Literature DB >> 21486861

Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity.

Caroline Jochems1, Jeffrey Schlom.   

Abstract

Numerous studies have now documented a link between the immune infiltrate in several human carcinoma types and prognosis and response to therapy. The most comprehensive of these studies were in colorectal cancer with similar conclusions by numerous groups. Analyses of immune infiltrate of several other carcinoma types also showed general correlations between immune infiltrate and prognosis, but with some conflicting results. This review will attempt to summarize the current state of this field and point out what factors may be responsible for some of the conflicting findings. Nonetheless, the breadth of reports drawing similar conclusions for some cancer cell types leads one to more seriously consider the link between immune cell infiltrate and tumor prognosis and/or response to therapy, and the potential for combining conventional cancer therapy with active immunotherapy employing therapeutic cancer vaccines.

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Mesh：

Year:  2011        PMID： 21486861      PMCID： PMC3229261          DOI： 10.1258/ebm.2011.011007

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  74 in total

1.  Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas.

Authors:  K Schumacher; W Haensch; C Röefzaad; P M Schlag
Journal:  Cancer Res       Date:  2001-05-15       Impact factor: 12.701

2.  Microsatellite instability and high content of activated cytotoxic lymphocytes identify colon cancer patients with a favorable prognosis.

Authors:  M Guidoboni; R Gafà; A Viel; C Doglioni; A Russo; A Santini; L Del Tin; E Macrì; G Lanza; M Boiocchi; R Dolcetti
Journal:  Am J Pathol       Date:  2001-07       Impact factor: 4.307

3.  CD4+ and CD8+ T cells cooperate to improve prognosis of patients with esophageal squamous cell carcinoma.

Authors:  Yasushi Cho; Masaki Miyamoto; Kentaro Kato; Akira Fukunaga; Toshiaki Shichinohe; You Kawarada; Yasuhiro Hida; Taro Oshikiri; Takanori Kurokawa; Masato Suzuoki; Yoshihiro Nakakubo; Kei Hiraoka; Soichi Murakami; Toshiya Shinohara; Tomoo Itoh; Shunichi Okushiba; Satoshi Kondo; Hiroyuki Katoh
Journal:  Cancer Res       Date:  2003-04-01       Impact factor: 12.701

4.  Infiltration of CD8+ T cells in non-small cell lung cancer is associated with dedifferentiation of cancer cells, but not with prognosis.

Authors:  M Mori; H Ohtani; Y Naito; M Sagawa; M Sato; S Fujimura; H Nagura
Journal:  Tohoku J Exp Med       Date:  2000-06       Impact factor: 1.848

5.  Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status.

Authors:  J M Michael-Robinson; A Biemer-Hüttmann; D M Purdie; M D Walsh; L A Simms; K G Biden; J P Young; B A Leggett; J R Jass; G L Radford-Smith
Journal:  Gut       Date:  2001-03       Impact factor: 23.059

6.  Prognostic value of the CD4+/CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells.

Authors:  Axel C P Diederichsen; J v B Hjelmborg; Per B Christensen; Jesper Zeuthen; Claus Fenger
Journal:  Cancer Immunol Immunother       Date:  2003-04-15       Impact factor: 6.968

7.  Effect of tumor-infiltrating lymphocyte subsets on prognosis and susceptibility to interferon therapy in patients with renal cell carcinoma.

Authors:  Tatsuo Igarashi; Hidenori Takahashi; Toyofusa Tobe; Hiroyoshi Suzuki; Kenichi Mizoguchi; Hiro-omi Nakatsu; Haruo Ito
Journal:  Urol Int       Date:  2002       Impact factor: 2.089

8.  Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.

