Literature DB >> 21490099

Partial functional complementation between human and mouse cytomegalovirus chemokine receptor homologues.

Helen E Farrell1, Alexander M Abraham, Rhonda D Cardin, Alexander H Sparre-Ulrich, Mette M Rosenkilde, Katja Spiess, Tine H Jensen, Thomas N Kledal, Nicholas Davis-Poynter.   

Abstract

The human cytomegalovirus (CMV) proteins US28 and UL33 are homologous to chemokine receptors (CKRs). Knockout of the mouse CMV M33 protein (UL33 homologue) results in substantial attenuation of salivary gland infection/replication and reduced efficiency of reactivation from tissue explants. M33-mediated G protein-coupled signaling is critical for the salivary gland phenotype. In this report, we demonstrate that US28 and (to a lesser degree) UL33 restore reactivation from tissue explants and partially restore replication in salivary glands (compared to a signaling-deficient M33 mutant). These studies provide a novel small animal model for evaluation of therapies targeting the human CMV CKRs.

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Year:  2011        PMID： 21490099      PMCID： PMC3126309          DOI： 10.1128/JVI.02113-10

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

1.  Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28.

Authors:  Janneke W Hulshof; Henry F Vischer; Mark H P Verheij; Silvina A Fratantoni; Martine J Smit; Iwan J P de Esch; Rob Leurs
Journal:  Bioorg Med Chem       Date:  2006-07-14       Impact factor: 3.641

2.  Coevolution of the mammalian chemokines and their receptors.

Authors:  A L Hughes; M Yeager
Journal:  Immunogenetics       Date:  1999-02       Impact factor: 2.846

3.  G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.

Authors:  William E Miller; Daniel A Houtz; Christopher D Nelson; P E Kolattukudy; Robert J Lefkowitz
Journal:  J Biol Chem       Date:  2003-03-31       Impact factor: 5.157

4.  Identification and characterization of a G protein-coupled receptor homolog encoded by murine cytomegalovirus.

Authors:  N J Davis-Poynter; D M Lynch; H Vally; G R Shellam; W D Rawlinson; B G Barrell; H E Farrell
Journal:  J Virol       Date:  1997-02       Impact factor: 5.103

5.  Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74.

Authors:  Katherine A McLean; Peter J Holst; Lene Martini; Thue W Schwartz; Mette M Rosenkilde
Journal:  Virology       Date:  2004-08-01       Impact factor: 3.616

6.  Activation of intracellular signaling pathways by the murine cytomegalovirus G protein-coupled receptor M33 occurs via PLC-{beta}/PKC-dependent and -independent mechanisms.

Authors:  Joseph D Sherrill; Melissa P Stropes; Olivia D Schneider; Diana E Koch; Fabiola M Bittencourt; Jeanette L C Miller; William E Miller
Journal:  J Virol       Date:  2009-06-03       Impact factor: 5.103

7.  Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus.

Authors:  C A Stoddart; R D Cardin; J M Boname; W C Manning; G B Abenes; E S Mocarski
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103

8.  The M33 chemokine receptor homolog of murine cytomegalovirus exhibits a differential tissue-specific role during in vivo replication and latency.

Authors:  Rhonda D Cardin; Gregory C Schaefer; Janelle R Allen; Nicholas J Davis-Poynter; Helen E Farrell
Journal:  J Virol       Date:  2009-05-13       Impact factor: 5.103

Review 9.  Virally encoded G protein-coupled receptors: targets for potentially innovative anti-viral drug development.

Authors:  M J Smit; C Vink; D Verzijl; P Casarosa; C A Bruggeman; R Leurs
Journal:  Curr Drug Targets       Date:  2003-07       Impact factor: 3.465

10.  Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo.

Authors:  Ruth Case; Emma Sharp; Tau Benned-Jensen; Mette M Rosenkilde; Nicholas Davis-Poynter; Helen E Farrell
Journal:  J Virol       Date:  2007-12-05       Impact factor: 5.103
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  24 in total

1.  Development of a Primary Human Cell Model for the Study of Human Cytomegalovirus Replication and Spread within Salivary Epithelium.

Authors:  Kristen M Morrison; Matthew J Beucler; Emily O Campbell; Margaret A White; Rachel E Boody; Keith C Wilson; William E Miller
Journal:  J Virol       Date:  2019-01-17       Impact factor: 5.103

2.  Flagellin, a TLR5 agonist, reduces graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients while enhancing antiviral immunity.

Authors:  Mohammad S Hossain; David L Jaye; Brian P Pollack; Alton B Farris; Malefa L Tselanyane; Ebenezer David; John D Roback; Andrew T Gewirtz; Edmund K Waller
Journal:  J Immunol       Date:  2011-10-17       Impact factor: 5.422

3.  Methods for Studying the Function of Cytomegalovirus GPCRs.

Authors:  Christine M O'Connor; William E Miller
Journal:  Methods Mol Biol       Date:  2021

4.  Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model.

Authors:  Helen E Farrell; Alexander M Abraham; Rhonda D Cardin; Ann-Sofie Mølleskov-Jensen; Mette M Rosenkilde; Nicholas Davis-Poynter
Journal:  J Virol       Date:  2013-01-23       Impact factor: 5.103

5.  The HCMV US28 vGPCR induces potent Gαq/PLC-β signaling in monocytes leading to increased adhesion to endothelial cells.

Authors:  Shu-En Wu; William E Miller
Journal:  Virology       Date:  2016-08-04       Impact factor: 3.616

Review 6.  Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?

Authors:  Henry F Vischer; Marco Siderius; Rob Leurs; Martine J Smit
Journal:  Nat Rev Drug Discov       Date:  2014-01-21       Impact factor: 84.694

7.  The human cytomegalovirus US27 gene product enhances cell proliferation and alters cellular gene expression.

Authors:  Angela P Lares; Carolyn C Tu; Juliet V Spencer
Journal:  Virus Res       Date:  2013-07-11       Impact factor: 3.303

8.  The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties.

Authors:  Jeffrey R van Senten; Maarten P Bebelman; Tian Shu Fan; Raimond Heukers; Nick D Bergkamp; Puck van Gasselt; Ellen V Langemeijer; Erik Slinger; Tonny Lagerweij; Afsar Rahbar; Marijke Stigter-van Walsum; David Maussang; Rob Leurs; René J P Musters; Guus A M S van Dongen; Cecilia Söderberg-Nauclér; Thomas Würdinger; Marco Siderius; Martine J Smit
Journal:  J Biol Chem       Date:  2019-09-13       Impact factor: 5.157

Review 9.  Emerging roles of cytomegalovirus-encoded G protein-coupled receptors during lytic and latent infection.

Authors:  Theresa Frank; Ina Niemann; Anna Reichel; Thomas Stamminger
Journal:  Med Microbiol Immunol       Date:  2019-03-21       Impact factor: 3.402

10.  The M33 G protein-coupled receptor encoded by murine cytomegalovirus is dispensable for hematogenous dissemination but is required for growth within the salivary gland.

Authors:  Fabiola M Bittencourt; Shu-En Wu; James P Bridges; William E Miller
Journal:  J Virol       Date:  2014-08-06       Impact factor: 5.103
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