Literature DB >> 21486034

Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): a HYSCORE Investigation.

Weixue Wang1, Jikun Li, Ke Wang, Tatyana I Smirnova, Eric Oldfield.   

Abstract

IspH is a 4Fe-4S protein that carries out an essential reduction step in isoprenoid biosynthesis. Using hyperfine sublevel correlation (HYSCORE) spectroscopy, we show that pyridine inhibitors of IspH directly bind to the unique fourth Fe in the 4Fe-4S cluster, opening up new routes to inhibitor design, of interest in the context of both anti-bacterial as well as anti-malarial drug discovery.
© 2011 American Chemical Society

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Year:  2011        PMID： 21486034      PMCID： PMC3092291          DOI： 10.1021/ja2008455

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  23 in total

1.  Isoprenoid biosynthesis through the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) is a [4Fe-4S] protein.

Authors:  Myriam Seemann; Bernadette Tse Sum Bui; Murielle Wolff; Denis Tritsch; Narciso Campos; Albert Boronat; Andrée Marquet; Michel Rohmer
Journal:  Angew Chem Int Ed Engl       Date:  2002-11-15       Impact factor: 15.336

2.  Bioorganometallic mechanism of action, and inhibition, of IspH.

Authors:  Weixue Wang; Ke Wang; Yi-Liang Liu; Joo-Hwan No; Jikun Li; Mark J Nilges; Eric Oldfield
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-19       Impact factor: 11.205

3.  EasySpin, a comprehensive software package for spectral simulation and analysis in EPR.

Authors:  Stefan Stoll; Arthur Schweiger
Journal:  J Magn Reson       Date:  2005-09-26       Impact factor: 2.229

4.  Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein.

Authors:  S Hecht; W Eisenreich; P Adam; S Amslinger; K Kis; A Bacher; D Arigoni; F Rohdich
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-18       Impact factor: 11.205

5.  Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis.

Authors:  Ann-Kristin Kollas; Evert C Duin; Matthias Eberl; Boran Altincicek; Martin Hintz; Armin Reichenberg; Dajana Henschker; Anke Henne; Irina Steinbrecher; Dmitry N Ostrovsky; Reiner Hedderich; Ewald Beck; Hassan Jomaa; Jochen Wiesner
Journal:  FEBS Lett       Date:  2002-12-18       Impact factor: 4.124

6.  Probing the reaction mechanism of IspH protein by x-ray structure analysis.

Authors:  Tobias Gräwert; Ingrid Span; Wolfgang Eisenreich; Felix Rohdich; Jörg Eppinger; Adelbert Bacher; Michael Groll
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-28       Impact factor: 11.205

7.  Electron spin echo envelope modulation spectroscopy supports the suggested coordination of two histidine ligands to the Rieske Fe-S centers of the cytochrome b6f complex of spinach and the cytochrome bc1 complexes of Rhodospirillum rubrum, Rhodobacter sphaeroides R-26, and bovine heart mitochondria.

Authors:  R D Britt; K Sauer; M P Klein; D B Knaff; A Kriauciunas; C A Yu; L Yu; R Malkin
Journal:  Biochemistry       Date:  1991-02-19       Impact factor: 3.162

8.  Evaluation of nitrogen nuclear hyperfine and quadrupole coupling parameters for the proximal imidazole in myoglobin-azide, -cyanide, and -mercaptoethanol complexes by electron spin echo envelope modulation spectroscopy.

Authors:  R S Magliozzo; J Peisach
Journal:  Biochemistry       Date:  1993-08-24       Impact factor: 3.162

9.  Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway.

Authors:  Ingo Rekittke; Jochen Wiesner; Rene Röhrich; Ulrike Demmer; Eberhard Warkentin; Weiya Xu; Kathrin Troschke; Martin Hintz; Joo Hwan No; Evert C Duin; Eric Oldfield; Hassan Jomaa; Ulrich Ermler
Journal:  J Am Chem Soc       Date:  2008-12-24       Impact factor: 15.419

10.  Electron spin echo envelope modulation spectroscopic study of iron-nitrogen interactions in myoglobin hydroxide and Fe(III) tetraphenylporphyrin models.