Authors:  Lin Zhang; Jose R Conejo-Garcia; Dionyssios Katsaros; Phyllis A Gimotty; Marco Massobrio; Giorgia Regnani; Antonis Makrigiannakis; Heidi Gray; Katia Schlienger; Michael N Liebman; Stephen C Rubin; George Coukos
Journal:  N Engl J Med       Date:  2003-01-16       Impact factor: 91.245

9.  Clinical significance of immune cell infiltration within gallbladder cancer.

Authors:  Y Nakakubo; M Miyamoto; Y Cho; Y Hida; T Oshikiri; M Suzuoki; K Hiraoka; T Itoh; S Kondo; H Katoh
Journal:  Br J Cancer       Date:  2003-11-03       Impact factor: 7.640

10.  The relationship between T-lymphocyte infiltration, stage, tumour grade and survival in patients undergoing curative surgery for renal cell cancer.

Authors:  E J Bromwich; P A McArdle; K Canna; D C McMillan; A-M McNicol; M Brown; M Aitchison
Journal:  Br J Cancer       Date:  2003-11-17       Impact factor: 7.640
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  127 in total

1.  Finding an Immunologic Beachhead in the Prostate Cancer Microenvironment.

Authors:  Ravi A Madan; James L Gulley
Journal:  J Natl Cancer Inst       Date:  2019-03-01       Impact factor: 13.506

2.  Comparison of circulating and intratumoral regulatory T cells in patients with renal cell carcinoma.

Authors:  Gati Asma; Gorrab Amal; Marrakchi Raja; Derouiche Amine; Chebil Mohammed; Ben Ammar Elgaaied Amel
Journal:  Tumour Biol       Date:  2015-01-07

Review 3.  Immunotherapy of hepatocellular carcinoma using chimeric antigen receptors and bispecific antibodies.

Authors:  Sayed Shahabuddin Hoseini; Nai-Kong V Cheung
Journal:  Cancer Lett       Date:  2017-04-17       Impact factor: 8.679

4.  Intratumoral regulatory T cells alone or in combination with cytotoxic T cells predict prognosis of hepatocellular carcinoma after resection.

Authors:  Kang-jie Chen; Lin Zhou; Hai-yang Xie; Taki-eldin Ahmed; Xiao-wen Feng; Shu-sen Zheng
Journal:  Med Oncol       Date:  2011-06-16       Impact factor: 3.064

Review 5.  The role of tumor microenvironment in melanoma therapy resistance.

Authors:  Rajasekharan Somasundaram; Meenhard Herlyn; Stephan N Wagner
Journal:  Melanoma Manag       Date:  2016-02-12

6.  An Overview of Advances in Cell-Based Cancer Immunotherapies Based on the Multiple Immune-Cancer Cell Interactions.

Authors:  Jialing Zhang; Stephan S Späth; Sherman M Weissman; Samuel G Katz
Journal:  Methods Mol Biol       Date:  2020

Review 7.  Complex interplay between tumor microenvironment and cancer therapy.

Authors:  Minhong Shen; Yibin Kang
Journal:  Front Med       Date:  2018-08-10       Impact factor: 4.592

Review 8.  Adequate antigen availability: a key issue for novel approaches to tumor vaccination and tumor immunotherapy.

Authors:  Roberto S Accolla; Giovanna Tosi
Journal:  J Neuroimmune Pharmacol       Date:  2012-12-07       Impact factor: 4.147

9.  Strategies for optimizing the clinical impact of immunotherapeutic agents such as sipuleucel-T in prostate cancer.

Authors:  Ravi A Madan; Thomas Schwaab; James L Gulley
Journal:  J Natl Compr Canc Netw       Date:  2012-12-01       Impact factor: 11.908

10.  Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.

Authors:  Yuhui Huang; Jianping Yuan; Elda Righi; Walid S Kamoun; Marek Ancukiewicz; Jean Nezivar; Michael Santosuosso; John D Martin; Margaret R Martin; Fabrizio Vianello; Pierre Leblanc; Lance L Munn; Peigen Huang; Dan G Duda; Dai Fukumura; Rakesh K Jain; Mark C Poznansky
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-08       Impact factor: 11.205
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