Literature DB >> 21489891

The dual role of the X-linked FoxP3 gene in human cancers.

Margaret Redpath1, Bin Xu, Leon C van Kempen, Alan Spatz.   

Abstract

The FoxP3 (forkhead box P3) gene is an X-linked gene that is submitted to inactivation. It is an essential transcription factor in CD4(+)CD25(+)FoxP3 regulatory T cells, which are therapeutic targets in disseminated cutaneous melanoma. Moreover, FoxP3 is an important tumor suppressor gene in carcinomas and has putative cancer suppressor gene function in cutaneous melanoma as well. Therefore understanding the structure and function of the FoxP3 gene is crucial to gaining insight into the biology of melanoma to better develop immunotherapeutics and future therapeutic strategies.
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21489891      PMCID： PMC5528280          DOI： 10.1016/j.molonc.2011.03.001

Source DB:  PubMed          Journal:  Mol Oncol        ISSN： 1574-7891            Impact factor:   6.603


  111 in total

Review 1.  A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

Authors:  Jason D Fontenot; Alexander Y Rudensky
Journal:  Nat Immunol       Date:  2005-04       Impact factor: 25.606

2.  Circulating regulatory T cells (CD4+CD25+FOXP3+) decrease in breast cancer patients after vaccination with a modified MHC class II HER2/neu (AE37) peptide.

Authors:  Jeremy D Gates; Guy T Clifton; Linda C Benavides; Alan K Sears; Mark G Carmichael; Matthew T Hueman; Jarrod P Holmes; Yusuf H Jama; Mohamed Mursal; Athina Zacharia; Kathy Ciano; Steven Khoo; Alexander Stojadinovic; Sathibalan Ponniah; George E Peoples
Journal:  Vaccine       Date:  2010-09-19       Impact factor: 3.641

3.  Transforming growth factor beta 1 (TGF-beta1) and rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3+ Tregs.

Authors:  Koichi Kawamoto; Anil Pahuja; Bernhard J Hering; Pratima Bansal-Pakala
Journal:  Transpl Immunol       Date:  2010-03-19       Impact factor: 1.708

Review 4.  Human FoxP3(+)CD4(+) regulatory T cells: their knowns and unknowns.

Authors:  Makoto Miyara; Shimon Sakaguchi
Journal:  Immunol Cell Biol       Date:  2011-02-08       Impact factor: 5.126

5.  Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25- TGF-beta 1+ adaptive regulatory T cells.

Authors:  Ruobing Li; Nicolas Perez; Subha Karumuthil-Melethil; Bellur S Prabhakar; Mark J Holterman; Chenthamarakshan Vasu
Journal:  J Immunol       Date:  2007-10-15       Impact factor: 5.422

6.  Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.

Authors:  Girdhari Lal; Nan Zhang; William van der Touw; Yaozhong Ding; Wenjun Ju; Erwin P Bottinger; St Patrick Reid; David E Levy; Jonathan S Bromberg
Journal:  J Immunol       Date:  2009-01-01       Impact factor: 5.422

7.  Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome.

Authors:  Qingguo Ruan; Vasumathi Kameswaran; Yukiko Tone; Li Li; Hsiou-Chi Liou; Mark I Greene; Masahide Tone; Youhai H Chen
Journal:  Immunity       Date:  2009-12-18       Impact factor: 31.745

8.  Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1.

Authors:  Nadia Ouaked; Pierre-Yves Mantel; Claudio Bassin; Simone Burgler; Kerstin Siegmund; Cezmi A Akdis; Carsten B Schmidt-Weber
Journal:  J Immunol       Date:  2009-01-15       Impact factor: 5.422

9.  FOXP3 controls regulatory T cell function through cooperation with NFAT.

Authors:  Yongqing Wu; Madhuri Borde; Vigo Heissmeyer; Markus Feuerer; Ariya D Lapan; James C Stroud; Darren L Bates; Liang Guo; Aidong Han; Steven F Ziegler; Diane Mathis; Christophe Benoist; Lin Chen; Anjana Rao
Journal:  Cell       Date:  2006-07-28       Impact factor: 41.582

