Literature DB >> 21490603

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

Philip M Reaper1, Matthew R Griffiths, Joanna M Long, Jean-Damien Charrier, Somhairle Maccormick, Peter A Charlton, Julian M C Golec, John R Pollard.   

Abstract

Here we report a comprehensive biological characterization of a potent and selective small-molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound synthetic lethal interaction between ATR and the ATM-p53 tumor suppressor pathway in cells treated with DNA-damaging agents and establish ATR inhibition as a way to transform the outcome for patients with cancer treated with ionizing radiation or genotoxic drugs.

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Year:  2011        PMID： 21490603     DOI： 10.1038/nchembio.573

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  25 in total

1.  The ATM/p53 pathway is commonly targeted for inactivation in squamous cell carcinoma of the head and neck (SCCHN) by multiple molecular mechanisms.

Authors:  Jennifer Bolt; Quynh N Vo; Wan-Ju Kim; Andrew J McWhorter; Jessica Thomson; Michael E Hagensee; Paul Friedlander; Kevin D Brown; Jill Gilbert
Journal:  Oral Oncol       Date:  2005-08-31       Impact factor: 5.337

2.  Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer.

Authors:  Trudy G Oliver; Kim L Mercer; Leanne C Sayles; James R Burke; Diana Mendus; Katherine S Lovejoy; Mei-Hsin Cheng; Aravind Subramanian; David Mu; Scott Powers; Denise Crowley; Roderick T Bronson; Charles A Whittaker; Arjun Bhutkar; Stephen J Lippard; Todd Golub; Juergen Thomale; Tyler Jacks; E Alejandro Sweet-Cordero
Journal:  Genes Dev       Date:  2010-04-15       Impact factor: 11.361

3.  ATR and ATRIP: partners in checkpoint signaling.

Authors:  D Cortez; S Guntuku; J Qin; S J Elledge
Journal:  Science       Date:  2001-11-23       Impact factor: 47.728

4.  DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy.

Authors:  Ken A Olaussen; Ariane Dunant; Pierre Fouret; Elisabeth Brambilla; Fabrice André; Vincent Haddad; Estelle Taranchon; Martin Filipits; Robert Pirker; Helmut H Popper; Rolf Stahel; Laure Sabatier; Jean-Pierre Pignon; Thomas Tursz; Thierry Le Chevalier; Jean-Charles Soria
Journal:  N Engl J Med       Date:  2006-09-07       Impact factor: 91.245

5.  Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

Authors:  Haruyuki Takemura; V Ashutosh Rao; Olivier Sordet; Takahisa Furuta; Ze-Hong Miao; Linghua Meng; Hongliang Zhang; Yves Pommier
Journal:  J Biol Chem       Date:  2006-08-10       Impact factor: 5.157

6.  Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.

Authors:  I M Ward; J Chen
Journal:  J Biol Chem       Date:  2001-10-22       Impact factor: 5.157

7.  DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.

Authors:  Christopher J Bakkenist; Michael B Kastan
Journal:  Nature       Date:  2003-01-30       Impact factor: 49.962

Review 8.  How do real tumors become resistant to cisplatin?

Authors:  Piet Borst; Sven Rottenberg; Jos Jonkers
Journal:  Cell Cycle       Date:  2008-03-17       Impact factor: 4.534

9.  Patterns of somatic mutation in human cancer genomes.

Authors:  Christopher Greenman; Philip Stephens; Raffaella Smith; Gillian L Dalgliesh; Christopher Hunter; Graham Bignell; Helen Davies; Jon Teague; Adam Butler; Claire Stevens; Sarah Edkins; Sarah O'Meara; Imre Vastrik; Esther E Schmidt; Tim Avis; Syd Barthorpe; Gurpreet Bhamra; Gemma Buck; Bhudipa Choudhury; Jody Clements; Jennifer Cole; Ed Dicks; Simon Forbes; Kris Gray; Kelly Halliday; Rachel Harrison; Katy Hills; Jon Hinton; Andy Jenkinson; David Jones; Andy Menzies; Tatiana Mironenko; Janet Perry; Keiran Raine; Dave Richardson; Rebecca Shepherd; Alexandra Small; Calli Tofts; Jennifer Varian; Tony Webb; Sofie West; Sara Widaa; Andy Yates; Daniel P Cahill; David N Louis; Peter Goldstraw; Andrew G Nicholson; Francis Brasseur; Leendert Looijenga; Barbara L Weber; Yoke-Eng Chiew; Anna DeFazio; Mel F Greaves; Anthony R Green; Peter Campbell; Ewan Birney; Douglas F Easton; Georgia Chenevix-Trench; Min-Han Tan; Sok Kean Khoo; Bin Tean Teh; Siu Tsan Yuen; Suet Yi Leung; Richard Wooster; P Andrew Futreal; Michael R Stratton
Journal:  Nature       Date:  2007-03-08       Impact factor: 49.962

