Literature DB >> 21486958

Antimalarial effects of human immunodeficiency virus protease inhibitors in rhesus macaques.

Youjia Li1, Li Qin, Nanzheng Peng, Guangjie Liu, Siting Zhao, Zhengxiang He, Xiaoping Chen.   

Abstract

The antimalarial activity of the human immunodeficiency virus protease inhibitors indinavir and saquinavir was evaluated in rhesus macaques for the first time. Indinavir effectively suppressed the growth of Plasmodium cynomolgi and Plasmodium knowlesi in vivo after a 7- or 3-day treatment, respectively, with clinically relevant doses, whereas saquinavir showed only weak activity against P. cynomolgi.

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Year:  2011        PMID： 21486958      PMCID： PMC3101393          DOI： 10.1128/AAC.00085-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir.

Authors:  V A Eagling; D J Back; M G Barry
Journal:  Br J Clin Pharmacol       Date:  1997-08       Impact factor: 4.335

2.  Antiretrovirals as antimalarial agents.

Authors:  Tina S Skinner-Adams; James S McCarthy; Donald L Gardiner; Petrina M Hilton; Katherine T Andrews
Journal:  J Infect Dis       Date:  2004-11-03       Impact factor: 5.226

3.  Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors.

Authors:  Andrea Savarino; Roberto Cauda; Antonio Cassone
Journal:  J Infect Dis       Date:  2005-04-15       Impact factor: 5.226

4.  Synergy of the antiretroviral protease inhibitor indinavir and chloroquine against malaria parasites in vitro and in vivo.

Authors:  Xiaofen Li; Zhengxiang He; Lili Chen; Yayong Li; Qinyan Li; Siting Zhao; Zhu Tao; Wen Hu; Li Qin; Xiaoping Chen
Journal:  Parasitol Res       Date:  2011-05-03       Impact factor: 2.289

Review 5.  Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection.

Authors:  M Barry; F Mulcahy; C Merry; S Gibbons; D Back
Journal:  Clin Pharmacokinet       Date:  1999-04       Impact factor: 6.447

6.  Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors.

Authors:  Sunil Parikh; Jiri Gut; Eva Istvan; Daniel E Goldberg; Diane V Havlir; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

7.  Evolutionary relatedness of some primate models of Plasmodium.

Authors:  A P Waters; D G Higgins; T F McCutchan
Journal:  Mol Biol Evol       Date:  1993-07       Impact factor: 16.240

8.  L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor.

Authors:  B D Dorsey; R B Levin; S L McDaniel; J P Vacca; J P Guare; P L Darke; J A Zugay; E A Emini; W A Schleif; J C Quintero
Journal:  J Med Chem       Date:  1994-10-14       Impact factor: 7.446

9.  HIV infection as a cofactor for severe falciparum malaria in adults living in a region of unstable malaria transmission in South Africa.

Authors:  Kate Grimwade; Neil French; Daniel D Mbatha; Dawn D Zungu; Martin Dedicoat; Charles F Gilks
Journal:  AIDS       Date:  2004-02-20       Impact factor: 4.177

10.  Naturally acquired Plasmodium knowlesi malaria in human, Thailand.

Authors:  Somchai Jongwutiwes; Chaturong Putaporntip; Takuya Iwasaki; Tetsutaro Sata; Hiroji Kanbara
Journal:  Emerg Infect Dis       Date:  2004-12       Impact factor: 6.883
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  4 in total

1.  HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo.

Authors:  Charlotte V Hobbs; Jillian Neal; Solomon Conteh; Liam Donnelly; Jingyang Chen; Kennan Marsh; Lynn Lambert; Sachy Orr-Gonzalez; Jessica Hinderer; Sara Healy; William Borkowsky; Scott R Penzak; Sumana Chakravarty; Stephen L Hoffman; Patrick E Duffy
Journal:  PLoS One       Date:  2014-07-02       Impact factor: 3.240

2.  Neither the HIV protease inhibitor lopinavir-ritonavir nor the antimicrobial trimethoprim-sulfamethoxazole prevent malaria relapse in plasmodium cynomolgi-infected non-human primates.

Authors:  Charlotte V Hobbs; Saurabh Dixit; Scott R Penzak; Tejram Sahu; Sachy Orr-Gonzalez; Lynn Lambert; Katie Zeleski; Jingyang Chen; Jillian Neal; William Borkowsky; Yimin Wu; Patrick E Duffy
Journal:  PLoS One       Date:  2014-12-26       Impact factor: 3.240

3.  The Impact of Antiretroviral Therapy on Malaria Parasite Transmission.

Authors:  Raquel Azevedo; António M Mendes; Miguel Prudêncio
Journal:  Front Microbiol       Date:  2020-01-24       Impact factor: 5.640

Review 4.  Repurposing Drugs to Fight Hepatic Malaria Parasites.

Authors:  Diana Fontinha; Isabel Moules; Miguel Prudêncio
Journal:  Molecules       Date:  2020-07-28       Impact factor: 4.411
  4 in total

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