OBJECTIVE AND DESIGN: We investigated the impact of the fatness-related FTO rs9939609 A-allele on cross-sectional and longitudinal measures of body mass index (BMI), height and lean body mass (LBM) in a unique cohort representing a broad range of BMI. SUBJECTS AND MEASUREMENTS: A random sample of all men attending the Danish draft boards during 1943-1977 plus all men with a BMI>or=31.0 kg/m(2) (assuring representation of the right end of the distribution) was taken. Anthropometric measures were available at up to eight points in time from birth to adulthood in 1629 genotyped men. The odds ratio (OR) for being a carrier of FTO rs9939609 according to (1) one unit alteration in z-scores for BMI, height and LBM at given ages and (2) longitudinal changes in BMI and height z-scores were assessed by logistic regression. RESULTS: Except at birth, the AA genotype was associated with increased BMI z-scores at all point during the monitored lifespan, starting at the age of 7 years. This effect remained stable until early adulthood, where further weight gain occurred. The AA genotype was also--mainly through the effect on fatness--associated with accelerated linear growth in childhood (age 7 years; OR, 1.36; 95% confidence interval (CI), 1.06-1.74) and increased LBM in adulthood (OR, 1.24; 95% CI, 1.14-1.35). CONCLUSION: Fatness induced by FTO rs9939609 in early childhood is sustained until early adulthood, where further weight gain may occur. FTO rs9939609 may, however, also be associated with linear growth and LBM mainly through the effect on fat mass.
OBJECTIVE AND DESIGN: We investigated the impact of the fatness-related FTOrs9939609 A-allele on cross-sectional and longitudinal measures of body mass index (BMI), height and lean body mass (LBM) in a unique cohort representing a broad range of BMI. SUBJECTS AND MEASUREMENTS: A random sample of all men attending the Danish draft boards during 1943-1977 plus all men with a BMI>or=31.0 kg/m(2) (assuring representation of the right end of the distribution) was taken. Anthropometric measures were available at up to eight points in time from birth to adulthood in 1629 genotyped men. The odds ratio (OR) for being a carrier of FTOrs9939609 according to (1) one unit alteration in z-scores for BMI, height and LBM at given ages and (2) longitudinal changes in BMI and height z-scores were assessed by logistic regression. RESULTS: Except at birth, the AA genotype was associated with increased BMI z-scores at all point during the monitored lifespan, starting at the age of 7 years. This effect remained stable until early adulthood, where further weight gain occurred. The AA genotype was also--mainly through the effect on fatness--associated with accelerated linear growth in childhood (age 7 years; OR, 1.36; 95% confidence interval (CI), 1.06-1.74) and increased LBM in adulthood (OR, 1.24; 95% CI, 1.14-1.35). CONCLUSION: Fatness induced by FTOrs9939609 in early childhood is sustained until early adulthood, where further weight gain may occur. FTOrs9939609 may, however, also be associated with linear growth and LBM mainly through the effect on fat mass.
Authors: Rebecca Hardy; Andrew K Wills; Andrew Wong; Cathy E Elks; Nicholas J Wareham; Ruth J F Loos; Diana Kuh; Ken K Ong Journal: Hum Mol Genet Date: 2009-10-31 Impact factor: 6.150
Authors: Branwen J Hennig; Anthony J Fulford; Giorgio Sirugo; Pura Rayco-Solon; Andrew T Hattersley; Timothy M Frayling; Andrew M Prentice Journal: BMC Med Genet Date: 2009-03-05 Impact factor: 2.103
Authors: Janine F Felix; Jonathan P Bradfield; Claire Monnereau; Ralf J P van der Valk; Evie Stergiakouli; Alessandra Chesi; Romy Gaillard; Bjarke Feenstra; Elisabeth Thiering; Eskil Kreiner-Møller; Anubha Mahajan; Niina Pitkänen; Raimo Joro; Alana Cavadino; Ville Huikari; Steve Franks; Maria M Groen-Blokhuis; Diana L Cousminer; Julie A Marsh; Terho Lehtimäki; John A Curtin; Jesus Vioque; Tarunveer S Ahluwalia; Ronny Myhre; Thomas S Price; Natalia Vilor-Tejedor; Loïc Yengo; Niels Grarup; Ioanna Ntalla; Wei Ang; Mustafa Atalay; Hans Bisgaard; Alexandra I Blakemore; Amelie Bonnefond; Lisbeth Carstensen; Johan Eriksson; Claudia Flexeder; Lude Franke; Frank Geller; Mandy Geserick; Anna-Liisa Hartikainen; Claire M A Haworth; Joel N Hirschhorn; Albert Hofman; Jens-Christian Holm; Momoko Horikoshi; Jouke Jan Hottenga; Jinyan Huang; Haja N Kadarmideen; Mika Kähönen; Wieland Kiess; Hanna-Maaria Lakka; Timo A Lakka; Alexandra M Lewin; Liming Liang; Leo-Pekka Lyytikäinen; Baoshan Ma; Per Magnus; Shana E McCormack; George McMahon; Frank D Mentch; Christel M Middeldorp; Clare S Murray; Katja Pahkala; Tune H Pers; Roland Pfäffle; Dirkje S Postma; Christine Power; Angela Simpson; Verena Sengpiel; Carla M T Tiesler; Maties Torrent; André G Uitterlinden; Joyce B van Meurs; Rebecca Vinding; Johannes Waage; Jane Wardle; Eleftheria Zeggini; Babette S Zemel; George V Dedoussis; Oluf Pedersen; Philippe Froguel; Jordi Sunyer; Robert Plomin; Bo Jacobsson; Torben Hansen; Juan R Gonzalez; Adnan Custovic; Olli T Raitakari; Craig E Pennell; Elisabeth Widén; Dorret I Boomsma; Gerard H Koppelman; Sylvain Sebert; Marjo-Riitta Järvelin; Elina Hyppönen; Mark I McCarthy; Virpi Lindi; Niinikoski Harri; Antje Körner; Klaus Bønnelykke; Joachim Heinrich; Mads Melbye; Fernando Rivadeneira; Hakon Hakonarson; Susan M Ring; George Davey Smith; Thorkild I A Sørensen; Nicholas J Timpson; Struan F A Grant; Vincent W V Jaddoe Journal: Hum Mol Genet Date: 2015-11-24 Impact factor: 6.150