AIM: Obesity is a global, growing public-health problem. The detrimental health consequences of obesity are significant and include co-morbidities such as diabetes, coronary heart disease, and some types of cancer. To date, findings relating the A allele of the FTO variant rs9939609 to increased energy intake and risk for obesity have been fairly consistent across multiple populations. However, it is not known whether that relationship is also present in American Indian (AI) populations. The purpose of this study was to examine the minor allele frequency of the FTO variant rs9939609 and its associations with birth weight, weight for length (WFL) Z score, and amount of formula intake in AI infants. DESIGN: A cross-sectional exploratory descriptive design was applied with a sample of 49 AI mother-infant dyads. RESULTS: Mothers with an A allele had higher prepregnancy body mass index than those without an A allele, though difference was not statistically significant (p=0.08). Infants with an A allele tended to have higher birth weights, WFL Z score at age 14 to 20 weeks, and 24-h formula consumption compared with infants without an A-allele, though those differences were not statistically significant (p>0.05). Neither maternal nor infant A alleles were statistically significantly associated with birth weight, WFL Z score, and amount of formula intake in AI infants (p>0.05). CONCLUSIONS: The findings do not confirm the association of the A allele of the FTO variant rs9939609 with birth weight, amount of formula intake, and WFL Z score in AI infants.
AIM: Obesity is a global, growing public-health problem. The detrimental health consequences of obesity are significant and include co-morbidities such as diabetes, coronary heart disease, and some types of cancer. To date, findings relating the A allele of the FTO variant rs9939609 to increased energy intake and risk for obesity have been fairly consistent across multiple populations. However, it is not known whether that relationship is also present in American Indian (AI) populations. The purpose of this study was to examine the minor allele frequency of the FTO variant rs9939609 and its associations with birth weight, weight for length (WFL) Z score, and amount of formula intake in AI infants. DESIGN: A cross-sectional exploratory descriptive design was applied with a sample of 49 AI mother-infant dyads. RESULTS: Mothers with an A allele had higher prepregnancy body mass index than those without an A allele, though difference was not statistically significant (p=0.08). Infants with an A allele tended to have higher birth weights, WFL Z score at age 14 to 20 weeks, and 24-h formula consumption compared with infants without an A-allele, though those differences were not statistically significant (p>0.05). Neither maternal nor infant A alleles were statistically significantly associated with birth weight, WFL Z score, and amount of formula intake in AI infants (p>0.05). CONCLUSIONS: The findings do not confirm the association of the A allele of the FTO variant rs9939609 with birth weight, amount of formula intake, and WFL Z score in AI infants.
Authors: Steven C Hunt; Steven Stone; Yuanpei Xin; Christina A Scherer; Charles L Magness; Shawn P Iadonato; Paul N Hopkins; Ted D Adams Journal: Obesity (Silver Spring) Date: 2008-01-24 Impact factor: 5.002
Authors: T Jess; E Zimmermann; S I I Kring; T Berentzen; C Holst; S Toubro; A Astrup; T Hansen; O Pedersen; T I A Sørensen Journal: Int J Obes (Lond) Date: 2008-07-29 Impact factor: 5.095
Authors: Timothy M Frayling; Nicholas J Timpson; Michael N Weedon; Eleftheria Zeggini; Rachel M Freathy; Cecilia M Lindgren; John R B Perry; Katherine S Elliott; Hana Lango; Nigel W Rayner; Beverley Shields; Lorna W Harries; Jeffrey C Barrett; Sian Ellard; Christopher J Groves; Bridget Knight; Ann-Marie Patch; Andrew R Ness; Shah Ebrahim; Debbie A Lawlor; Susan M Ring; Yoav Ben-Shlomo; Marjo-Riitta Jarvelin; Ulla Sovio; Amanda J Bennett; David Melzer; Luigi Ferrucci; Ruth J F Loos; Inês Barroso; Nicholas J Wareham; Fredrik Karpe; Katharine R Owen; Lon R Cardon; Mark Walker; Graham A Hitman; Colin N A Palmer; Alex S F Doney; Andrew D Morris; George Davey Smith; Andrew T Hattersley; Mark I McCarthy Journal: Science Date: 2007-04-12 Impact factor: 47.728
Authors: Christian Dina; David Meyre; Sophie Gallina; Emmanuelle Durand; Antje Körner; Peter Jacobson; Lena M S Carlsson; Wieland Kiess; Vincent Vatin; Cecile Lecoeur; Jérome Delplanque; Emmanuel Vaillant; François Pattou; Juan Ruiz; Jacques Weill; Claire Levy-Marchal; Fritz Horber; Natascha Potoczna; Serge Hercberg; Catherine Le Stunff; Pierre Bougnères; Peter Kovacs; Michel Marre; Beverley Balkau; Stéphane Cauchi; Jean-Claude Chèvre; Philippe Froguel Journal: Nat Genet Date: 2007-05-13 Impact factor: 38.330
Authors: Jane Wardle; Susan Carnell; Claire M A Haworth; I Sadaf Farooqi; Stephen O'Rahilly; Robert Plomin Journal: J Clin Endocrinol Metab Date: 2008-06-26 Impact factor: 5.958
Authors: Anke Hinney; Thuy Trang Nguyen; André Scherag; Susann Friedel; Günter Brönner; Timo Dirk Müller; Harald Grallert; Thomas Illig; H-Erich Wichmann; Winfried Rief; Helmut Schäfer; Johannes Hebebrand Journal: PLoS One Date: 2007-12-26 Impact factor: 3.240
Authors: Thomas Gerken; Christophe A Girard; Yi-Chun Loraine Tung; Celia J Webby; Vladimir Saudek; Kirsty S Hewitson; Giles S H Yeo; Michael A McDonough; Sharon Cunliffe; Luke A McNeill; Juris Galvanovskis; Patrik Rorsman; Peter Robins; Xavier Prieur; Anthony P Coll; Marcella Ma; Zorica Jovanovic; I Sadaf Farooqi; Barbara Sedgwick; Inês Barroso; Tomas Lindahl; Chris P Ponting; Frances M Ashcroft; Stephen O'Rahilly; Christopher J Schofield Journal: Science Date: 2007-11-08 Impact factor: 47.728