Authors:  R S Magliozzo; J Peisach
Journal:  Biochemistry       Date:  1992-01-14       Impact factor: 3.162
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  13 in total

1.  Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins.

Authors:  Yi-Liang Liu; Francisco Guerra; Ke Wang; Weixue Wang; Jikun Li; Cancan Huang; Wei Zhu; Kevin Houlihan; Zhi Li; Yong Zhang; Satish K Nair; Eric Oldfield
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-14       Impact factor: 11.205

2.  Biosynthesis of isoprene units: Mössbauer spectroscopy of substrate and inhibitor binding to the [4Fe-4S] cluster of the LytB/IspH enzyme.

Authors:  Annegret Ahrens-Botzong; Karnjapan Janthawornpong; Juliusz A Wolny; Erasmienne Ngouamegne Tambou; Michel Rohmer; Sergiy Krasutsky; C Dale Poulter; Volker Schünemann; Myriam Seemann
Journal:  Angew Chem Int Ed Engl       Date:  2011-10-19       Impact factor: 15.336

3.  Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation.

Authors:  Weixue Wang; Ke Wang; Ingrid Span; Johann Jauch; Adelbert Bacher; Michael Groll; Eric Oldfield
Journal:  J Am Chem Soc       Date:  2012-06-28       Impact factor: 15.419

Review 4.  Bioorganometallic chemistry with IspG and IspH: structure, function, and inhibition of the [Fe(4)S(4)] proteins involved in isoprenoid biosynthesis.

Authors:  Weixue Wang; Eric Oldfield
Journal:  Angew Chem Int Ed Engl       Date:  2014-01-31       Impact factor: 15.336

5.  Selective inhibition of E. coli 1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates().

Authors:  Jessica M Smith; Ryan J Vierling; Caren Freel Meyers
Journal:  Medchemcomm       Date:  2011-10-26       Impact factor: 3.597

6.  Inhibition of the 4Fe-4S Proteins IspG and IspH: an EPR, ENDOR and HYSCORE Investigation.

Authors:  Francisco Guerra; Ke Wang; Jikun Li; Weixue Wang; Yi-Liang Liu; Shivani Amin; Eric Oldfield
Journal:  Chem Sci       Date:  2014-04-01       Impact factor: 9.825

7.  Inhibition of IspH, a [4Fe-4S]2+ enzyme involved in the biosynthesis of isoprenoids via the methylerythritol phosphate pathway.

Authors:  Karnjapan Janthawornpong; Sergiy Krasutsky; Philippe Chaignon; Michel Rohmer; C Dale Poulter; Myriam Seemann
Journal:  J Am Chem Soc       Date:  2013-01-29       Impact factor: 15.419

8.  An EPR/HYSCORE, Mössbauer, and resonance Raman study of the hydrogenase maturation enzyme HydF: a model for N-coordination to [4Fe-4S] clusters.

Authors:  Gustav Berggren; Ricardo Garcia-Serres; Xavier Brazzolotto; Martin Clemancey; Serge Gambarelli; Mohamed Atta; Jean-Marc Latour; Heather L Hernández; Sowmya Subramanian; Michael K Johnson; Marc Fontecave
Journal:  J Biol Inorg Chem       Date:  2013-11-17       Impact factor: 3.358

9.  Broken-Symmetry DFT Computations for the Reaction Pathway of IspH, an Iron-Sulfur Enzyme in Pathogenic Bacteria.

Authors:  Patrick G Blachly; Gregory M Sandala; Debra Ann Giammona; Donald Bashford; J Andrew McCammon; Louis Noodleman
Journal:  Inorg Chem       Date:  2015-06-22       Impact factor: 5.165

10.  Utilizing a dynamical description of IspH to aid in the development of novel antimicrobial drugs.

Authors:  Patrick G Blachly; César A F de Oliveira; Sarah L Williams; J Andrew McCammon
Journal:  PLoS Comput Biol       Date:  2013-12-19       Impact factor: 4.475
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