Literature DB >> 21479719

Simian varicella virus open reading frame 63/70 expression is required for efficient virus replication in culture.

Elizabeth Brazeau1, Mary Wellish, Benedict B Kaufer, B Karsten Tischer, Wayne Gray, Fuchun Zhou, Nikolaus Osterrieder, Teri Hanlon, Anjani Golive, Travis Hall, Sreekala Nair, Gregory P Owens, Niklaus H Mueller, Randall J Cohrs, Subbiah Pugazhenthi, Don Gilden, Ravi Mahalingam.   

Abstract

Simian varicella virus (SVV) open reading frame (ORF) 63, duplicated in the virus genome as ORF 70, is homologous to varicella zoster virus ORF 63/70. Transfection of bacterial artificial chromosome clones containing the wild-type SVV genome and mutants with stop codons in ORF 70, in both ORFs 63 and 70 and the repaired virus DNA sequences into Vero cells produced a cytopathic effect (CPE). The onset of CPE was much slower with the double-mutant transfectants (10 days vs. 3 days) and plaques were smaller. While SVV ORF 63 is not required for replication in culture, its expression leads to robust virus replication.

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Year:  2011        PMID： 21479719      PMCID： PMC3204661          DOI： 10.1007/s13365-011-0025-6

Source DB:  PubMed          Journal:  J Neurovirol        ISSN： 1355-0284            Impact factor:   2.643


  20 in total

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Authors:  P G Kennedy; E Grinfeld; J E Bell
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

2.  Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid.

Authors:  Gregory P Owens; Alanna M Ritchie; Mark P Burgoon; R Anthony Williamson; John R Corboy; Donald H Gilden
Journal:  J Immunol       Date:  2003-09-01       Impact factor: 5.422

3.  Varicella-zoster virus ORF63 inhibits apoptosis of primary human neurons.

Authors:  Chantelle Hood; Anthony L Cunningham; Barry Slobedman; Ann M Arvin; Marvin H Sommer; Paul R Kinchington; Allison Abendroth
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

4.  Cloning the simian varicella virus genome in E. coli as an infectious bacterial artificial chromosome.

Authors:  Wayne L Gray; Fuchun Zhou; Juliane Noffke; B Karsten Tischer
Journal:  Arch Virol       Date:  2011-04-13       Impact factor: 2.574

5.  A cosmid-based system for inserting mutations and foreign genes into the simian varicella virus genome.

Authors:  Wayne L Gray; Ravi Mahalingam
Journal:  J Virol Methods       Date:  2005-07-25       Impact factor: 2.014

6.  Regions of the varicella-zoster virus open reading frame 63 latency-associated protein important for replication in vitro are also critical for efficient establishment of latency.

Authors:  Jeffrey I Cohen; Tammy Krogmann; Sebastien Bontems; Catherine Sadzot-Delvaux; Lesley Pesnicak
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

7.  Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus.

Authors:  M H Sommer; E Zagha; O K Serrano; C C Ku; L Zerboni; A Baiker; R Santos; M Spengler; J Lynch; C Grose; W Ruyechan; J Hay; A M Arvin
Journal:  J Virol       Date:  2001-09       Impact factor: 5.103

8.  Expression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neurons.

Authors:  R Mahalingam; M Wellish; R Cohrs; S Debrus; J Piette; B Rentier; D H Gilden
Journal:  Proc Natl Acad Sci U S A       Date:  1996-03-05       Impact factor: 11.205

9.  The varicella-zoster virus open reading frame 63 latency-associated protein is critical for establishment of latency.

Authors:  Jeffrey I Cohen; Edward Cox; Lesley Pesnicak; Shamala Srinivas; Tammy Krogmann
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

10.  Aberrant intracellular localization of Varicella-Zoster virus regulatory proteins during latency.

Authors:  O Lungu; C A Panagiotidis; P W Annunziato; A A Gershon; S J Silverstein
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-09       Impact factor: 11.205
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  5 in total

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2.  Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques.

Authors:  Ravi Mahalingam; Benedikt B Kaufer; Werner J D Ouwendijk; Georges M G M Verjans; Colin Coleman; Meredith Hunter; Arpita Das; Brent E Palmer; Eric Clambey; Maria A Nagel; Vicki Traina-Dorge
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3.  Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms.

Authors:  Marieke C Verweij; Mary Wellish; Travis Whitmer; Daniel Malouli; Martin Lapel; Stipan Jonjić; Juergen G Haas; Victor R DeFilippis; Ravi Mahalingam; Klaus Früh
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4.  Bacterial artificial chromosome derived simian varicella virus is pathogenic in vivo.

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Journal:  Virol J       Date:  2013-09-08       Impact factor: 4.099

Review 5.  Current In Vivo Models of Varicella-Zoster Virus Neurotropism.

Authors:  Ravi Mahalingam; Anne Gershon; Michael Gershon; Jeffrey I Cohen; Ann Arvin; Leigh Zerboni; Hua Zhu; Wayne Gray; Ilhem Messaoudi; Vicki Traina-Dorge
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  5 in total

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