Review 10.  Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin.

Authors:  Andrea Kinner; Wenqi Wu; Christian Staudt; George Iliakis
Journal:  Nucleic Acids Res       Date:  2008-09-04       Impact factor: 16.971
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  277 in total

1.  Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro.

Authors:  Anand G Patel; Silvana B De Lorenzo; Karen S Flatten; Guy G Poirier; Scott H Kaufmann
Journal:  Clin Cancer Res       Date:  2012-01-30       Impact factor: 12.531

2.  Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.

Authors:  Susan E Scanlon; Peter M Glazer
Journal:  Mol Cancer Res       Date:  2014-03-31       Impact factor: 5.852

3.  Coupling of Homologous Recombination and the Checkpoint by ATR.

Authors:  Rémi Buisson; Joshi Niraj; Amélie Rodrigue; Chu Kwen Ho; Johannes Kreuzer; Tzeh Keong Foo; Emilie J-L Hardy; Graham Dellaire; Wilhelm Haas; Bing Xia; Jean-Yves Masson; Lee Zou
Journal:  Mol Cell       Date:  2017-01-12       Impact factor: 17.970

Review 4.  Structure and bioactivity of colibactin.

Authors:  Kevin M Wernke; Mengzhao Xue; Alina Tirla; Chung Sub Kim; Jason M Crawford; Seth B Herzon
Journal:  Bioorg Med Chem Lett       Date:  2020-05-23       Impact factor: 2.823

5.  FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.

Authors:  Jo Ishizawa; Eiji Sugihara; Shinji Kuninaka; Kaoru Mogushi; Kensuke Kojima; Christopher B Benton; Ran Zhao; Dhruv Chachad; Norisato Hashimoto; Rodrigo O Jacamo; Yihua Qiu; Suk Young Yoo; Shinichiro Okamoto; Michael Andreeff; Steven M Kornblau; Hideyuki Saya
Journal:  Blood       Date:  2017-01-31       Impact factor: 22.113

6.  HUS1 regulates in vivo responses to genotoxic chemotherapies.

Authors:  G Balmus; P X Lim; A Oswald; K R Hume; A Cassano; J Pierre; A Hill; W Huang; A August; T Stokol; T Southard; R S Weiss
Journal:  Oncogene       Date:  2015-04-27       Impact factor: 9.867

7.  Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.

Authors:  Yuxia Cui; Stela S Palii; Cynthia L Innes; Richard S Paules
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

8.  PCNA-Ub polyubiquitination inhibits cell proliferation and induces cell-cycle checkpoints.

Authors:  Zhoushuai Qin; Zhiqiang Bai; Ying Sun; Xiaohong Niu; Wei Xiao
Journal:  Cell Cycle       Date:  2016-10-18       Impact factor: 4.534

9.  Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis.

Authors:  Libor Macurek; Jan Benada; Erik Müllers; Vincentius A Halim; Kateřina Krejčíková; Kamila Burdová; Sona Pecháčková; Zdeněk Hodný; Arne Lindqvist; René H Medema; Jiri Bartek
Journal:  Cell Cycle       Date:  2012-01-15       Impact factor: 4.534

Review 10.  Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer.

Authors:  Shih-Hung Yang; Ting-Chun Kuo; Hsu Wu; Jhe-Cyuan Guo; Chiun Hsu; Chih-Hung Hsu; Yu-Wen Tien; Kun-Huei Yeh; Ann-Lii Cheng; Sung-Hsin Kuo
Journal:  World J Gastroenterol       Date:  2016-08-28       Impact factor: 5.742
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