernanda Metrebian; Elena De Matteo; María V Preciado; Paola A Chabay
Journal:  Sci Rep       Date:  2017-09-07       Impact factor: 4.379

10.  Specific Soft-Tissue Invasion and LMP1 Expression Are Potential Indicators of Extranodal NK/T Cell Lymphoma, Nasal Type.

Authors:  Min Jiang; Haoyue Lu; Chao Lu; Xingdong Geng; Yingjun Jia; Peng Wang; Wei Qian; Hao Huang; Xiuhong Shan
Journal:  Med Sci Monit       Date:  2018-10-25
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