Literature DB >> 21472928

Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile.

Lea Radtke1, Matthieu Willot, Hongyan Sun, Slava Ziegler, Stephanie Sauerland, Carsten Strohmann, Roland Fröhlich, Peter Habenberger, Herbert Waldmann, Mathias Christmann.   

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Year:  2011        PMID： 21472928     DOI： 10.1002/anie.201007790

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  16 in total

1.  Importance of a 4-Alkyl Substituent for Activity in the Englerin Series.

Authors:  Daniel C Elliott; John A Beutler; Kathlyn A Parker
Journal:  ACS Med Chem Lett       Date:  2017-06-06       Impact factor: 4.345

Review 2.  TRPC channels: Structure, function, regulation and recent advances in small molecular probes.

Authors:  Hongbo Wang; Xiaoding Cheng; Jinbin Tian; Yuling Xiao; Tian Tian; Fuchun Xu; Xuechuan Hong; Michael X Zhu
Journal:  Pharmacol Ther       Date:  2020-01-28       Impact factor: 12.310

3.  Synthesis of a stable and orally bioavailable englerin analogue.

Authors:  David M Fash; Cody J Peer; Zhenwu Li; Ian J Talisman; Sima Hayavi; Florian J Sulzmaier; Joe W Ramos; Carole Sourbier; Leonard Neckers; W Douglas Figg; John A Beutler; William J Chain
Journal:  Bioorg Med Chem Lett       Date:  2016-04-08       Impact factor: 2.823

4.  Synthesis and biological analysis of truncated calyculone H.

Authors:  Penagaluri Balasubramanyam; Abimael D Rodríguez
Journal:  Tetrahedron       Date:  2017-01-14       Impact factor: 2.457

5.  Formal synthesis of (-)-englerin A and cytotoxicity studies of truncated englerins.

Authors:  Jing Xu; Eduardo J E Caro-Diaz; Ayse Batova; Steven D E Sullivan; Emmanuel A Theodorakis
Journal:  Chem Asian J       Date:  2012-03-13

Review 6.  Englerins: A Comprehensive Review.

Authors:  Zhenhua Wu; Senzhi Zhao; David M Fash; Zhenwu Li; William J Chain; John A Beutler
Journal:  J Nat Prod       Date:  2017-02-07       Impact factor: 4.050

7.  Identification of an (-)-englerin A analogue, which antagonizes (-)-englerin A at TRPC1/4/5 channels.

Authors:  Hussein N Rubaiy; Tobias Seitz; Sven Hahn; Axel Choidas; Peter Habenberger; Bert Klebl; Klaus Dinkel; Peter Nussbaumer; Herbert Waldmann; Mathias Christmann; David J Beech
Journal:  Br J Pharmacol       Date:  2018-01-25       Impact factor: 8.739

8.  Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery.

Authors:  Daniel J Jansen; Ryan A Shenvi
Journal:  Future Med Chem       Date:  2014-06       Impact factor: 3.808

9.  (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.

Authors:  Yasemin Akbulut; Hannah J Gaunt; Katsuhiko Muraki; Melanie J Ludlow; Mohamed S Amer; Alexander Bruns; Naveen S Vasudev; Lea Radtke; Matthieu Willot; Sven Hahn; Tobias Seitz; Slava Ziegler; Mathias Christmann; David J Beech; Herbert Waldmann
Journal:  Angew Chem Int Ed Engl       Date:  2015-02-23       Impact factor: 15.336

10.  Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition.

Authors:  Zhenhua Wu; Jean-Simon Suppo; Sarka Tumova; Jonathan Strope; Fernando Bravo; Melody Moy; Ethan S Weinstein; Cody J Peer; William D Figg; William J Chain; Antonio M Echavarren; David J Beech; John A Beutler
Journal:  ACS Med Chem Lett       Date:  2020-08-03       Impact factor: 4.345
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