Literature DB >> 21485840

EGFR targeted PLGA nanoparticles using gemcitabine for treatment of pancreatic cancer.

Sahil Aggarwal1, Sachin Yadav, Swati Gupta.   

Abstract

The present study aimed to prepare and characterize anti EGFR monoclonal antibody (mab) conjugated Gemcitabine loaded PLGA nanoparticles for their selective delivery to pancreatic cells and evaluation of the systems in vitro. It was observed that direct covalent coupling of antibodies to glutaraldehyde activated nanoparticles is an appropriate method to achieve cell-type specific drug carrier systems based on polymeric nanoparticles that have potential to be applied for targeted chemotherapy in EGFR positive cancer.

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Year:  2011        PMID： 21485840     DOI： 10.1166/jbn.2011.1238

Source DB:  PubMed          Journal:  J Biomed Nanotechnol        ISSN： 1550-7033            Impact factor:   4.099


  11 in total

1.  Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer.

Authors:  Lei Miao; Shutao Guo; Jing Zhang; William Y Kim; Leaf Huang
Journal:  Adv Funct Mater       Date:  2014-11-12       Impact factor: 18.808

Review 2.  Polymer nanoparticles for drug and small silencing RNA delivery to treat cancers of different phenotypes.

Authors:  Rammohan Devulapally; Ramasamy Paulmurugan
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2013-08-31

3.  Core-shell nanoparticulate formulation of gemcitabine: lyophilization, stability studies, and in vivo evaluation.

Authors:  Deepak Chitkara; Anupama Mittal; Ram I Mahato; Neeraj Kumar
Journal:  Drug Deliv Transl Res       Date:  2014-12       Impact factor: 4.617

4.  Current status of biomarker and targeted nanoparticle development: The precision oncology approach for pancreatic cancer therapy.

Authors:  Lei Zhu; Charles Staley; David Kooby; Bassel El-Rays; Hui Mao; Lily Yang
Journal:  Cancer Lett       Date:  2016-12-01       Impact factor: 8.679

Review 5.  EGF receptor-targeted nanocarriers for enhanced cancer treatment.

Authors:  Alyssa M Master; Anirban Sen Gupta
Journal:  Nanomedicine (Lond)       Date:  2012-12       Impact factor: 5.307

6.  Gemcitabine and Antisense-microRNA Co-encapsulated PLGA-PEG Polymer Nanoparticles for Hepatocellular Carcinoma Therapy.

Authors:  Rammohan Devulapally; Kira Foygel; Thillai V Sekar; Juergen K Willmann; Ramasamy Paulmurugan
Journal:  ACS Appl Mater Interfaces       Date:  2016-12-02       Impact factor: 9.229

7.  The eminent need for an academic program in universities to teach nanomedicine.

Authors:  Juan Manuel Vélez; Juan Jesus Vélez
Journal:  Int J Nanomedicine       Date:  2011-08-19

8.  Sustained release of VEGF from PLGA nanoparticles embedded thermo-sensitive hydrogel in full-thickness porcine bladder acellular matrix.

Authors:  Hongquan Geng; Hua Song; Jun Qi; Daxiang Cui
Journal:  Nanoscale Res Lett       Date:  2011-04-07       Impact factor: 4.703

Review 9.  Polymeric nanoparticles for targeted treatment in oncology: current insights.

Authors:  Rashmi H Prabhu; Vandana B Patravale; Medha D Joshi
Journal:  Int J Nanomedicine       Date:  2015-02-02

10.  Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia.

Authors:  Valeria Pereira de Sousa; Joanne Crean; Vinícius Raphael de Almeida Borges; Carlos Rangel Rodrigues; Lidia Tajber; Fabio Boylan; Lucio Mendes Cabral
Journal:  Int J Nanomedicine       Date:  2013-08-15
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