| Literature DB >> 21482413 |
Jessica E Hall1, Wei Fu, Michael D Schaller.
Abstract
Focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) are closely related nonreceptor protein tyrosine kinases. FAK can regulate cell proliferation, survival, and motility, and plays an essential role in development. Pyk2 shares some functions with FAK but is a nonessential gene product during development. Recent discoveries related to FAK and Pyk2 structure have provided important insights into the regulatory mechanisms of catalytic activity, molecular basis of assembly of signaling complexes, and the transmission of downstream signals. This chapter reviews these advances in FAK/Pyk2 structure/function, compares and contrasts features of these kinases, and discusses new drug discoveries in the context of molecular structure.Entities:
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Year: 2011 PMID： 21482413 DOI： 10.1016/B978-0-12-386041-5.00005-4
Source DB: PubMed Journal: Int Rev Cell Mol Biol ISSN： 1937-6448 Impact factor: 6.813