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Literature DB >> 18196202

Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients.

Mariangela Pierantozzi¹, Maria Giuseppina Palmieri, Salvatore Galati, Paolo Stanzione, Antonella Peppe, Domenicantonio Tropepi, Livia Brusa, Antonio Pisani, Vincenzo Moschella, Maria Grazia Marciani, Paolo Mazzone, Alessandro Stefani.

Abstract

Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson's disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.

Entities: Chemical Disease Species

Mesh：

Year: 2008 PMID： 18196202 DOI： 10.1007/s00702-007-0001-8

Source DB: PubMed Journal: J Neural Transm (Vienna) ISSN： 0300-9564 Impact factor: 3.575

18 in total

1. Abnormal reciprocal inhibition between antagonist muscles in Parkinson's disease.

Authors: S Meunier; S Pol; J L Houeto; M Vidailhet
Journal: Brain Date: 2000-05 Impact factor: 13.501

2. The role of the pedunculopontine region in basal-ganglia mechanisms of akinesia.

Authors: L E Munro-Davies; J Winter; T Z Aziz; J F Stein
Journal: Exp Brain Res Date: 1999-12 Impact factor: 1.972

Review 3. Parkinsonian rigidity.

Authors: P J Delwaide
Journal: Funct Neurol Date: 2001 Apr-Jun

Review 4. Projections from basal ganglia to tegmentum: a subcortical route for explaining the pathophysiology of Parkinson's disease signs?

Authors: P J Delwaide; J L Pepin; V De Pasqua; A M de Noordhout
Journal: J Neurol Date: 2000-04 Impact factor: 4.849

5. H reflex threshold in Parkinson's disease patients for different stimulus duration.

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Journal: Parkinsonism Relat Disord Date: 2002-12 Impact factor: 4.891

6. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease.

Authors: Alessandro Stefani; Andres M Lozano; Antonella Peppe; Paolo Stanzione; Salvatore Galati; Domenicantonio Tropepi; Mariangela Pierantozzi; Livia Brusa; Eugenio Scarnati; Paolo Mazzone
Journal: Brain Date: 2007-01-24 Impact factor: 13.501

7. H reflex behavior in Parkinson's disease patients and patients with extrapyramidal and pyramidal signs combined.

Authors: M Kushnir; C Klein; J M Rabey
Journal: J Neurol Sci Date: 2001-05-01 Impact factor: 3.181

8. H reflex behavior in Parkinson's disease patients. Effect of stimulus duration.

Authors:
Journal: Parkinsonism Relat Disord Date: 2000-10-01 Impact factor: 4.891

9. Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease.

Authors: Paolo Mazzone; Andres Lozano; Paolo Stanzione; Salvatore Galati; Eugenio Scarnati; Antonella Peppe; Alessandro Stefani
Journal: Neuroreport Date: 2005-11-28 Impact factor: 1.837

10. High-frequency stimulation of the subthalamic nucleus modulates the activity of pedunculopontine neurons through direct activation of excitatory fibres as well as through indirect activation of inhibitory pallidal fibres in the rat.

Authors: Tiziana Florio; Eugenio Scarnati; Giuseppina Confalone; Daniela Minchella; Salvatore Galati; Paolo Stanzione; Alessandro Stefani; Paolo Mazzone
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16 in total

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2. Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease.

Authors: M Karimi; N Golchin; S D Tabbal; T Hershey; T O Videen; J Wu; J W M Usche; F J Revilla; J M Hartlein; A R Wernle; J W Mink; J S Perlmutter
Journal: Brain Date: 2008-08-12 Impact factor: 13.501

3. PPNa-DBS for gait and balance disorders in Parkinson's disease: a double-blind, randomised study.

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Review 4. The deep brain stimulation of the pedunculopontine tegmental nucleus: towards a new stereotactic neurosurgery.

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5. Functional disconnection of the substantia nigra pars compacta from the pedunculopontine nucleus impairs learning of a conditioned avoidance task.

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Review 6. Tracking extranigral degeneration in animal models of Parkinson's disease: quest for effective therapeutic strategies.

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7. Targeting of the pedunculopontine nucleus by an MRI-guided approach: a cadaver study.

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