10.  Foxp3 expression in human cancer cells.

Authors:  Vaios Karanikas; Matthaios Speletas; Maria Zamanakou; Fani Kalala; Gedeon Loules; Theodora Kerenidi; Angeliki K Barda; Konstantinos I Gourgoulianis; Anastasios E Germenis
Journal:  J Transl Med       Date:  2008-04-22       Impact factor: 5.531
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  15 in total

1.  Study of circulating antibodies against CD25 and FOXP3 in breast cancer.

Authors:  Tong Liu; Yan-ni Song; Qing-Yu Shi; Yang Liu; Xia-nan Bai; Da Pang
Journal:  Tumour Biol       Date:  2013-12-18

Review 2.  The dual role of the X-linked FoxP3 gene in human cancers.

Authors:  Margaret Redpath; Bin Xu; Leon C van Kempen; Alan Spatz
Journal:  Mol Oncol       Date:  2011-03-30       Impact factor: 6.603

3.  CD44 induces FOXP3 expression and is related with favorable outcome in breast carcinoma.

Authors:  Elena Sanmartín; Fernando Ortiz-Martínez; Eloy Pomares-Navarro; Araceli García-Martínez; Montserrat Rodrigo-Baños; Marta García-Escolano; Leire Andrés; Enrique Lerma; Francisco I Aranda; Pascual Martínez-Peinado; José M Sempere-Ortells; Gloria Peiró
Journal:  Virchows Arch       Date:  2016-11-24       Impact factor: 4.064

4.  FoxP3 expression by retinal pigment epithelial cells: transcription factor with potential relevance for the pathology of age-related macular degeneration.

Authors:  Nadine Reichhart; Gerhild Wildner; Olaf Strauß; Ahmad Samir Alfaar; Lucas Stürzbecher; Maria Diedrichs-Möhring; Marion Lam; Christophe Roubeix; Julia Ritter; Kathrin Schumann; Balasubramaniam Annamalai; Inga-Marie Pompös; Bärbel Rohrer; Florian Sennlaub
Journal:  J Neuroinflammation       Date:  2022-10-22       Impact factor: 9.587

5.  Circulating autoantibody to FOXP3 may be a potential biomarker for esophageal squamous cell carcinoma.

Authors:  Leiguang Ye; Songlei Guan; Cong Zhang; Kuang-Hui Lee; Shilong Sun; Jun Wei; Baogang Liu
Journal:  Tumour Biol       Date:  2013-03-13

6.  A study of circulating anti-CD25 antibodies in non-small cell lung cancer.

Authors:  L Ye; X Li; S Sun; S Guan; M Wang; X Guan; K-H Lee; J Wei; B Liu
Journal:  Clin Transl Oncol       Date:  2012-12-21       Impact factor: 3.405

7.  Overexpression of the transcription factor FOXP3 in lung adenocarcinoma sustains malignant character by promoting G1/S transition gene CCND1.

Authors:  Yinan Li; Dong Li; Wei Yang; Haiying Fu; Yaqing Liu; Yi Li
Journal:  Tumour Biol       Date:  2015-12-16

Review 8.  Searching for the Achilles Heel of FOXP3.

Authors:  Teresa Lozano; Noelia Casares; Juan José Lasarte
Journal:  Front Oncol       Date:  2013-12-03       Impact factor: 6.244

Review 9.  The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis.

Authors:  Paul Laissue
Journal:  Mol Cancer       Date:  2019-01-08       Impact factor: 27.401

10.  FOXP3 Activates SUMO-Conjugating UBC9 Gene in MCF7 Breast Cancer Cells.

Authors:  Chiung-Min Wang; William H Yang; Runhua Liu; Lizhong Wang; Wei-Hsiung Yang
Journal:  Int J Mol Sci       Date:  2018-07-13       Impact factor: 5.923
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