Literature DB >> 24445563

Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?

Henry F Vischer1, Marco Siderius1, Rob Leurs1, Martine J Smit1.   

Abstract

Herpesviruses encode membrane-associated G protein-coupled receptors (GPCRs) in their viral genomes that are structurally similar to chemokine receptors. These GPCRs hijack GPCR-mediated cellular signalling networks of the host for survival, replication and pathogenesis. In particular the herpesvirus-encoded chemokine receptors ORF74, BILF1 and US28, which are present at inflammatory sites and tumour cells, provide important virus-specific targets for directed therapies. Given the high druggability of GPCRs in general, these viral GPCRs can be considered promising antiviral drug targets.

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Year:  2014        PMID： 24445563     DOI： 10.1038/nrd4189

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  182 in total

Review 1.  Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity.

Authors:  Martine J Smit; Henry F Vischer; Remko A Bakker; Aldo Jongejan; Henk Timmerman; Leonardo Pardo; Rob Leurs
Journal:  Annu Rev Pharmacol Toxicol       Date:  2007       Impact factor: 13.820

2.  Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.

Authors:  Qi Ma; Lucas E Cavallin; Bin Yan; Shoukang Zhu; Elda Margarita Duran; Huili Wang; Laura P Hale; Chunming Dong; Ethel Cesarman; Enrique A Mesri; Pascal J Goldschmidt-Clermont
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-08       Impact factor: 11.205

3.  Characterization of the rhesus cytomegalovirus US28 locus.

Authors:  M E T Penfold; T L Schmidt; D J Dairaghi; P A Barry; T J Schall
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

4.  Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor.

Authors:  Paola Casarosa; Wiro M Menge; Rosalba Minisini; Claas Otto; Jane van Heteren; Aldo Jongejan; Henk Timmerman; Barbara Moepps; Frank Kirchhoff; Thomas Mertens; Martine J Smit; Rob Leurs
Journal:  J Biol Chem       Date:  2002-11-26       Impact factor: 5.157

5.  Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells.

Authors:  K A Staskus; W Zhong; K Gebhard; B Herndier; H Wang; R Renne; J Beneke; J Pudney; D J Anderson; D Ganem; A T Haase
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

6.  The Epstein-Barr virus BILF1 gene encodes a G protein-coupled receptor that inhibits phosphorylation of RNA-dependent protein kinase.

Authors:  Patrick S Beisser; Dennis Verzijl; Yvonne K Gruijthuijsen; Erik Beuken; Martine J Smit; Rob Leurs; Cathrien A Bruggeman; Cornelis Vink
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

7.  Intracellular signaling by the chemokine receptor US28 during human cytomegalovirus infection.

Authors:  M A Billstrom; G L Johnson; N J Avdi; G S Worthen
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

8.  RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA.

Authors:  Yuying Liang; Don Ganem
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

9.  Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells.

Authors:  C Boshoff; T F Schulz; M M Kennedy; A K Graham; C Fisher; A Thomas; J O McGee; R A Weiss; J J O'Leary
Journal:  Nat Med       Date:  1995-12       Impact factor: 53.440

10.  The Epstein-Barr virus G-protein-coupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation.

Authors:  Jianmin Zuo; Andrew Currin; Bryan D Griffin; Claire Shannon-Lowe; Wendy A Thomas; Maaike E Ressing; Emmanuel J H J Wiertz; Martin Rowe
Journal:  PLoS Pathog       Date:  2009-01-02       Impact factor: 6.823
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  40 in total

Review 1.  Viral manipulation of the host immune response.

Authors:  Allison Christiaansen; Steven M Varga; Juliet V Spencer
Journal:  Curr Opin Immunol       Date:  2015-07-10       Impact factor: 7.486

Review 2.  The human cytomegalovirus chemokine receptor homolog encoded by US27.

Authors:  James R Stegman; Barry J Margulies
Journal:  Virus Genes       Date:  2017-04-26       Impact factor: 2.332

Review 3.  Herpesvirus-bacteria synergistic interaction in periodontitis.

Authors:  Casey Chen; Pinghui Feng; Jørgen Slots
Journal:  Periodontol 2000       Date:  2020-02       Impact factor: 7.589

4.  The HCMV US28 vGPCR induces potent Gαq/PLC-β signaling in monocytes leading to increased adhesion to endothelial cells.

Authors:  Shu-En Wu; William E Miller
Journal:  Virology       Date:  2016-08-04       Impact factor: 3.616

Review 5.  Current and potential treatments for ubiquitous but neglected herpesvirus infections.

Authors:  Jonathan E Gable; Timothy M Acker; Charles S Craik
Journal:  Chem Rev       Date:  2014-10-02       Impact factor: 60.622

Review 6.  Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand.

Authors:  Raise Ahmad; Stefanie Wojciech; Ralf Jockers
Journal:  Br J Pharmacol       Date:  2014-12-15       Impact factor: 8.739

7.  Cytomegalovirus Restructures Lipid Rafts via a US28/CDC42-Mediated Pathway, Enhancing Cholesterol Efflux from Host Cells.

Authors:  Hann Low; Nigora Mukhamedova; Huanhuan L Cui; Brian P McSharry; Selmir Avdic; Anh Hoang; Michael Ditiatkovski; Yingying Liu; Ying Fu; Peter J Meikle; Martin Blomberg; Konstantinos A Polyzos; William E Miller; Piotr Religa; Michael Bukrinsky; Cecilia Soderberg-Naucler; Barry Slobedman; Dmitri Sviridov
Journal:  Cell Rep       Date:  2016-06-16       Impact factor: 9.423

Review 8.  Chemokines encoded by herpesviruses.

Authors:  Sergio M Pontejo; Philip M Murphy
Journal:  J Leukoc Biol       Date:  2017-08-28       Impact factor: 4.962

9.  The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties.

Authors:  Jeffrey R van Senten; Maarten P Bebelman; Tian Shu Fan; Raimond Heukers; Nick D Bergkamp; Puck van Gasselt; Ellen V Langemeijer; Erik Slinger; Tonny Lagerweij; Afsar Rahbar; Marijke Stigter-van Walsum; David Maussang; Rob Leurs; René J P Musters; Guus A M S van Dongen; Cecilia Söderberg-Nauclér; Thomas Würdinger; Marco Siderius; Martine J Smit
Journal:  J Biol Chem       Date:  2019-09-13       Impact factor: 5.157

Review 10.  Hijacking GPCRs by viral pathogens and tumor.

Authors:  Junjie Zhang; Hao Feng; Simin Xu; Pinghui Feng
Journal:  Biochem Pharmacol       Date:  2016-04-06       Impact factor: 5.858
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