Literature DB >> 22960604

Germinal center kinases in immune regulation.

Hailei Yin1, Zhubing Shi, Shi Jiao, Cuicui Chen, Wenjia Wang, Mark I Greene, Zhaocai Zhou.   

Abstract

Germinal center kinases (GCKs) participate in a variety of signaling pathways needed to regulate cellular functions including apoptosis, cell proliferation, polarity and migration. Recent studies have shown that GCKs are participants in both adaptive and innate immune regulation. However, the differential activation and regulatory mechanisms of GCKs, as well as upstream and downstream signaling molecules, remain to be fully defined. It remains unresolved whether and how GCKs may cross-talk with existing signaling pathways. This review stresses the progresses in research of GCKs relevant to the immune system.

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Year:  2012        PMID： 22960604      PMCID： PMC4002213          DOI： 10.1038/cmi.2012.30

Source DB:  PubMed          Journal:  Cell Mol Immunol        ISSN： 1672-7681            Impact factor:   11.530


  129 in total

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