OBJECTIVES: To assess the effects of trace metals on birth weight and gestational age among newborn babies of mothers without occupational exposure. METHODS: The subjects examined were 142 newborn babies (71 males and 71 females) delivered at two university hospitals in Shanghai, China and their parents. Relationships of newborn birth weight and gestational age to concentrations of arsenic, lead, cadmium, manganese, zinc, and cobalt in maternal and cord blood were investigated. RESULTS: Birth weight was 3379.5 +/- 440.8 (2090-4465) g and the gestational age was 39.7 +/- 1.3 (35-43) weeks. Stepwise regression analysis indicated that, in the male newborn, birth weight and gestational age were inversely related to the logarithm arsenic concentration (4.13 +/- 3.21 microg/l) in mothers' whole blood. CONCLUSION: Arsenic might have a negative influence on newborn birth weight and gestational age at a relatively low exposure level. This effect was observed in male but not female babies, suggesting a sex differential in susceptibility to arsenic at an early stage of development. Although birth weight is believed to be related to gestational age, arsenic may directly affect both birth weight and gestational age.
OBJECTIVES: To assess the effects of trace metals on birth weight and gestational age among newborn babies of mothers without occupational exposure. METHODS: The subjects examined were 142 newborn babies (71 males and 71 females) delivered at two university hospitals in Shanghai, China and their parents. Relationships of newborn birth weight and gestational age to concentrations of arsenic, lead, cadmium, manganese, zinc, and cobalt in maternal and cord blood were investigated. RESULTS: Birth weight was 3379.5 +/- 440.8 (2090-4465) g and the gestational age was 39.7 +/- 1.3 (35-43) weeks. Stepwise regression analysis indicated that, in the male newborn, birth weight and gestational age were inversely related to the logarithm arsenic concentration (4.13 +/- 3.21 microg/l) in mothers' whole blood. CONCLUSION:Arsenic might have a negative influence on newborn birth weight and gestational age at a relatively low exposure level. This effect was observed in male but not female babies, suggesting a sex differential in susceptibility to arsenic at an early stage of development. Although birth weight is believed to be related to gestational age, arsenic may directly affect both birth weight and gestational age.
Authors: Michael S Bloom; Iulia A Neamtiu; Simona Surdu; Cristian Pop; Doru Anastasiu; Allison A Appleton; Edward F Fitzgerald; Eugen S Gurzau Journal: Reprod Toxicol Date: 2015-10-27 Impact factor: 3.143
Authors: Mohammad L Rahman; Linda Valeri; Molly L Kile; Maitreyi Mazumdar; Golam Mostofa; Qazi Qamruzzaman; Mahmudur Rahman; Andrea Baccarelli; Liming Liang; Russ Hauser; David C Christiani Journal: Environ Int Date: 2017-08-05 Impact factor: 9.621
Authors: Anne M Mullin; Chitra Amarasiriwardena; Alejandra Cantoral-Preciado; Birgit Claus Henn; Hsiao-Hsien Leon Hsu; Alison P Sanders; Katherine Svensson; Marcela Tamayo-Ortiz; Martha M Téllez-Rojo; Robert O Wright; Heather H Burris Journal: Environ Res Date: 2019-07-22 Impact factor: 6.498
Authors: Megan E Romano; Daniel A Enquobahrie; Christopher Simpson; Harvey Checkoway; Michelle A Williams Journal: Environ Res Date: 2016-03-11 Impact factor: 6.498
Authors: Anne K Bozack; Andres Cardenas; John Geldhof; Quazi Quamruzzaman; Mahmuder Rahman; Golam Mostofa; David C Christiani; Molly L Kile Journal: Environ Res Date: 2020-01-13 Impact factor: 6.498
Authors: Caitlin G Howe; Shohreh F Farzan; Erika Garcia; Thomas Jursa; Ramsunder Iyer; Kiros Berhane; Thomas A Chavez; Tahlia L Hodes; Brendan H Grubbs; William E Funk; Donald R Smith; Theresa M Bastain; Carrie V Breton Journal: Environ Res Date: 2020-02-27 Impact factor: 6.498