Literature DB >> 21479864

Neurophysiological evaluation of the pedunculopontine nucleus in humans.

P Profice1, P Mazzone, F Pilato, M Dileone, A Insola, F Ranieri, V Di Lazzaro.   

Abstract

The pedunculopontine nucleus (PPTg) is constituted by a heterogeneous cluster of neurons located in caudal mesencephalic tegmentum which projects to the thalamus to trigger thalamocortical rhythms and the brainstem to modulate muscle tone and locomotion. It has been investigated as potential deep brain stimulation (DBS) target for treating Parkinson's disease (PD) symptoms. Neurophysiological studies conducted in humans using DBS electrodes for exploring functional properties of PPTg in vivo, reviewed in this paper, demonstrated that the functional connections between PPTg and cortex, basal ganglia, brainstem network involved in sleep/wake control, and spinal cord can be explored in vivo and provided useful insights about the physiology of this nucleus and pathophysiology of PD.

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Year:  2011        PMID： 21479864     DOI： 10.1007/s00702-011-0644-3

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  70 in total

1.  Neuronal excitability modulation over the sleep cycle: a structural and mathematical model.

Authors:  R W McCarley; J A Hobson
Journal:  Science       Date:  1975-07-04       Impact factor: 47.728

Review 2.  The pedunculopontine nucleus as a target for deep brain stimulation.

Authors:  Clement Hamani; Elena Moro; Andres M Lozano
Journal:  J Neural Transm (Vienna)       Date:  2010-12-31       Impact factor: 3.575

3.  Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease.

Authors:  Alessandro Stefani; Andres M Lozano; Antonella Peppe; Paolo Stanzione; Salvatore Galati; Domenicantonio Tropepi; Mariangela Pierantozzi; Livia Brusa; Eugenio Scarnati; Paolo Mazzone
Journal:  Brain       Date:  2007-01-24       Impact factor: 13.501

4.  A putative flip-flop switch for control of REM sleep.

Authors:  Jun Lu; David Sherman; Marshall Devor; Clifford B Saper
Journal:  Nature       Date:  2006-05-10       Impact factor: 49.962

5.  Sleep induced by stimulation in the human pedunculopontine nucleus area.

Authors:  Isabelle Arnulf; Muriel Ferraye; Valérie Fraix; Alim Louis Benabid; Stephan Chabardès; Laurent Goetz; Pierre Pollak; Bettina Debû
Journal:  Ann Neurol       Date:  2010-04       Impact factor: 10.422

6.  Origin of ascending and spinal pathways from the nucleus tegmenti pedunculopontinus in the rat.

Authors:  B M Spann; I Grofova
Journal:  J Comp Neurol       Date:  1989-05-01       Impact factor: 3.215

7.  Synaptic organization of the rat parafascicular nucleus, with special reference to its afferents from the superior colliculus and the pedunculopontine tegmental nucleus.

Authors:  Shigeo Kobayashi; Yasuhisa Nakamura
Journal:  Brain Res       Date:  2003-08-01       Impact factor: 3.252

8.  Oscillatory activity in the pedunculopontine area of patients with Parkinson's disease.

Authors:  Alexandros G Androulidakis; Paolo Mazzone; Vladimir Litvak; Will Penny; Michele Dileone; Louise M F Doyle Gaynor; Stephen Tisch; Vincenzo Di Lazzaro; Peter Brown
Journal:  Exp Neurol       Date:  2008-01-19       Impact factor: 5.330

Review 9.  Non-motor functions in parkinsonian patients implanted in the pedunculopontine nucleus: focus on sleep and cognitive domains.

Authors:  Stefani Alessandro; Roberto Ceravolo; Livia Brusa; Mariangela Pierantozzi; Alberto Costa; Salvatore Galati; Fabio Placidi; Andrea Romigi; Cesare Iani; Francesco Marzetti; Antonella Peppe
Journal:  J Neurol Sci       Date:  2009-09-17       Impact factor: 3.181

10.  Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients.

Authors:  Mariangela Pierantozzi; Maria Giuseppina Palmieri; Salvatore Galati; Paolo Stanzione; Antonella Peppe; Domenicantonio Tropepi; Livia Brusa; Antonio Pisani; Vincenzo Moschella; Maria Grazia Marciani; Paolo Mazzone; Alessandro Stefani
Journal:  J Neural Transm (Vienna)       Date:  2008-01-15       Impact factor: 3.575
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  3 in total

1.  Recording Gamma Band Oscillations in Pedunculopontine Nucleus Neurons.

Authors:  Francisco J Urbano; Brennon R Luster; Stasia D'Onofrio; Susan Mahaffey; Edgar Garcia-Rill
Journal:  J Vis Exp       Date:  2016-09-14       Impact factor: 1.355

2.  Modulation of the soleus H reflex by electrical subcortical stimuli in humans.

Authors:  João Costa; Jessica Guzmán; Francesc Valldeoriola; Jordi Rumià; Eduardo Tolosa; Jordi Casanova-Molla; Josep Valls-Solé
Journal:  Exp Brain Res       Date:  2011-06-09       Impact factor: 1.972

Review 3.  Pedunculopontine Nucleus Stimulation: Where are We Now and What Needs to be Done to Move the Field Forward?

Authors:  Hokuto Morita; Chris J Hass; Elena Moro; Atchar Sudhyadhom; Rajeev Kumar; Michael S Okun
Journal:  Front Neurol       Date:  2014-12-04       Impact factor: 4.003
  3 in total

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