Literature DB >> 10946920

Infiltration of CD8+ T cells in non-small cell lung cancer is associated with dedifferentiation of cancer cells, but not with prognosis.

M Mori1, H Ohtani, Y Naito, M Sagawa, M Sato, S Fujimura, H Nagura.   

Abstract

CD8+ T cells infiltrating within cancer cell nests in human colorectal cancer were associated with a favorable patients' survival, suggesting the presence of anti-tumor immunity. The present study was designed to examine this concept in non-small cell lung cancer (NSCLC) by a retrospective analysis of 128 surgically resected cases. Immunohistochemical analysis showed that the number of CD8+ T cells within cancer cell nests in NSCLC was related to the histological subtype (large cell carcinoma or squamous cell carcinoma > adenocarcinoma) and the degree of dedifferentiation (undifferentiated type > differentiated type). In contrast to colorectal cancer, the number of CD8+ T cells in NSCLC had no statistically significant impact on the patients' survival. The present study demonstrated that the degree of infiltration of CD8+ T cells within cancer cell nests is dependent on the dedifferentiation of cancer cells in NSCLC, which could be one of the important aspects for the study of tumor immunity.

Entities:  

Mesh：

Year:  2000        PMID： 10946920     DOI： 10.1620/tjem.191.113

Source DB:  PubMed          Journal:  Tohoku J Exp Med        ISSN： 0040-8727            Impact factor:   1.848


  20 in total

1.  Preoperative lymphocyte count is a favorable prognostic factor of disease-free survival in non-small-cell lung cancer.

Authors:  Jian Zhang; Shao-Hong Huang; Hui Li; Yun Li; Xiu-Ling Chen; Wei-Qing Zhang; Hui-Guo Chen; Li-Jia Gu
Journal:  Med Oncol       Date:  2012-12-30       Impact factor: 3.064

Review 2.  Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity.

Authors:  Caroline Jochems; Jeffrey Schlom
Journal:  Exp Biol Med (Maywood)       Date:  2011-04-12

3.  Heterogeneity of CD8+ tumor-infiltrating lymphocytes in non-small-cell lung cancer: impact on patient prognostic assessments and comparison of quantification by different sampling strategies.

Authors:  Joseph M Obeid; Nolan A Wages; Yinin Hu; Donna H Deacon; Craig L Slingluff
Journal:  Cancer Immunol Immunother       Date:  2016-10-21       Impact factor: 6.968

Review 4.  The immune response in cancer: from immunology to pathology to immunotherapy.

Authors:  Nicolas A Giraldo; Etienne Becht; Yann Vano; Catherine Sautès-Fridman; Wolf H Fridman
Journal:  Virchows Arch       Date:  2015-06-16       Impact factor: 4.064

5.  Image Analysis-based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non-small Cell Lung Carcinoma Patients.

Authors:  Edwin R Parra; Carmen Behrens; Jaime Rodriguez-Canales; Heather Lin; Barbara Mino; Jorge Blando; Jianjun Zhang; Don L Gibbons; John V Heymach; Boris Sepesi; Stephen G Swisher; Annikka Weissferdt; Neda Kalhor; Julie Izzo; Humam Kadara; Cesar Moran; Jack J Lee; Ignacio I Wistuba
Journal:  Clin Cancer Res       Date:  2016-06-01       Impact factor: 12.531

6.  Expression of cancer-testis antigens MAGE-A3/6 and NY-ESO-1 in non-small-cell lung carcinomas and their relationship with immune cell infiltration.

Authors:  Sang Hyun Kim; Sangyull Lee; Chang Hun Lee; Min Ki Lee; Young Dae Kim; Dong Hoon Shin; Kyung Un Choi; Jee Yeon Kim; Do Youn Park; Mee Young Sol
Journal:  Lung       Date:  2009-10-01       Impact factor: 2.584

7.  Objective measurement and clinical significance of TILs in non-small cell lung cancer.

Authors:  Kurt A Schalper; Jason Brown; Daniel Carvajal-Hausdorf; Joseph McLaughlin; Vamsidhar Velcheti; Konstantinos N Syrigos; Roy S Herbst; David L Rimm
Journal:  J Natl Cancer Inst       Date:  2015-02-03       Impact factor: 11.816

8.  Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma.

Authors:  K Hiraoka; M Miyamoto; Y Cho; M Suzuoki; T Oshikiri; Y Nakakubo; T Itoh; T Ohbuchi; S Kondo; H Katoh
Journal:  Br J Cancer       Date:  2006-01-30       Impact factor: 7.640

9.  Local CD4+, CD8+ and CD56+ T-lymphocite Reaction on Primary Lung Cancer.

Authors:  Edin Jusufovic; Besim Prnjavorac; Ermina Iljazovic; Mitja Kosnik; Dragan Keser; Peter Korosec; Jugoslav Stahov; Edin Zukic; Rifat Sejdinovic; Ekrem Ajanovic
Journal:  Acta Inform Med       Date:  2011-09

Review 10.  Patient-tailored modulation of the immune system may revolutionize future lung cancer treatment.

Authors:  Marlies E Heuvers; Joachim G Aerts; Robin Cornelissen; Harry Groen; Henk C Hoogsteden; Joost P Hegmans
Journal:  BMC Cancer       Date:  2012-12-05       Impact factor: 4.430
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