Literature DB >> 21485832

Loading and release of amphotericin-B from biodegradable poly(lactic-co-glycolic acid) nanoparticles.

Rahul K Verma1, Sanket Pandya, Amit Misra.   

Abstract

Amphotericin B (AmB)-loaded poly(lactic-co-glycolic acid, PLGA) nanoparticles (NP) were prepared by solvent displacement. NP of size 160.7 +/- 10.45 nm, with a polydispersity index of 0.093 +/- 0.012 and a zeta-potential of -15.5 +/- 7.2 mV had satisfactory drug entrapment efficiency (42.5 +/- 6.41%). Biphasic drug release characterized by an initial burst followed by subsequent sustained release was observed. Applicability against visceral leishmaniasis and cancer is under investigation.

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Year:  2011        PMID： 21485832     DOI： 10.1166/jbn.2011.1230

Source DB:  PubMed          Journal:  J Biomed Nanotechnol        ISSN： 1550-7033            Impact factor:   4.099


  5 in total

1.  Improved antifungal activity of amphotericin B-loaded TPGS-b-(PCL-ran-PGA) nanoparticles.

Authors:  Xiaolong Tang; Ronghong Jiao; Chunmei Xie; Lifa Xu; Zhen Huo; Jingjing Dai; Yunyun Qian; Weiwen Xu; Wei Hou; Jiang Wang; Yong Liang
Journal:  Int J Clin Exp Med       Date:  2015-04-15

Review 2.  Design of amphotericin B oral formulation for antifungal therapy.

Authors:  Min Liu; Meiwan Chen; Zhiwen Yang
Journal:  Drug Deliv       Date:  2017-11       Impact factor: 6.419

3.  Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals.

Authors:  Mohammad Farazuddin; Bhavyata Dua; Qamar Zia; Aijaz Ahmad Khan; Beenu Joshi; Mohammad Owais
Journal:  Int J Nanomedicine       Date:  2014-03-03

4.  Evaluating the potential of cubosomal nanoparticles for oral delivery of amphotericin B in treating fungal infection.

Authors:  Zhiwen Yang; Meiwan Chen; Muhua Yang; Jian Chen; Weijun Fang; Ping Xu
Journal:  Int J Nanomedicine       Date:  2014-01-06

5.  Supplementation of host response by targeting nitric oxide to the macrophage cytosol is efficacious in the hamster model of visceral leishmaniasis and adds to efficacy of amphotericin B.

Authors:  Sanketkumar Pandya; Rahul Kumar Verma; Prashant Khare; Brajendra Tiwari; Dadi A Srinivasarao; Anuradha Dube; Neena Goyal; Amit Misra
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2016-01-14       Impact factor: 4.077
  5 in total

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